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ONTOLOGY REPORT - ANNOTATIONS


Term:CCR4-NOT complex
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Accession:GO:0030014 term browser browse the term
Definition:The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8.


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CCR4-NOT complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnot1 CCR4-NOT transcription complex, subunit 1 ISO (PMID:19558367) RGD PMID:19558367 NCBI chr19:9,668,186...9,761,605
Ensembl chr19:9,668,186...9,761,605
JBrowse link
G Cnot10 CCR4-NOT transcription complex, subunit 10 ISS
IEA
IBA
ISO
GO_REF:0000024
GO_REF:0000104
PMID:21873635
(PMID:19558367), (PMID:23232451)
UniProt
RGD
PMID:19558367, PMID:23232451, PMID:21873635 GO_REF:0000024, GO_REF:0000104, RGD:13792537 NCBI chr 8:122,634,681...122,696,466
Ensembl chr 8:122,634,685...122,679,720
JBrowse link
G Cnot11 CCR4-NOT transcription complex, subunit 11 ISS
ISO
GO_REF:0000024
(PMID:19558367), (PMID:23232451), (PMID:23303381)
UniProt
RGD
PMID:19558367, PMID:23232451, PMID:23303381 GO_REF:0000024 NCBI chr 9:46,270,229...46,279,928
Ensembl chr 9:46,270,122...46,279,995
JBrowse link
G Cnot2 CCR4-NOT transcription complex, subunit 2 ISO (PMID:19558367) RGD PMID:19558367 NCBI chr 7:59,526,105...59,617,307
Ensembl chr 7:59,527,124...59,587,385
JBrowse link
G Cnot3 CCR4-NOT transcription complex, subunit 3 ISO (PMID:19558367) RGD PMID:19558367 NCBI chr 1:64,130,823...64,147,066
Ensembl chr 1:64,130,908...64,147,251
JBrowse link
G Cnot4 CCR4-NOT transcription complex, subunit 4 colocalizes_with ISO
IBA
(PMID:19558367)
PMID:21873635
RGD PMID:19558367, PMID:21873635 RGD:13792537 NCBI chr 4:62,561,443...62,663,225
Ensembl chr 4:62,561,444...62,663,200
JBrowse link
G Cnot6 CCR4-NOT transcription complex, subunit 6 ISO
IEA
IBA
ISS
(PMID:19558367)
GO_REF:0000107
PMID:21873635
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:19558367, PMID:21873635 GO_REF:0000024, GO_REF:0000107, RGD:13792537 NCBI chr10:35,144,291...35,195,126
Ensembl chr10:35,146,337...35,187,416
JBrowse link
G Cnot6l CCR4-NOT transcription complex, subunit 6-like ISO
IBA
(PMID:19558367)
PMID:21873635
RGD PMID:19558367, PMID:21873635 RGD:13792537 NCBI chr14:15,059,101...15,148,255
Ensembl chr14:15,059,387...15,146,586
JBrowse link
G Cnot7 CCR4-NOT transcription complex, subunit 7 ISO UniProtKB:P31384 (MGI:MGI:73869|PMID:7791755)
(PMID:19558367), (PMID:21336257)
RGD PMID:7791755, PMID:19558367, PMID:21336257 MGI:MGI:73869 NCBI chr16:54,899,452...54,918,616
Ensembl chr16:54,899,452...54,918,613
JBrowse link
G Cnot8 CCR4-NOT transcription complex, subunit 8 ISO (PMID:19558367) RGD PMID:19558367 NCBI chr10:43,538,150...43,551,271
Ensembl chr10:43,538,160...43,551,271
JBrowse link
G Cnot9 CCR4-NOT transcription complex subunit 9 ISO
ISS
(PMID:19558367)
GO_REF:0000024
RGD
UniProt
PMID:19558367 GO_REF:0000024 NCBI chr 9:81,783,349...81,808,815
Ensembl chr 9:81,783,349...81,808,805
JBrowse link
G Cpeb3 cytoplasmic polyadenylation element binding protein 3 ISO (PMID:21336257) RGD PMID:21336257 NCBI chr 1:255,660,165...255,842,671
Ensembl chr 1:255,665,238...255,815,733
JBrowse link
G Patl1 PAT1 homolog 1, processing body mRNA decay factor colocalizes_with ISO
ISS
(PMID:20584987)
GO_REF:0000024
RGD
UniProt
PMID:20584987 GO_REF:0000024 NCBI chr 1:228,337,756...228,369,719
Ensembl chr 1:228,337,767...228,369,761
JBrowse link
G Tnks1bp1 tankyrase 1 binding protein 1 ISO (PMID:19558367) RGD PMID:19558367 NCBI chr 3:72,458,520...72,483,206
Ensembl chr 3:72,460,889...72,483,217
JBrowse link
G Tob1 transducer of ErbB-2.1 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:21336257)
Ensembl
UniProt
RGD
PMID:21336257 GO_REF:0000024, GO_REF:0000107 NCBI chr10:81,913,689...81,915,727
Ensembl chr10:81,913,689...81,915,716
JBrowse link
G Zfp36 zinc finger protein 36 colocalizes_with IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:5795819|PMID:20595389)
Ensembl
UniProt
RGD
PMID:20595389 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5795819 NCBI chr 1:85,380,088...85,382,565
Ensembl chr 1:85,380,088...85,382,569
JBrowse link
CCR4-NOT core complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnot1 CCR4-NOT transcription complex, subunit 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:9,668,186...9,761,605
Ensembl chr19:9,668,186...9,761,605
JBrowse link
G Cnot2 CCR4-NOT transcription complex, subunit 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:59,526,105...59,617,307
Ensembl chr 7:59,527,124...59,587,385
JBrowse link
G Cnot3 CCR4-NOT transcription complex, subunit 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:64,130,823...64,147,066
Ensembl chr 1:64,130,908...64,147,251
JBrowse link
G Cnot7 CCR4-NOT transcription complex, subunit 7 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:54,899,452...54,918,616
Ensembl chr16:54,899,452...54,918,613
JBrowse link
G Cnot8 CCR4-NOT transcription complex, subunit 8 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:43,538,150...43,551,271
Ensembl chr10:43,538,160...43,551,271
JBrowse link
G Cnot9 CCR4-NOT transcription complex subunit 9 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:81,783,349...81,808,815
Ensembl chr 9:81,783,349...81,808,805
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20609
    protein-containing complex 6093
      CCR4-NOT complex 16
        CCR4-NOT core complex 6
Path 2
Term Annotations click to browse term
  cellular_component 20609
    cellular anatomical entity 20358
      intracellular anatomical structure 14706
        CCR4-NOT complex 16
          CCR4-NOT core complex 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.