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ONTOLOGY REPORT - ANNOTATIONS

Term:adaptation of signaling pathway
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Accession:GO:0023058 term browser browse the term
Definition:The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.
Synonyms:exact_synonym: adaptation of signalling pathway

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desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936677:3,173,054...3,181,475
Ensembl chrNW_004936677:3,172,925...3,181,520 		JBrowse link
G Gipr gastric inhibitory polypeptide receptor ISO RGD PMID:8928774 RGD:2312614 NCBI chrNW_004936706:2,052,069...2,062,722
Ensembl chrNW_004936706:2,053,433...2,061,241 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 involved_in
acts_upstream_of_or_within		 ISO
IEA		 RGD
Ensembl
TreeGrafter		 PMID:17908240 PMID:30075183 GO_REF:0000107 GO_REF:0000118 RGD:13792694 RGD:7242040 NCBI chrNW_004936599:2,437,061...2,456,141
Ensembl chrNW_004936599:2,437,032...2,456,147 		JBrowse link
G Grk3 G protein-coupled receptor kinase 3 involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:8381966 PMID:20837135 GO_REF:0000118 RGD:5685022 RGD:5685621 NCBI chrNW_004936657:425,902...522,331
Ensembl chrNW_004936657:426,787...521,198 		JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO RGD PMID:8626574 PMID:30075183 RGD:13792694 RGD:61618 NCBI chrNW_004936486:8,720,036...8,830,472
Ensembl chrNW_004936486:8,720,036...8,831,075 		JBrowse link
G Grk6 G protein-coupled receptor kinase 6 ISO RGD PMID:12810562 PMID:17908240 RGD:1299124 RGD:7242040 NCBI chrNW_004936597:1,706,671...1,722,370
Ensembl chrNW_004936597:1,706,665...1,722,370 		JBrowse link
G Grm5 glutamate metabotropic receptor 5 involved_in ISO PMID:12514208 UniProt PMID:12514208 RGD:728711 NCBI chrNW_004936736:623,118...1,060,273
Ensembl chrNW_004936736:623,013...1,064,054 		JBrowse link
G LOC101977693 lymphocyte antigen 6G6e-like involved_in
acts_upstream_of_or_within		 IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936727:1,819,792...1,821,533 JBrowse link
G Ptger3 prostaglandin E receptor 3 ISO RGD PMID:9350980 RGD:9850278 NCBI chrNW_004936591:1,174,364...1,250,233
Ensembl chrNW_004936591:1,174,069...1,249,410 		JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936528:8,005,223...8,007,586
Ensembl chrNW_004936528:8,005,189...8,007,643 		JBrowse link
G Arr3 arrestin 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936762:1,194,251...1,207,914
Ensembl chrNW_004936762:1,194,166...1,208,844 		JBrowse link
G Arrb1 arrestin beta 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936498:4,089,621...4,172,749
Ensembl chrNW_004936498:4,094,893...4,172,755 		JBrowse link
G Arrb2 arrestin beta 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936677:3,173,054...3,181,475
Ensembl chrNW_004936677:3,172,925...3,181,520 		JBrowse link
G Calca calcitonin related polypeptide alpha involved_in ISO (PMID:10882736) UniProt PMID:10882736 NCBI chrNW_004936528:3,800,801...3,806,000
Ensembl chrNW_004936528:3,800,577...3,805,004 		JBrowse link
G Dnm1 dynamin 1 ISO RGD PMID:14709338 RGD:9685157 NCBI chrNW_004936487:15,767,897...15,797,722
Ensembl chrNW_004936487:15,767,897...15,801,211 		JBrowse link
G Dnm2 dynamin 2 ISO RGD PMID:14709338 RGD:9685157 NCBI chrNW_004936659:957,408...1,046,393
Ensembl chrNW_004936659:957,392...1,049,188 		JBrowse link
G Drd2 dopamine receptor D2 ISO RGD PMID:14617818 RGD:1581465 NCBI chrNW_004936612:1,094,686...1,154,149
Ensembl chrNW_004936612:1,094,680...1,154,798 		JBrowse link
G Drd3 dopamine receptor D3 involved_in ISO
IEA		 RGD
Ensembl		 PMID:14617818 GO_REF:0000107 RGD:1581465 NCBI chrNW_004936536:1,580,732...1,616,726
Ensembl chrNW_004936536:1,580,732...1,616,725 		JBrowse link
G LOC101957203 general transcription factor IIH subunit 2 involved_in ISO (PMID:15775968) UniProt PMID:15775968 NCBI chrNW_004936480:72,730...92,868 JBrowse link
G Pld2 phospholipase D2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936677:2,870,664...2,883,545
Ensembl chrNW_004936677:2,870,660...2,883,567 		JBrowse link
G Sag S-antigen visual arrestin involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936525:3,932,118...3,965,651
Ensembl chrNW_004936525:3,931,933...3,964,834 		JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2b calcium/calmodulin dependent protein kinase II beta acts_upstream_of_or_within ISO (PMID:19332541) MGI PMID:19332541 NCBI chrNW_004936478:19,183,493...19,278,457
Ensembl chrNW_004936478:19,180,726...19,278,920 		JBrowse link
negative adaptation of signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Entrep1 endosomal transmembrane epsin interactor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936503:5,611,867...5,671,947
Ensembl chrNW_004936503:5,610,573...5,672,308 		JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Necab2 N-terminal EF-hand calcium binding protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936641:3,779,024...3,802,883
Ensembl chrNW_004936641:3,779,374...3,799,581 		JBrowse link
G Ubqln2 ubiquilin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936819:530,833...534,185
Ensembl chrNW_004936819:532,037...533,920 		JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apela apelin receptor early endogenous ligand involved_in ISO (PMID:25639753) UniProt PMID:25639753 NCBI chrNW_004936555:969,902...978,736 JBrowse link
G Apln apelin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936479:1,889,930...1,899,811
Ensembl chrNW_004936479:1,890,229...1,899,730 		JBrowse link
G Aplnr apelin receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936581:5,230,836...5,234,562
Ensembl chrNW_004936581:5,231,242...5,232,384 		JBrowse link
G App amyloid beta precursor protein involved_in ISO (PMID:18723082) ARUK-UCL PMID:18723082 NCBI chrNW_004936640:1,549,977...1,787,436
Ensembl chrNW_004936640:1,550,167...1,787,286 		JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chrNW_004936591:1,174,364...1,250,233
Ensembl chrNW_004936591:1,174,069...1,249,410 		JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chrNW_004936591:1,174,364...1,250,233
Ensembl chrNW_004936591:1,174,069...1,249,410 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17417
    cellular process 17021
      signal transduction 5740
        regulation of signal transduction 2993
          adaptation of signaling pathway 28
            adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion + 0
            negative adaptation of signaling pathway + 28
            positive adaptation of signaling pathway 0
Path 2
Term Annotations click to browse term
  biological_process 17417
    biological regulation 11394
      regulation of biological process 11029
        signaling 6234
          regulation of signaling 3480
            regulation of signal transduction 2993
              adaptation of signaling pathway 28
                adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion + 0
                negative adaptation of signaling pathway + 28
                positive adaptation of signaling pathway 0
paths to the root