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ONTOLOGY REPORT - ANNOTATIONS

Term:adaptation of signaling pathway
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Accession:GO:0023058 term browser browse the term
Definition:The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.
Synonyms:exact_synonym: adaptation of signalling pathway

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desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin beta 2 involved_in ISO (PMID:12582207) UniProt PMID:12582207 NCBI chrNW_004624786:8,568,102...8,576,445
Ensembl chrNW_004624786:8,568,198...8,577,914 		JBrowse link
G Gipr gastric inhibitory polypeptide receptor ISO RGD PMID:8928774 RGD:2312614 NCBI chrNW_004624832:7,497,147...7,507,123
Ensembl chrNW_004624832:7,497,258...7,507,212 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:7761854)
(PMID:10338466)		 MGI
TreeGrafter
RGD		 PMID:7761854 PMID:10338466 PMID:17908240 PMID:30075183 GO_REF:0000118 RGD:13792694 RGD:7242040 NCBI chrNW_004624767:19,212,218...19,231,218
Ensembl chrNW_004624767:19,210,965...19,231,082 		JBrowse link
G Grk3 G protein-coupled receptor kinase 3 involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:8381966 PMID:20837135 GO_REF:0000118 RGD:5685022 RGD:5685621 NCBI chrNW_004624747:1,567,540...1,758,251
Ensembl chrNW_004624747:1,576,681...1,758,201 		JBrowse link
G Grk4 G protein-coupled receptor kinase 4 ISO RGD PMID:15166006 RGD:1598508 NCBI chrNW_004624755:24,741,985...24,789,972
Ensembl chrNW_004624755:24,742,073...24,830,314 		JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO RGD PMID:8626574 PMID:30075183 RGD:13792694 RGD:61618 NCBI chrNW_004624737:27,379,114...27,600,132
Ensembl chrNW_004624737:27,375,149...27,600,210 		JBrowse link
G Grk6 G protein-coupled receptor kinase 6 ISO RGD PMID:12810562 PMID:17908240 RGD:1299124 RGD:7242040 NCBI chrNW_004624733:12,633,565...12,661,284 JBrowse link
G Grm5 glutamate metabotropic receptor 5 involved_in ISO PMID:12514208 UniProt PMID:12514208 RGD:728711 NCBI chrNW_004624845:1,064,866...1,631,722
Ensembl chrNW_004624845:1,079,564...1,627,880 		JBrowse link
G LOC101706118 sperm acrosome membrane-associated protein 4-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624754:24,497,812...24,499,426 JBrowse link
G Ptger3 prostaglandin E receptor 3 ISO RGD PMID:9350980 RGD:9850278 NCBI chrNW_004624742:25,177,340...25,356,911 JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624766:2,402,152...2,404,343
Ensembl chrNW_004624766:2,401,769...2,404,446 		JBrowse link
G Arr3 arrestin 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624903:246,888...255,169 JBrowse link
G Arrb1 arrestin beta 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624817:1,750,448...1,828,399
Ensembl chrNW_004624817:1,750,156...1,823,309 		JBrowse link
G Arrb2 arrestin beta 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624786:8,568,102...8,576,445
Ensembl chrNW_004624786:8,568,198...8,577,914 		JBrowse link
G Calca calcitonin related polypeptide alpha involved_in ISO (PMID:10882736) UniProt PMID:10882736 NCBI chrNW_004624766:6,764,388...6,771,396
Ensembl chrNW_004624766:6,766,185...6,768,173 		JBrowse link
G Dnm1 dynamin 1 ISO RGD PMID:14709338 RGD:9685157 NCBI chrNW_004624760:6,605,902...6,646,575
Ensembl chrNW_004624760:6,604,787...6,646,622 		JBrowse link
G Dnm2 dynamin 2 ISO RGD PMID:14709338 RGD:9685157 NCBI chrNW_004624828:2,727,136...2,805,248
Ensembl chrNW_004624828:2,727,112...2,807,319 		JBrowse link
G Drd2 dopamine receptor D2 ISO RGD PMID:14617818 RGD:1581465 NCBI chrNW_004624784:8,828,589...8,906,617
Ensembl chrNW_004624784:8,827,006...8,865,529 		JBrowse link
G Drd3 dopamine receptor D3 involved_in ISO (PMID:18424554) RGD
BHF-UCL		 PMID:14617818 PMID:18424554 RGD:1581465 NCBI chrNW_004624731:34,318,733...34,369,111
Ensembl chrNW_004624731:34,319,130...34,363,184 		JBrowse link
G Grk4 G protein-coupled receptor kinase 4 ISO RGD PMID:12519791 RGD:1304268 NCBI chrNW_004624755:24,741,985...24,789,972
Ensembl chrNW_004624755:24,742,073...24,830,314 		JBrowse link
G Gtf2h2 general transcription factor IIH subunit 2 involved_in ISO (PMID:15775968) UniProt PMID:15775968 NCBI chrNW_004624905:395,922...421,203 JBrowse link
G Pld2 phospholipase D2 acts_upstream_of_or_within ISO (PMID:14718562) MGI PMID:14718562 NCBI chrNW_004624786:8,690,968...8,702,213
Ensembl chrNW_004624786:8,690,461...8,702,771 		JBrowse link
G Sag S-antigen visual arrestin involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624843:5,837,105...5,870,417
Ensembl chrNW_004624843:5,844,823...5,870,300 		JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2b calcium/calmodulin dependent protein kinase II beta acts_upstream_of_or_within ISO (PMID:19332541) MGI PMID:19332541 NCBI chrNW_004624740:7,750,327...7,828,891
Ensembl chrNW_004624740:7,750,245...7,831,454 		JBrowse link
negative adaptation of signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Entrep1 endosomal transmembrane epsin interactor 1 involved_in ISO (PMID:34927784) UniProt PMID:34927784 NCBI chrNW_004624736:3,668,349...3,748,010
Ensembl chrNW_004624736:3,668,989...3,747,463 		JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Necab2 N-terminal EF-hand calcium binding protein 2 involved_in ISO (PMID:17689978) UniProt PMID:17689978 NCBI chrNW_004624746:3,552,719...3,574,124
Ensembl chrNW_004624746:3,552,719...3,577,433 		JBrowse link
G Ubqln2 ubiquilin 2 involved_in ISO (PMID:18199683) UniProt PMID:18199683 NCBI chrNW_004624910:1,547,942...1,551,323
Ensembl chrNW_004624910:1,548,249...1,550,126 		JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apela apelin receptor early endogenous ligand involved_in ISO (PMID:25639753) UniProt PMID:25639753 NCBI chrNW_004624758:11,944,563...11,954,027 JBrowse link
G Apln apelin involved_in ISO (PMID:11359874) UniProt PMID:11359874 RGD:12907555 NCBI chrNW_004624797:8,857,490...8,866,157
Ensembl chrNW_004624797:8,857,070...8,866,329 		JBrowse link
G Aplnr apelin receptor involved_in ISO (PMID:25639753) UniProt PMID:25639753 NCBI chrNW_004624864:3,308,548...3,311,431
Ensembl chrNW_004624864:3,308,794...3,309,939 		JBrowse link
G App amyloid beta precursor protein involved_in ISO (PMID:18723082) ARUK-UCL PMID:18723082 NCBI chrNW_004624745:13,904,912...14,159,374
Ensembl chrNW_004624745:13,902,577...14,159,372 		JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chrNW_004624742:25,177,340...25,356,911 JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chrNW_004624742:25,177,340...25,356,911 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17650
    cellular process 17226
      signal transduction 6122
        regulation of signal transduction 2973
          adaptation of signaling pathway 29
            adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion + 0
            negative adaptation of signaling pathway + 29
            positive adaptation of signaling pathway 0
Path 2
Term Annotations click to browse term
  biological_process 17650
    biological regulation 11838
      regulation of biological process 11481
        signaling 6618
          regulation of signaling 3457
            regulation of signal transduction 2973
              adaptation of signaling pathway 29
                adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion + 0
                negative adaptation of signaling pathway + 29
                positive adaptation of signaling pathway 0
paths to the root