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ONTOLOGY REPORT - ANNOTATIONS

Term:adaptation of signaling pathway
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Accession:GO:0023058 term browser browse the term
Definition:The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.
Synonyms:exact_synonym: adaptation of signalling pathway


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desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARRB2 arrestin beta 2 involved_in IMP (PMID:12582207) UniProt PMID:12582207 NCBI chr17:4,710,632...4,721,497
Ensembl chr17:4,710,596...4,721,499 		JBrowse link
G GIPR gastric inhibitory polypeptide receptor involved_in ISO
IEA		 RGD
Ensembl		 PMID:8928774 GO_REF:0000107 RGD:2312614 NCBI chr19:45,668,221...45,683,722
Ensembl chr19:45,668,221...45,683,722 		JBrowse link
G GRK2 G protein-coupled receptor kinase 2 acts_upstream_of_or_within
involved_in		 ISO
IBA
IMP
IEA
ISS		 (PMID:7761854)
(PMID:10338466)
(PMID:15102938)		 RGD
MGI
GO_Central
UniProt
Ensembl
BHF-UCL		 PMID:7761854 PMID:10338466 PMID:15102938 PMID:17908240 PMID:30075183 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 RGD:13792694 RGD:7242040 NCBI chr11:67,266,473...67,286,556
Ensembl chr11:67,266,473...67,286,556 		JBrowse link
G GRK3 G protein-coupled receptor kinase 3 involved_in ISO
IBA		 RGD
GO_Central		 PMID:8381966 PMID:20837135 GO_REF:0000033 RGD:5685022 RGD:5685621 NCBI chr22:25,564,675...25,729,294
Ensembl chr22:25,564,675...25,729,294 		JBrowse link
G GRK4 G protein-coupled receptor kinase 4 ISO RGD PMID:15166006 RGD:1598508 NCBI chr 4:2,963,571...3,040,760
Ensembl chr 4:2,963,571...3,040,760 		JBrowse link
G GRK5 G protein-coupled receptor kinase 5 ISO RGD PMID:8626574 PMID:30075183 RGD:13792694 RGD:61618 NCBI chr10:119,207,571...119,459,745
Ensembl chr10:119,207,571...119,459,745 		JBrowse link
G GRK6 G protein-coupled receptor kinase 6 ISO RGD PMID:12810562 PMID:17908240 RGD:1299124 RGD:7242040 NCBI chr 5:177,425,523...177,442,891
Ensembl chr 5:177,403,204...177,442,901 		JBrowse link
G GRM5 glutamate metabotropic receptor 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:88,504,642...89,065,982
Ensembl chr11:88,504,576...89,065,982 		JBrowse link
G LY6G6E lymphocyte antigen 6 family member G6E (pseudogene) involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:26276394) GO_Central
MGI		 PMID:26276394 GO_REF:0000033 NCBI chr 6:31,711,976...31,714,065
Ensembl chr 6:31,712,341...31,713,812 		JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:9350980 RGD:9850278 NCBI chr 1:70,852,358...71,047,816
Ensembl chr 1:70,852,353...71,047,816 		JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADM adrenomedullin involved_in IDA (PMID:10882736) UniProt PMID:10882736 NCBI chr11:10,305,073...10,307,397
Ensembl chr11:10,305,073...10,307,397 		JBrowse link
G ARR3 arrestin 3 involved_in IBA GO_Central GO_REF:0000033 NCBI chr  X:70,268,334...70,281,883
Ensembl chr  X:70,268,305...70,281,840 		JBrowse link
G ARRB1 arrestin beta 1 involved_in IMP
IBA		 (PMID:10521508), (PMID:12582207) UniProt
GO_Central		 PMID:10521508 PMID:12582207 GO_REF:0000033 NCBI chr11:75,260,122...75,351,661
Ensembl chr11:75,260,122...75,351,705 		JBrowse link
G ARRB2 arrestin beta 2 involved_in TAS
IBA
IMP
IDA		 (PMID:24157794)
(PMID:12582207)
(PMID:10644702)		 ParkinsonsUK-UCL
GO_Central
UniProt		 PMID:10644702 PMID:12582207 PMID:24157794 GO_REF:0000033 NCBI chr17:4,710,632...4,721,497
Ensembl chr17:4,710,596...4,721,499 		JBrowse link
G CALCA calcitonin related polypeptide alpha involved_in IDA (PMID:10882736) UniProt PMID:10882736 NCBI chr11:14,966,668...14,972,351
Ensembl chr11:14,966,622...14,972,354 		JBrowse link
G DNM1 dynamin 1 ISO RGD PMID:14709338 RGD:9685157 NCBI chr 9:128,203,379...128,255,244
Ensembl chr 9:128,191,655...128,255,248 		JBrowse link
G DNM2 dynamin 2 ISO RGD PMID:14709338 RGD:9685157 NCBI chr19:10,718,079...10,831,903
Ensembl chr19:10,718,055...10,833,488 		JBrowse link
G DRD2 dopamine receptor D2 involved_in ISO
IEA		 RGD
Ensembl		 PMID:14617818 GO_REF:0000107 RGD:1581465 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691 		JBrowse link
G DRD3 dopamine receptor D3 involved_in ISO
IDA		 (PMID:18424554) RGD
BHF-UCL		 PMID:14617818 PMID:18424554 RGD:1581465 NCBI chr 3:114,127,580...114,199,407
Ensembl chr 3:114,127,580...114,199,407 		JBrowse link
G GRK4 G protein-coupled receptor kinase 4 ISO RGD PMID:12519791 RGD:1304268 NCBI chr 4:2,963,571...3,040,760
Ensembl chr 4:2,963,571...3,040,760 		JBrowse link
G GTF2H2 general transcription factor IIH subunit 2 involved_in IMP (PMID:15775968) UniProt PMID:15775968 NCBI chr 5:71,035,347...71,067,676
Ensembl chr 5:71,035,016...71,067,689 		JBrowse link
G GTF2H2C GTF2H2 family member C involved_in IMP (PMID:15775968) UniProt PMID:15775968 NCBI chr 5:69,560,191...69,595,221
Ensembl chr 5:69,560,191...69,595,221
Ensembl chr 5:69,560,191...69,595,221 		JBrowse link
G PLD2 phospholipase D2 acts_upstream_of_or_within ISO (PMID:14718562) MGI PMID:14718562 NCBI chr17:4,807,152...4,823,430
Ensembl chr17:4,807,152...4,823,434 		JBrowse link
G SAG S-antigen visual arrestin involved_in IBA GO_Central GO_REF:0000033 NCBI chr 2:233,307,816...233,347,055
Ensembl chr 2:233,307,816...233,347,055 		JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAMK2B calcium/calmodulin dependent protein kinase II beta acts_upstream_of_or_within ISO (PMID:19332541) MGI PMID:19332541 NCBI chr 7:44,217,154...44,326,013
Ensembl chr 7:44,210,019...44,334,577 		JBrowse link
negative adaptation of signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENTREP1 endosomal transmembrane epsin interactor 1 involved_in IMP (PMID:34927784) UniProt PMID:34927784 NCBI chr 9:69,324,567...69,392,456
Ensembl chr 9:69,324,567...69,392,558 		JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NECAB2 N-terminal EF-hand calcium binding protein 2 involved_in IDA (PMID:17689978) UniProt PMID:17689978 NCBI chr16:83,965,177...84,002,776
Ensembl chr16:83,968,244...84,002,776 		JBrowse link
G UBQLN2 ubiquilin 2 involved_in IMP (PMID:18199683) UniProt PMID:18199683 NCBI chr  X:56,563,627...56,567,868
Ensembl chr  X:56,563,627...56,567,868 		JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APELA apelin receptor early endogenous ligand involved_in IMP (PMID:25639753) UniProt PMID:25639753 NCBI chr 4:164,877,178...164,899,007
Ensembl chr 4:164,877,178...164,898,965 		JBrowse link
G APLN apelin involved_in IDA
IEA		 (PMID:11359874) UniProt
Ensembl		 PMID:11359874 GO_REF:0000107 NCBI chr  X:129,645,259...129,654,956
Ensembl chr  X:129,645,259...129,654,956 		JBrowse link
G APLNR apelin receptor involved_in IMP (PMID:25639753) UniProt PMID:25639753 NCBI chr11:57,233,591...57,237,250
Ensembl chr11:57,233,577...57,237,250 		JBrowse link
G APP amyloid beta precursor protein involved_in IDA (PMID:18723082) ARUK-UCL PMID:18723082 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128 		JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chr 1:70,852,358...71,047,816
Ensembl chr 1:70,852,353...71,047,816 		JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chr 1:70,852,358...71,047,816
Ensembl chr 1:70,852,353...71,047,816 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 27213
    cellular process 19795
      signal transduction 6641
        regulation of signal transduction 3507
          adaptation of signaling pathway 30
            adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion + 0
            negative adaptation of signaling pathway + 30
            positive adaptation of signaling pathway 0
Path 2
Term Annotations click to browse term
  biological_process 27213
    biological regulation 13724
      regulation of biological process 13268
        signaling 7242
          regulation of signaling 4075
            regulation of signal transduction 3507
              adaptation of signaling pathway 30
                adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion + 0
                negative adaptation of signaling pathway + 30
                positive adaptation of signaling pathway 0
paths to the root