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ONTOLOGY REPORT - ANNOTATIONS


Term:lamellipodium assembly
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Accession:GO:0030032 term browser browse the term
Definition:Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
Synonyms:exact_synonym: lamellipodium biosynthesis;   lamellipodium formation
 related_synonym: lamellipodium biogenesis


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lamellipodium assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ablim1 actin binding LIM protein 1 acts_upstream_of_or_within ISO (PMID:22684256) MGI PMID:22684256 NCBI chrNW_004955431:19,397,136...19,684,574
Ensembl chrNW_004955431:19,402,023...19,683,589
JBrowse link
G Ablim3 actin binding LIM protein family member 3 acts_upstream_of_or_within ISO (PMID:22684256) MGI PMID:22684256 NCBI chrNW_004955415:5,151,445...5,261,300
Ensembl chrNW_004955415:5,153,410...5,261,042
JBrowse link
G Ajuba ajuba LIM protein acts_upstream_of_or_within ISO (MGI:3577694|PMID:15728191) MGI PMID:15728191 MGI:3577694 NCBI chrNW_004955409:37,318,597...37,329,068
Ensembl chrNW_004955409:37,318,597...37,329,155
JBrowse link
G Arhgef4 Rho guanine nucleotide exchange factor 4 involved_in ISO (PMID:17599059) UniProt PMID:17599059 NCBI chrNW_004955459:321,683...534,108 JBrowse link
G Arhgef6 Rac/Cdc42 guanine nucleotide exchange factor 6 involved_in ISO (MGI:5447607|PMID:18325335) UniProt PMID:18325335 MGI:5447607 NCBI chrNW_004955489:8,360,027...8,459,309
Ensembl chrNW_004955489:8,360,072...8,459,377
JBrowse link
G Arhgef7 Rho guanine nucleotide exchange factor 7 involved_in ISO (MGI:5447607|PMID:18325335) UniProt PMID:18325335 MGI:5447607 NCBI chrNW_004955404:1,749,051...1,835,455
Ensembl chrNW_004955404:1,748,665...1,814,575
JBrowse link
G Capzb capping actin protein of muscle Z-line subunit beta acts_upstream_of_or_within ISO (MGI:3051184|PMID:15294161), (MGI:4397629|PMID:19806181) MGI PMID:15294161 PMID:19806181 MGI:3051184 MGI:4397629 NCBI chrNW_004955452:34,454...168,514
Ensembl chrNW_004955452:30,589...169,693
JBrowse link
G Carmil1 capping protein regulator and myosin 1 linker 1 involved_in ISO (PMID:19846667) BHF-UCL PMID:19846667 NCBI chrNW_004955483:1,463,856...1,770,798
Ensembl chrNW_004955483:1,463,805...1,770,520
JBrowse link
G Ccdc88a coiled-coil domain containing 88A involved_in ISO (PMID:16139227) UniProt PMID:16139227 NCBI chrNW_004955424:27,617,833...27,771,385
Ensembl chrNW_004955424:27,617,833...27,771,385
JBrowse link
G Cdh13 cadherin 13 involved_in ISO (PMID:15703273) BHF-UCL PMID:15703273 NCBI chrNW_004955564:407,120...1,549,880
Ensembl chrNW_004955564:408,730...1,426,841
JBrowse link
G Fgd4 FYVE, RhoGEF and PH domain containing 4 acts_upstream_of_or_within ISO (MGI:2179874|PMID:11527409) MGI PMID:11527409 MGI:2179874 NCBI chrNW_004955505:3,108,131...3,314,040
Ensembl chrNW_004955505:3,099,672...3,239,950
JBrowse link
G Golph3 golgi phosphoprotein 3 involved_in ISO (PMID:23500462) UniProt PMID:23500462 NCBI chrNW_004955426:17,980,514...18,017,041
Ensembl chrNW_004955426:17,980,514...18,017,041
JBrowse link
G Itgb1 integrin subunit beta 1 involved_in ISO PMID:20091784 ARUK-UCL PMID:20091784 RGD:6480646 NCBI chrNW_004955462:4,454,809...4,483,227
Ensembl chrNW_004955462:4,454,809...4,484,842
JBrowse link
G Kit KIT proto-oncogene, receptor tyrosine kinase involved_in ISO (MGI:5430902|PMID:10982396) UniProt PMID:10982396 MGI:5430902 NCBI chrNW_004955447:16,149,014...16,226,151
Ensembl chrNW_004955447:16,148,605...16,226,734
JBrowse link
G Nck1 NCK adaptor protein 1 acts_upstream_of_or_within ISO (MGI:2664446|PMID:12808099) MGI PMID:12808099 MGI:2664446 NCBI chrNW_004955501:1,867,956...1,963,091 JBrowse link
G Nck2 NCK adaptor protein 2 acts_upstream_of_or_within ISO (MGI:2664446|PMID:12808099) MGI PMID:12808099 MGI:2664446 NCBI chrNW_004955470:10,487,962...10,593,046
Ensembl chrNW_004955470:10,487,481...10,593,046
JBrowse link
G Nckap1 NCK associated protein 1 acts_upstream_of_or_within ISO (MGI:3033285|PMID:14765121)
(MGI:3701029|PMID:16831833)
MGI PMID:14765121 PMID:16831833 MGI:3033285 MGI:3701029 NCBI chrNW_004955403:14,476,689...14,554,380
Ensembl chrNW_004955403:14,480,162...14,554,702
JBrowse link
G Nup85 nucleoporin 85 acts_upstream_of_or_within ISO (MGI:3588593|PMID:15995708) MGI PMID:15995708 MGI:3588593 NCBI chrNW_004955553:2,079,418...2,107,894
Ensembl chrNW_004955553:2,079,503...2,107,807
JBrowse link
G P2ry12 purinergic receptor P2Y12 involved_in ISO PMID:20091784 ARUK-UCL PMID:20091784 RGD:6480646 NCBI chrNW_004955448:2,442,368...2,488,567
Ensembl chrNW_004955448:2,442,368...2,488,567
JBrowse link
G Parvb parvin beta involved_in ISO (PMID:18325335) UniProt PMID:18325335 NCBI chrNW_004955413:28,962,614...29,020,430
Ensembl chrNW_004955413:28,961,804...29,020,430
JBrowse link
G Pmp22 peripheral myelin protein 22 acts_upstream_of_or_within ISO (MGI:5616959|PMID:25429154) MGI PMID:25429154 MGI:5616959 NCBI chrNW_004955467:2,422,181...2,456,925
Ensembl chrNW_004955467:2,423,659...2,457,307
JBrowse link
G Ptpro protein tyrosine phosphatase receptor type O involved_in ISO (MGI:4941445|PMID:20398064) UniProt PMID:20398064 MGI:4941445 NCBI chrNW_004955413:12,019,026...12,248,026
Ensembl chrNW_004955413:12,018,888...12,248,807
JBrowse link
G Pxn paxillin acts_upstream_of_or_within ISO (MGI:2680875|PMID:14636584) MGI PMID:14636584 MGI:2680875 NCBI chrNW_004955455:11,387,140...11,401,178
Ensembl chrNW_004955455:11,388,378...11,403,082
JBrowse link
G Rac1 Rac family small GTPase 1 involved_in
acts_upstream_of_or_within
ISO (PMID:9312003)
(MGI:3577694|PMID:15728191)
UniProt
MGI
PMID:9312003 PMID:15728191 MGI:3577694 NCBI chrNW_004955460:13,270,159...13,295,562
Ensembl chrNW_004955460:13,270,159...13,311,351
JBrowse link
G Rhod ras homolog family member D involved_in ISO (PMID:23087206) UniProt PMID:23087206 NCBI chrNW_004955422:18,343,611...18,353,269
Ensembl chrNW_004955422:18,342,898...18,353,269
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 involved_in ISO (MGI:3703727|PMID:11726541) UniProt PMID:11726541 MGI:3703727 NCBI chrNW_004955435:5,880,266...5,882,823
Ensembl chrNW_004955435:5,880,288...5,881,436
JBrowse link
G Sh2b1 SH2B adaptor protein 1 acts_upstream_of_or_within ISO (MGI:2176658|PMID:11786545) MGI PMID:11786545 MGI:2176658 NCBI chrNW_004955493:6,583,415...6,592,690
Ensembl chrNW_004955493:6,583,415...6,592,452
JBrowse link
G Spata13 spermatogenesis associated 13 involved_in ISO (PMID:17599059) UniProt PMID:17599059 NCBI chrNW_004955497:4,224,374...4,307,335 JBrowse link
G Spef1 sperm flagellar 1 involved_in ISO (PMID:31473225) UniProt PMID:31473225 NCBI chrNW_004955415:14,620,593...14,626,049
Ensembl chrNW_004955415:14,620,593...14,626,049
JBrowse link
G Vav2 vav guanine nucleotide exchange factor 2 acts_upstream_of_or_within ISO (MGI:3587490|PMID:15728722) MGI PMID:15728722 MGI:3587490 NCBI chrNW_004955513:2,985,246...3,121,324
Ensembl chrNW_004955513:2,985,246...3,121,324
JBrowse link
G Vav3 vav guanine nucleotide exchange factor 3 acts_upstream_of_or_within ISO (MGI:3587490|PMID:15728722) MGI PMID:15728722 MGI:3587490 NCBI chrNW_004955435:11,326,910...11,599,043
Ensembl chrNW_004955435:11,326,910...11,599,043
JBrowse link
G Vcl vinculin acts_upstream_of_or_within ISO (MGI:2447097|PMID:12473693) MGI PMID:12473693 MGI:2447097 NCBI chrNW_004955437:17,812,998...17,920,253
Ensembl chrNW_004955437:17,813,007...17,920,253
JBrowse link
G Wasf2 WASP family member 2 acts_upstream_of_or_within ISO (MGI:2668788|PMID:12879075) MGI PMID:12879075 MGI:2668788 NCBI chrNW_004955452:6,658,854...6,733,964
Ensembl chrNW_004955452:6,658,854...6,680,084
JBrowse link
G Wasf3 WASP family member 3 acts_upstream_of_or_within ISO (MGI:3625634|PMID:16723544) MGI PMID:16723544 MGI:3625634 NCBI chrNW_004955497:6,100,633...6,190,639
Ensembl chrNW_004955497:6,102,909...6,190,770
JBrowse link
G Whamm WASP homolog associated with actin, golgi membranes and microtubules involved_in ISO (PMID:23087206) UniProt PMID:23087206 NCBI chrNW_004955416:13,825,925...13,849,883
Ensembl chrNW_004955416:13,826,372...13,849,245
JBrowse link
lamellipodium assembly involved in ameboidal cell migration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Srgap2 SLIT-ROBO Rho GTPase activating protein 2 involved_in ISO (PMID:20810653) UniProt PMID:20810653 NCBI chrNW_004955406:41,801,235...42,050,731
Ensembl chrNW_004955406:41,801,235...42,050,731
JBrowse link
negative regulation of lamellipodium assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi3 ABI family member 3 involved_in ISO (MGI:6508508|PMID:26428302) ARUK-UCL PMID:26428302 MGI:6508508 NCBI chrNW_004955451:12,241,084...12,248,857 JBrowse link
G Cfl1 cofilin 1 ISO RGD PMID:24093776 RGD:11570550 NCBI chrNW_004955422:19,479,181...19,482,571
Ensembl chrNW_004955422:19,479,181...19,482,571
JBrowse link
G Hrg histidine rich glycoprotein involved_in ISO (PMID:16489009) UniProt PMID:16489009 NCBI chrNW_004955420:21,020,938...21,033,022
Ensembl chrNW_004955420:21,019,212...21,032,976
JBrowse link
G Plxnb3 plexin B3 involved_in ISO PMID:20696765 UniProt PMID:20696765 RGD:8554409 NCBI chrNW_004955580:482,602...495,628
Ensembl chrNW_004955580:484,805...495,445
JBrowse link
G Slit2 slit guidance ligand 2 involved_in ISO (PMID:16439689) UniProt PMID:16439689 NCBI chrNW_004955480:3,982,977...4,314,160
Ensembl chrNW_004955480:3,984,586...4,313,908
JBrowse link
positive regulation of lamellipodium assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi2 abl interactor 2 involved_in ISO (PMID:21107423) ARUK-UCL PMID:21107423 NCBI chrNW_004955457:11,451,851...11,562,692
Ensembl chrNW_004955457:11,451,851...11,562,696
JBrowse link
G Actr2 actin related protein 2 involved_in ISO (PMID:29058690) UniProt PMID:29058690 NCBI chrNW_004955424:19,293,949...19,333,170
Ensembl chrNW_004955424:19,293,949...19,333,170
JBrowse link
G Actr3 actin related protein 3 involved_in ISO (PMID:29058690) RGD
UniProt
PMID:18256280 PMID:29058690 RGD:2306202 NCBI chrNW_004955459:15,216,914...15,284,013
Ensembl chrNW_004955459:15,216,914...15,284,013
JBrowse link
G Akirin1 akirin 1 involved_in ISO (MGI:3850794|PMID:19406121) UniProt PMID:19406121 MGI:3850794 NCBI chrNW_004955452:16,607,980...16,624,376
Ensembl chrNW_004955452:16,607,980...16,624,376
JBrowse link
G Aqp1 aquaporin 1 (Colton blood group) ISO RGD PMID:19539607 RGD:2316079 NCBI chrNW_004955410:32,066,196...32,078,661
Ensembl chrNW_004955410:32,066,196...32,078,717
JBrowse link
G Arpc2 actin related protein 2/3 complex subunit 2 involved_in ISO (PMID:18560548) RGD
UniProt
PMID:15252126 PMID:18560548 RGD:2306210 NCBI chrNW_004955453:15,117,978...15,145,895
Ensembl chrNW_004955453:15,116,093...15,146,041
JBrowse link
G Atp7a ATPase copper transporting alpha ISO RGD PMID:20671235 RGD:11341707 NCBI chrNW_004955557:1,355,471...1,515,725
Ensembl chrNW_004955557:1,355,397...1,515,393
JBrowse link
G Auts2 activator of transcription and developmental regulator AUTS2 involved_in ISO (MGI:5908783|PMID:25533347) UniProt PMID:25533347 MGI:5908783 NCBI chrNW_004955456:10,294,525...11,417,761
Ensembl chrNW_004955456:10,296,377...10,322,455
JBrowse link
G Avil advillin involved_in ISO (PMID:29058690) UniProt PMID:29058690 NCBI chrNW_004955458:5,499,392...5,523,463
Ensembl chrNW_004955458:5,499,652...5,520,137
JBrowse link
G Brk1 BRICK1 subunit of SCAR/WAVE actin nucleating complex involved_in ISO (PMID:21107423)
(PMID:18560548)
ARUK-UCL
UniProt
PMID:18560548 PMID:21107423 NCBI chrNW_004955561:1,545,921...1,554,423
Ensembl chrNW_004955561:1,545,576...1,554,618
JBrowse link
G Carmil2 capping protein regulator and myosin 1 linker 2 involved_in ISO (PMID:26466680) UniProt PMID:26466680 NCBI chrNW_004955484:9,025,409...9,037,942
Ensembl chrNW_004955484:9,025,460...9,037,580
JBrowse link
G Cdc42 cell division cycle 42 involved_in ISO (PMID:8625410) CAFA PMID:8625410 NCBI chrNW_004955452:2,255,940...2,299,042
Ensembl chrNW_004955452:2,255,117...2,299,042
JBrowse link
G Cfl1 cofilin 1 ISO RGD PMID:15252126 RGD:2306210 NCBI chrNW_004955422:19,479,181...19,482,571
Ensembl chrNW_004955422:19,479,181...19,482,571
JBrowse link
G Clrn1 clarin 1 acts_upstream_of_or_within ISO (PMID:19423712) MGI PMID:19423712 NCBI chrNW_004955448:2,062,647...2,106,548
Ensembl chrNW_004955448:2,062,647...2,106,548
JBrowse link
G Dnm2 dynamin 2 ISO RGD PMID:14617821 RGD:9685179 NCBI chrNW_004955495:1,860,644...1,934,589
Ensembl chrNW_004955495:1,860,644...1,934,818
JBrowse link
G Frmd7 FERM domain containing 7 acts_upstream_of_or_within ISO (MGI:5546532|PMID:23967341) MGI PMID:23967341 MGI:5546532 NCBI chrNW_004955473:2,798,736...2,817,770
Ensembl chrNW_004955473:2,774,910...2,817,770
JBrowse link
G Fscn1 fascin actin-bundling protein 1 involved_in ISO (PMID:9571235) UniProt PMID:9571235 NCBI chrNW_004955460:10,402,855...10,412,459
Ensembl chrNW_004955460:10,402,855...10,412,710
JBrowse link
G Hdac4 histone deacetylase 4 ISO RGD PMID:24166750 RGD:9681442 NCBI chrNW_004955542:1,629,691...1,886,160
Ensembl chrNW_004955542:1,629,691...1,886,210
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO RGD PMID:15302889 RGD:2316937 NCBI chrNW_004955538:1,469,544...1,475,010
Ensembl chrNW_004955538:1,469,544...1,475,019
JBrowse link
G Mstn myostatin involved_in ISO (MGI:3850794|PMID:19406121) UniProt PMID:19406121 MGI:3850794 NCBI chrNW_004955403:8,914,505...8,921,190
Ensembl chrNW_004955403:8,914,482...8,923,465
JBrowse link
G Mtor mechanistic target of rapamycin kinase acts_upstream_of_or_within ISO (MGI:3510095|PMID:15467718) MGI PMID:15467718 MGI:3510095 NCBI chrNW_004955486:2,487,642...2,599,694
Ensembl chrNW_004955486:2,487,642...2,599,694
JBrowse link
G Nckap1 NCK associated protein 1 involved_in ISO (PMID:18560548)
(MGI:5897521|PMID:27927633)
(PMID:21107423)
UniProt
BHF-UCL
ARUK-UCL
PMID:18560548 PMID:21107423 PMID:27927633 MGI:5897521 NCBI chrNW_004955403:14,476,689...14,554,380
Ensembl chrNW_004955403:14,480,162...14,554,702
JBrowse link
G Ocln occludin involved_in ISO (PMID:20152177) ARUK-UCL PMID:20152177 NCBI chrNW_004955575:163,646...210,379 JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 involved_in ISO (MGI:6450670|PMID:11038173) BHF-UCL PMID:11038173 MGI:6450670 NCBI chrNW_004955446:1,020,707...1,098,327
Ensembl chrNW_004955446:1,020,043...1,098,820
JBrowse link
G Plce1 phospholipase C epsilon 1 involved_in ISO (PMID:29058690) UniProt PMID:29058690 NCBI chrNW_004955507:555,570...825,568
Ensembl chrNW_004955507:555,499...825,568
JBrowse link
G Rac1 Rac family small GTPase 1 acts_upstream_of_or_within
involved_in
ISO (PMID:15467718)
(PMID:19625648), (PMID:8625410)
RGD
MGI
UniProt
PMID:8625410 PMID:12105187 PMID:15467718 PMID:19625648 RGD:1299247 NCBI chrNW_004955460:13,270,159...13,295,562
Ensembl chrNW_004955460:13,270,159...13,311,351
JBrowse link
G Rac2 Rac family small GTPase 2 involved_in ISO (PMID:19625648)
(MGI:4355276|PMID:19625648)
UniProt PMID:19625648 MGI:4355276 NCBI chrNW_004955413:23,697,504...23,710,668
Ensembl chrNW_004955413:23,693,669...23,710,704
JBrowse link
G Twf2 twinfilin actin binding protein 2 involved_in ISO (PMID:17910947) BHF-UCL PMID:17910947 NCBI chrNW_004955532:3,835,620...3,844,760
Ensembl chrNW_004955532:3,834,579...3,844,760
JBrowse link
G Wasf2 WASP family member 2 involved_in ISO (PMID:18560548), (PMID:21107423) UniProt PMID:18560548 PMID:21107423 NCBI chrNW_004955452:6,658,854...6,733,964
Ensembl chrNW_004955452:6,658,854...6,680,084
JBrowse link
G Wnt1 Wnt family member 1 involved_in ISO (PMID:19756656) BHF-UCL PMID:19756656 NCBI chrNW_004955500:7,797,063...7,811,142
Ensembl chrNW_004955500:7,797,060...7,811,167
JBrowse link
regulation of lamellipodium assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bin3 bridging integrator 3 acts_upstream_of_or_within ISO (MGI:5517720|PMID:23872330) MGI PMID:23872330 MGI:5517720 NCBI chrNW_004955403:46,042,885...46,085,029
Ensembl chrNW_004955403:46,042,885...46,085,029
JBrowse link
G Cdc42 cell division cycle 42 involved_in ISO (PMID:8625410) CAFA PMID:8625410 NCBI chrNW_004955452:2,255,940...2,299,042
Ensembl chrNW_004955452:2,255,117...2,299,042
JBrowse link
G Dmtn dematin actin binding protein involved_in ISO (PMID:10565303) UniProt PMID:10565303 NCBI chrNW_004955403:45,566,180...45,579,062
Ensembl chrNW_004955403:45,566,180...45,578,079
JBrowse link
G Epha2 EPH receptor A2 involved_in ISO (PMID:19573808) UniProt PMID:19573808 NCBI chrNW_004955527:2,120,447...2,151,932
Ensembl chrNW_004955527:2,120,266...2,152,781
JBrowse link
G Fer FER tyrosine kinase involved_in ISO (PMID:19738202) UniProt PMID:19738202 NCBI chrNW_004955418:5,612,919...5,981,549
Ensembl chrNW_004955418:5,614,950...5,981,636
JBrowse link
G Rac1 Rac family small GTPase 1 involved_in ISO (PMID:8625410) CAFA PMID:8625410 NCBI chrNW_004955460:13,270,159...13,295,562
Ensembl chrNW_004955460:13,270,159...13,311,351
JBrowse link
G Was WASP actin nucleation promoting factor involved_in ISO (PMID:8625410) CAFA PMID:8625410 NCBI chrNW_004955543:243,618...253,489
Ensembl chrNW_004955543:247,631...253,274
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12182
    cellular process 11320
      cellular component organization or biogenesis 4934
        cellular component organization 4848
          cell projection organization 1532
            plasma membrane bounded cell projection organization 1515
              lamellipodium organization 91
                lamellipodium assembly 72
                  lamellipodium assembly involved in ameboidal cell migration + 1
                  negative regulation of lamellipodium assembly 5
                  positive regulation of lamellipodium assembly 30
                  regulation of lamellipodium assembly + 39
paths to the root