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ONTOLOGY REPORT - ANNOTATIONS


Term:CCR4-NOT complex
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Accession:GO:0030014 term browser browse the term
Definition:The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8.


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CCR4-NOT complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CNOT1 CCR4-NOT transcription complex subunit 1 ISO (PMID:19558367) UniProtKB PMID:19558367 NCBI chr16:38,793,212...38,902,686
Ensembl chr16:57,919,283...58,027,472
JBrowse link
G CNOT10 CCR4-NOT transcription complex subunit 10 ISO (PMID:19558367), (PMID:23232451) UniProtKB PMID:19558367, PMID:23232451 NCBI chr 3:32,613,213...32,702,062
Ensembl chr 3:32,920,235...33,008,961
JBrowse link
G CNOT11 CCR4-NOT transcription complex subunit 11 ISO (PMID:19558367), (PMID:23232451), (PMID:23303381) UniProtKB PMID:19558367, PMID:23232451, PMID:23303381 Ensembl chr2A:102,228,631...102,245,733 JBrowse link
G CNOT2 CCR4-NOT transcription complex subunit 2 ISO (PMID:19558367) UniProtKB PMID:19558367 NCBI chr12:67,753,703...67,865,375
Ensembl chr12:70,520,722...70,633,149
JBrowse link
G CNOT3 CCR4-NOT transcription complex subunit 3 ISO (PMID:19558367) UniProtKB PMID:19558367 NCBI chr19:51,071,167...51,089,289
Ensembl chr19:59,913,040...59,931,108
JBrowse link
G CNOT4 CCR4-NOT transcription complex subunit 4 colocalizes_with ISO (PMID:19558367) UniProtKB PMID:19558367 NCBI chr 7:127,327,092...127,475,213
Ensembl chr 7:139,828,828...139,905,285
JBrowse link
G CNOT6 CCR4-NOT transcription complex subunit 6 ISO (PMID:19558367) UniProtKB PMID:19558367 NCBI chr 5:175,695,802...175,780,534
Ensembl chr 5:183,007,081...183,089,997
JBrowse link
G CNOT6L CCR4-NOT transcription complex subunit 6 like ISO (PMID:19558367) UniProtKB PMID:19558367 NCBI chr 4:46,374,255...46,482,552
Ensembl chr 4:52,263,010...52,320,307
JBrowse link
G CNOT7 CCR4-NOT transcription complex subunit 7 ISO (PMID:19558367), (PMID:21336257)
(MGI:MGI:73869|PMID:7791755)
UniProtKB
MGI
PMID:7791755, PMID:19558367, PMID:21336257 MGI:MGI:73869 NCBI chr 8:16,439,014...16,459,636
Ensembl chr 8:13,387,288...13,404,445
JBrowse link
G CNOT8 CCR4-NOT transcription complex subunit 8 ISO (PMID:19558367) UniProtKB PMID:19558367 NCBI chr 5:150,262,907...150,280,215
Ensembl chr 5:156,256,448...156,274,293
JBrowse link
G CNOT9 CCR4-NOT transcription complex subunit 9 ISO (PMID:19558367) UniProtKB PMID:19558367 NCBI chr2B:105,826,633...105,854,415
Ensembl chr2B:224,422,467...224,450,133
JBrowse link
G CPEB3 cytoplasmic polyadenylation element binding protein 3 ISO (PMID:21336257) UniProtKB PMID:21336257 NCBI chr10:88,794,186...89,038,808
Ensembl chr10:92,320,240...92,506,089
JBrowse link
G PATL1 PAT1 homolog 1, processing body mRNA decay factor colocalizes_with ISO (PMID:20584987) UniProtKB PMID:20584987 NCBI chr11:54,861,349...54,893,279
Ensembl chr11:58,311,235...58,342,561
JBrowse link
G TNKS1BP1 tankyrase 1 binding protein 1 ISO (PMID:19558367) UniProtKB PMID:19558367 NCBI chr11:52,541,056...52,566,544
Ensembl chr 3:160,029,550...160,054,494
JBrowse link
G TOB1 transducer of ERBB2, 1 ISO (PMID:21336257) UniProtKB PMID:21336257 NCBI chr17:44,953,343...44,957,465
Ensembl chr17:49,825,646...49,826,683
JBrowse link
G ZFP36 ZFP36 ring finger protein colocalizes_with ISO (MGI:MGI:5795819|PMID:20595389) UniProtKB PMID:20595389 MGI:MGI:5795819 NCBI chr19:36,505,056...36,507,693
Ensembl chr19:45,052,801...45,055,390
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 12626
    protein-containing complex 3923
      CCR4-NOT complex 16
        CCR4-NOT core complex 0
Path 2
Term Annotations click to browse term
  cellular_component 12626
    cellular anatomical entity 12523
      intracellular anatomical structure 10677
        CCR4-NOT complex 16
          CCR4-NOT core complex 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.