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ONTOLOGY REPORT - ANNOTATIONS

Term:adaptation of signaling pathway
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Accession:GO:0023058 term browser browse the term
Definition:The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.
Synonyms:exact_synonym: adaptation of signalling pathway


show annotations for term's descendants           Sort by:
desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARRB2 arrestin beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:52,161,776...52,170,362
Ensembl chr12:52,161,778...52,170,342 		JBrowse link
G GIPR gastric inhibitory polypeptide receptor ISO RGD PMID:8928774 RGD:2312614 NCBI chr 6:52,022,667...52,033,959
Ensembl chr 6:52,022,681...52,033,954 		JBrowse link
G GRK2 G protein-coupled receptor kinase 2 involved_in
acts_upstream_of_or_within		 ISO
IEA
IBA		 RGD
Ensembl
GO_Central		 PMID:17908240 PMID:30075183 GO_REF:0000033 GO_REF:0000107 RGD:13792694 RGD:7242040 NCBI chr 2:5,209,435...5,227,543
Ensembl chr 2:5,209,439...5,227,758 		JBrowse link
G GRK3 G protein-coupled receptor kinase 3 involved_in ISO
IBA		 RGD
GO_Central		 PMID:8381966 PMID:20837135 GO_REF:0000033 RGD:5685022 RGD:5685621 NCBI chr14:43,305,255...43,445,626
Ensembl chr14:43,224,930...43,442,965 		JBrowse link
G GRK4 G protein-coupled receptor kinase 4 ISO RGD PMID:15166006 RGD:1598508 NCBI chr 8:1,737,960...1,792,390
Ensembl chr 8:1,738,333...1,792,374 		JBrowse link
G GRK5 G protein-coupled receptor kinase 5 ISO RGD PMID:8626574 PMID:30075183 RGD:13792694 RGD:61618 NCBI chr14:129,113,933...129,351,135
Ensembl chr14:129,113,603...129,347,152 		JBrowse link
G GRK6 G protein-coupled receptor kinase 6 ISO RGD PMID:12810562 PMID:17908240 RGD:1299124 RGD:7242040 NCBI chr 2:80,496,105...80,527,208
Ensembl chr 2:80,508,979...80,527,210 		JBrowse link
G GRM5 glutamate metabotropic receptor 5 involved_in ISO PMID:12514208 UniProt PMID:12514208 RGD:728711 NCBI chr 9:21,914,422...22,438,200
Ensembl chr 9:21,917,735...22,436,063 		JBrowse link
G LOC110261493 sperm acrosome membrane-associated protein 4-like involved_in
acts_upstream_of_or_within		 IBA
IEA		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:23,823,392...23,825,431 JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:9350980 RGD:9850278 NCBI chr 6:141,958,955...142,160,437
Ensembl chr 6:141,958,955...142,161,286 		JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADM adrenomedullin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:49,229,223...49,231,521
Ensembl chr 2:49,229,223...49,231,866 		JBrowse link
G ARRB1 arrestin beta 1 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:9,516,944...9,597,446
Ensembl chr 9:9,516,947...9,597,976 		JBrowse link
G ARRB2 arrestin beta 2 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr12:52,161,776...52,170,362
Ensembl chr12:52,161,778...52,170,342 		JBrowse link
G CALCB calcitonin-related polypeptide beta involved_in ISO (PMID:10882736) UniProt PMID:10882736 NCBI chr 2:44,043,135...44,048,651 JBrowse link
G DNM1 dynamin 1 ISO RGD PMID:14709338 RGD:9685157 NCBI chr 1:268,653,045...268,702,233
Ensembl chr 1:268,653,070...268,702,222 		JBrowse link
G DNM2 dynamin 2 ISO RGD PMID:14709338 RGD:9685157 NCBI chr 2:69,474,011...69,574,427
Ensembl chr 2:69,474,031...69,574,424 		JBrowse link
G DRD2 dopamine receptor D2 ISO RGD PMID:14617818 RGD:1581465 NCBI chr 9:41,068,618...41,135,262
Ensembl chr 9:41,068,779...41,133,599 		JBrowse link
G DRD3 dopamine receptor D3 involved_in ISO
IEA		 RGD
Ensembl		 PMID:14617818 GO_REF:0000107 RGD:1581465 NCBI chr13:145,769,294...145,817,997
Ensembl chr13:145,771,774...145,819,168 		JBrowse link
G GRK4 G protein-coupled receptor kinase 4 ISO RGD PMID:12519791 RGD:1304268 NCBI chr 8:1,737,960...1,792,390
Ensembl chr 8:1,738,333...1,792,374 		JBrowse link
G GTF2H2 general transcription factor IIH subunit 2 involved_in ISO (PMID:15775968) UniProt PMID:15775968 NCBI chr16:47,658,015...47,700,926 JBrowse link
G PLD2 phospholipase D2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr12:52,073,913...52,087,804
Ensembl chr12:52,073,914...52,087,809 		JBrowse link
G SAG S-antigen visual arrestin involved_in IBA GO_Central GO_REF:0000033 NCBI chr15:133,704,975...133,741,844
Ensembl chr15:133,705,008...133,741,798 		JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAMK2B calcium/calmodulin dependent protein kinase II beta acts_upstream_of_or_within ISO (PMID:19332541) MGI PMID:19332541 NCBI chr18:50,862,225...50,956,263
Ensembl chr18:50,861,466...50,956,225 		JBrowse link
negative adaptation of signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENTREP1 endosomal transmembrane epsin interactor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:222,658,488...222,725,262
Ensembl chr 1:222,658,382...222,725,259 		JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NECAB2 N-terminal EF-hand calcium binding protein 2 involved_in ISO (PMID:17689978) UniProt PMID:17689978 NCBI chr 6:4,598,752...4,641,450 JBrowse link
G UBQLN2 ubiquilin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:48,948,062...48,951,392
Ensembl chr  X:48,948,389...48,950,263 		JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APELA apelin receptor early endogenous ligand involved_in ISO (PMID:25639753) UniProt PMID:25639753 NCBI chr 8:53,703,735...53,736,989 JBrowse link
G APLN apelin involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:106,236,746...106,246,563
Ensembl chr  X:106,236,749...106,246,377 		JBrowse link
G APLNR apelin receptor involved_in IEA Ensembl GO_REF:0000107
G APP amyloid beta precursor protein involved_in ISO (PMID:18723082) ARUK-UCL PMID:18723082 NCBI chr13:189,434,854...189,716,120
Ensembl chr13:189,435,094...189,716,056 		JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chr 6:141,958,955...142,160,437
Ensembl chr 6:141,958,955...142,161,286 		JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chr 6:141,958,955...142,160,437
Ensembl chr 6:141,958,955...142,161,286 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18944
    cellular process 18487
      signal transduction 7020
        regulation of signal transduction 3191
          adaptation of signaling pathway 28
            adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion + 0
            negative adaptation of signaling pathway + 28
            positive adaptation of signaling pathway 0
Path 2
Term Annotations click to browse term
  biological_process 18944
    biological regulation 13003
      regulation of biological process 12621
        signaling 7561
          regulation of signaling 3730
            regulation of signal transduction 3191
              adaptation of signaling pathway 28
                adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion + 0
                negative adaptation of signaling pathway + 28
                positive adaptation of signaling pathway 0
paths to the root