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ONTOLOGY REPORT - ANNOTATIONS

Term:adaptation of signaling pathway
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Accession:GO:0023058 term browser browse the term
Definition:The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.
Synonyms:exact_synonym: adaptation of signalling pathway


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desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARRB2 arrestin beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:31,831,208...31,838,875
Ensembl chr 5:31,829,864...31,839,454 		JBrowse link
G GIPR gastric inhibitory polypeptide receptor ISO RGD PMID:8928774 RGD:2312614 NCBI chr 1:109,898,617...109,909,331
Ensembl chr 1:109,899,874...109,909,410 		JBrowse link
G GRK2 G protein-coupled receptor kinase 2 involved_in
acts_upstream_of_or_within		 ISO
IBA
IEA		 (PMID:7761854)
(PMID:10338466)		 RGD
GO_Central
MGI
Ensembl		 PMID:7761854 PMID:10338466 PMID:17908240 PMID:30075183 GO_REF:0000033 GO_REF:0000107 RGD:13792694 RGD:7242040 NCBI chr18:50,148,566...50,167,422
Ensembl chr18:50,148,598...50,167,428 		JBrowse link
G GRK3 G protein-coupled receptor kinase 3 involved_in ISO
IBA		 RGD
GO_Central		 PMID:8381966 PMID:20837135 GO_REF:0000033 RGD:5685022 RGD:5685621 NCBI chr26:19,385,059...19,512,528
Ensembl chr26:19,385,058...19,516,077 		JBrowse link
G GRK4 G protein-coupled receptor kinase 4 ISO RGD PMID:15166006 RGD:1598508 NCBI chr 3:61,233,066...61,331,094
Ensembl chr 3:61,079,904...61,330,290 		JBrowse link
G GRK5 G protein-coupled receptor kinase 5 ISO RGD PMID:8626574 PMID:30075183 RGD:13792694 RGD:61618 NCBI chr28:29,424,350...29,636,552
Ensembl chr28:29,424,593...29,632,741 		JBrowse link
G GRK6 G protein-coupled receptor kinase 6 ISO RGD PMID:12810562 PMID:17908240 RGD:1299124 RGD:7242040 NCBI chr 4:35,927,470...35,943,218
Ensembl chr 4:35,913,472...35,943,221 		JBrowse link
G GRM5 glutamate metabotropic receptor 5 involved_in ISO PMID:12514208 UniProt PMID:12514208 RGD:728711 NCBI chr21:10,980,186...11,496,539
Ensembl chr21:10,996,075...11,493,290 		JBrowse link
G LOC102154767 lymphocyte antigen 6G6e-like acts_upstream_of_or_within
involved_in		 ISO
IBA
IEA		 (PMID:26276394) MGI
GO_Central
Ensembl		 PMID:26276394 GO_REF:0000033 GO_REF:0000107 NCBI chr12:1,189,910...1,196,762 JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:9350980 RGD:9850278 NCBI chr 6:74,932,789...74,986,573 JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADM adrenomedullin involved_in ISO (PMID:10882736) UniProt PMID:10882736 NCBI chr21:33,472,197...33,474,472
Ensembl chr21:33,471,623...33,474,495 		JBrowse link
G ARR3 arrestin 3 involved_in IBA GO_Central GO_REF:0000033 NCBI chr  X:54,725,034...54,730,920
Ensembl chr  X:54,718,323...54,730,852 		JBrowse link
G ARRB1 arrestin beta 1 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr21:23,261,020...23,304,448
Ensembl chr21:23,235,711...23,297,786 		JBrowse link
G ARRB2 arrestin beta 2 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:31,831,208...31,838,875
Ensembl chr 5:31,829,864...31,839,454 		JBrowse link
G CRSP-3 calcitonin receptor-stimulating peptide 3 involved_in ISO (PMID:10882736) UniProt PMID:10882736 NCBI chr21:37,676,841...37,680,643
Ensembl chr21:37,676,841...37,680,645 		JBrowse link
G DNM1 dynamin 1 ISO RGD PMID:14709338 RGD:9685157 NCBI chr 9:55,252,802...55,298,244
Ensembl chr 9:55,252,347...55,298,244 		JBrowse link
G DNM2 dynamin 2 ISO RGD PMID:14709338 RGD:9685157 NCBI chr20:50,398,866...50,487,303
Ensembl chr20:50,398,864...50,487,241 		JBrowse link
G DRD2 dopamine receptor D2 ISO RGD PMID:14617818 RGD:1581465 NCBI chr 5:19,732,842...19,795,241
Ensembl chr 5:19,732,836...19,795,241 		JBrowse link
G DRD3 dopamine receptor D3 involved_in ISO
IEA		 RGD
Ensembl		 PMID:14617818 GO_REF:0000107 RGD:1581465 NCBI chr33:18,369,362...18,414,465
Ensembl chr33:18,372,865...18,412,277 		JBrowse link
G GRK4 G protein-coupled receptor kinase 4 ISO RGD PMID:12519791 RGD:1304268 NCBI chr 3:61,233,066...61,331,094
Ensembl chr 3:61,079,904...61,330,290 		JBrowse link
G LOC478089 general transcription factor IIH subunit 2 involved_in ISO (PMID:15775968) UniProt PMID:15775968 NCBI chr 2:54,553,871...54,579,695
Ensembl chr 2:54,554,578...54,628,670 		JBrowse link
G PLD2 phospholipase D2 acts_upstream_of_or_within ISO (PMID:14718562) MGI PMID:14718562 NCBI chr 5:31,755,881...31,767,131
Ensembl chr 5:31,756,433...31,767,066 		JBrowse link
G SAG S-antigen visual arrestin involved_in IBA GO_Central GO_REF:0000033 NCBI chr25:44,800,141...44,843,580
Ensembl chr25:44,812,362...44,843,579 		JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAMK2B calcium/calmodulin dependent protein kinase II beta acts_upstream_of_or_within ISO (PMID:19332541) MGI PMID:19332541
negative adaptation of signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENTREP1 endosomal transmembrane epsin interactor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:88,004,174...88,067,491
Ensembl chr 1:88,004,615...88,067,495 		JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NECAB2 N-terminal EF-hand calcium binding protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:68,313,699...68,342,253
Ensembl chr 5:68,314,000...68,378,311 		JBrowse link
G UBQLN2 ubiquilin 2 involved_in ISO (PMID:18199683) UniProt PMID:18199683 NCBI chr  X:47,860,923...47,864,282 JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APELA apelin receptor early endogenous ligand involved_in ISO (PMID:25639753) UniProt PMID:25639753 NCBI chr15:60,967,944...60,990,955 JBrowse link
G APLN apelin involved_in ISO (PMID:11359874) UniProt PMID:11359874 RGD:12907555 NCBI chr  X:100,863,360...100,873,105 JBrowse link
G APLNR apelin receptor involved_in ISO (PMID:25639753) UniProt PMID:25639753 NCBI chr18:38,878,621...38,882,280
Ensembl chr18:38,878,947...38,886,206 		JBrowse link
G APP amyloid beta precursor protein involved_in ISO (PMID:18723082) ARUK-UCL PMID:18723082 NCBI chr31:21,351,207...21,614,466
Ensembl chr31:21,351,207...21,614,337 		JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chr 6:74,932,789...74,986,573 JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chr 6:74,932,789...74,986,573 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 22117
    cellular process 21647
      signal transduction 6382
        regulation of signal transduction 3239
          adaptation of signaling pathway 29
            adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion + 0
            negative adaptation of signaling pathway + 29
            positive adaptation of signaling pathway 0
Path 2
Term Annotations click to browse term
  biological_process 22117
    biological regulation 12551
      regulation of biological process 12165
        signaling 6932
          regulation of signaling 3787
            regulation of signal transduction 3239
              adaptation of signaling pathway 29
                adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion + 0
                negative adaptation of signaling pathway + 29
                positive adaptation of signaling pathway 0
paths to the root