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ONTOLOGY REPORT - ANNOTATIONS

Term:adaptation of signaling pathway
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Accession:GO:0023058 term browser browse the term
Definition:The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.
Synonyms:exact_synonym: adaptation of signalling pathway


show annotations for term's descendants           Sort by:
desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin, beta 2 involved_in ISO GO_Central GO_REF:0000119 NCBI chr11:70,323,051...70,331,654
Ensembl chr11:70,323,461...70,331,654 		JBrowse link
G Gipr gastric inhibitory polypeptide receptor involved_in ISO
IEA		 RGD
GO_Central
Ensembl		 PMID:8928774 GO_REF:0000096 GO_REF:0000107 RGD:2312614 NCBI chr 7:18,889,988...18,904,173
Ensembl chr 7:18,889,986...18,900,052 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 acts_upstream_of_or_within
involved_in		 ISO
IMP
IGI
IBA		 (PMID:10338466)
(PMID:7761854)		 RGD
MGI
GO_Central		 PMID:7761854 PMID:10338466 PMID:17908240 PMID:30075183 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 RGD:13792694 RGD:7242040 NCBI chr19:4,336,029...4,356,356
Ensembl chr19:4,336,029...4,356,250 		JBrowse link
G Grk3 G protein-coupled receptor kinase 3 involved_in ISO
IBA		 RGD
GO_Central		 PMID:8381966 PMID:20837135 GO_REF:0000033 GO_REF:0000096 RGD:5685022 RGD:5685621 NCBI chr 5:113,058,344...113,163,518
Ensembl chr 5:113,058,348...113,163,657 		JBrowse link
G Grk4 G protein-coupled receptor kinase 4 involved_in ISO RGD
GO_Central		 PMID:15166006 GO_REF:0000096 RGD:1598508 NCBI chr 5:34,817,641...34,912,649
Ensembl chr 5:34,817,723...34,912,649 		JBrowse link
G Grk5 G protein-coupled receptor kinase 5 involved_in ISO RGD
GO_Central		 PMID:8626574 PMID:30075183 GO_REF:0000096 RGD:13792694 RGD:61618 NCBI chr19:60,877,995...61,084,406
Ensembl chr19:60,878,187...61,084,406 		JBrowse link
G Grk6 G protein-coupled receptor kinase 6 involved_in ISO RGD
GO_Central		 PMID:12810562 PMID:17908240 GO_REF:0000096 RGD:1299124 RGD:7242040 NCBI chr13:55,592,865...55,608,740
Ensembl chr13:55,592,885...55,608,740 		JBrowse link
G Grm5 glutamate receptor, metabotropic 5 involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000096 GO_REF:0000107 NCBI chr 7:87,233,212...87,784,271
Ensembl chr 7:87,233,376...87,784,115 		JBrowse link
G Ly6g6e lymphocyte antigen 6 family member G6E acts_upstream_of_or_within
involved_in		 IDA
IBA		 (PMID:26276394) MGI
GO_Central		 PMID:26276394 GO_REF:0000033 NCBI chr17:35,295,843...35,297,781
Ensembl chr17:35,295,878...35,297,780 		JBrowse link
G Ptger3 prostaglandin E receptor 3 (subtype EP3) involved_in ISO RGD
GO_Central		 PMID:9350980 GO_REF:0000096 RGD:9850278 NCBI chr 3:157,272,459...157,350,392
Ensembl chr 3:157,272,529...157,351,525 		JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin involved_in ISO
IEA		 GO_Central
Ensembl		 GO_REF:0000107 GO_REF:0000119 NCBI chr 7:110,226,864...110,229,027
Ensembl chr 7:110,226,868...110,229,027 		JBrowse link
G Arr3 arrestin 3, retinal involved_in IBA GO_Central GO_REF:0000033 NCBI chr  X:99,649,086...99,662,099
Ensembl chr  X:99,649,103...99,662,099 		JBrowse link
G Arrb1 arrestin, beta 1 involved_in ISO
IBA		 GO_Central GO_REF:0000033 GO_REF:0000119 NCBI chr 7:99,184,356...99,255,979
Ensembl chr 7:99,184,673...99,255,978 		JBrowse link
G Arrb2 arrestin, beta 2 involved_in ISO
IEA
IBA		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000119 NCBI chr11:70,323,051...70,331,654
Ensembl chr11:70,323,461...70,331,654 		JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha involved_in ISO (PMID:10882736) UniProt PMID:10882736 NCBI chr 7:114,225,223...114,236,145
Ensembl chr 7:114,230,713...114,235,592 		JBrowse link
G Dnm1 dynamin 1 involved_in ISO RGD
GO_Central		 PMID:14709338 GO_REF:0000096 RGD:9685157 NCBI chr 2:32,198,483...32,243,361
Ensembl chr 2:32,198,483...32,243,350 		JBrowse link
G Dnm2 dynamin 2 involved_in ISO RGD
GO_Central		 PMID:14709338 GO_REF:0000096 RGD:9685157 NCBI chr 9:21,336,167...21,419,055
Ensembl chr 9:21,336,204...21,419,055 		JBrowse link
G Drd2 dopamine receptor D2 involved_in ISO
IEA		 RGD
Ensembl
GO_Central		 PMID:14617818 GO_REF:0000096 GO_REF:0000107 RGD:1581465 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Drd3 dopamine receptor D3 involved_in ISO RGD
GO_Central		 PMID:14617818 GO_REF:0000096 GO_REF:0000119 RGD:1581465 NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295 		JBrowse link
G Grk4 G protein-coupled receptor kinase 4 involved_in ISO RGD
GO_Central		 PMID:12519791 GO_REF:0000096 RGD:1304268 NCBI chr 5:34,817,641...34,912,649
Ensembl chr 5:34,817,723...34,912,649 		JBrowse link
G Gtf2h2 general transcription factor II H, polypeptide 2 involved_in ISO (PMID:15775968) UniProt PMID:15775968 NCBI chr13:100,596,726...100,629,123
Ensembl chr13:100,596,726...100,629,087 		JBrowse link
G Pld2 phospholipase D2 acts_upstream_of_or_within IDA (PMID:14718562) MGI PMID:14718562 NCBI chr11:70,430,318...70,448,936
Ensembl chr11:70,430,890...70,448,936 		JBrowse link
G Sag S-antigen, retina and pineal gland (arrestin) involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:87,731,402...87,772,880
Ensembl chr 1:87,731,402...87,772,880 		JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2b calcium/calmodulin-dependent protein kinase II, beta acts_upstream_of_or_within IDA (PMID:19332541) MGI PMID:19332541 NCBI chr11:5,919,642...6,016,401
Ensembl chr11:5,919,644...6,016,362 		JBrowse link
negative adaptation of signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Entrep1 endosomal transmembrane epsin interactor 1 involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr19:23,950,114...24,008,800
Ensembl chr19:23,950,114...24,008,383 		JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Necab2 N-terminal EF-hand calcium binding protein 2 involved_in IEA
ISO		 Ensembl
GO_Central		 GO_REF:0000107 GO_REF:0000119 NCBI chr 8:120,173,431...120,199,379
Ensembl chr 8:120,173,458...120,199,379 		JBrowse link
G Ubqln2 ubiquilin 2 involved_in ISO
ISS		 GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 NCBI chr  X:152,281,228...152,284,558
Ensembl chr  X:152,281,223...152,284,566 		JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apela apelin receptor early endogenous ligand involved_in ISO GO_Central GO_REF:0000119 NCBI chr 8:65,481,069...65,489,970
Ensembl chr 8:65,481,069...65,489,988 		JBrowse link
G Apln apelin involved_in ISO
IDA		 (PMID:11359874) GO_Central
UniProt		 PMID:11359874 GO_REF:0000096 GO_REF:0000119 NCBI chr  X:47,114,023...47,123,730
Ensembl chr  X:47,114,023...47,123,730 		JBrowse link
G Aplnr apelin receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:84,966,704...84,970,267
Ensembl chr 2:84,966,569...84,970,267 		JBrowse link
G App amyloid beta precursor protein involved_in ISO GO_Central GO_REF:0000119 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplnr apelin receptor involved_in ISO GO_Central GO_REF:0000119 NCBI chr 2:84,966,704...84,970,267
Ensembl chr 2:84,966,569...84,970,267 		JBrowse link
G Ptger3 prostaglandin E receptor 3 (subtype EP3) involved_in ISO RGD
GO_Central		 PMID:15937517 GO_REF:0000096 RGD:10043344 NCBI chr 3:157,272,459...157,350,392
Ensembl chr 3:157,272,529...157,351,525 		JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger3 prostaglandin E receptor 3 (subtype EP3) involved_in ISO RGD
GO_Central		 PMID:15937517 GO_REF:0000096 RGD:10043344 NCBI chr 3:157,272,459...157,350,392
Ensembl chr 3:157,272,529...157,351,525 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28640
    cellular process 18404
      signal transduction 6967
        regulation of signal transduction 3449
          adaptation of signaling pathway 29
            adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion + 0
            negative adaptation of signaling pathway + 29
            positive adaptation of signaling pathway 0
Path 2
Term Annotations click to browse term
  biological_process 28640
    biological regulation 13474
      regulation of biological process 13033
        signaling 7549
          regulation of signaling 4027
            regulation of signal transduction 3449
              adaptation of signaling pathway 29
                adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion + 0
                negative adaptation of signaling pathway + 29
                positive adaptation of signaling pathway 0
paths to the root