Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:adaptation of signaling pathway
go back to main search page
Accession:GO:0023058 term browser browse the term
Definition:The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.
Synonyms:exact_synonym: adaptation of signalling pathway


show annotations for term's descendants           Sort by:
desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARRB2 arrestin beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:4,766,616...4,777,253
Ensembl chr17:4,757,048...4,767,517 		JBrowse link
G GIPR gastric inhibitory polypeptide receptor ISO RGD PMID:8928774 RGD:2312614 NCBI chr19:42,673,553...42,688,059
Ensembl chr19:51,213,090...51,225,293 		JBrowse link
G GRK2 G protein-coupled receptor kinase 2 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:7761854)
(PMID:10338466)		 RGD
TreeGrafter
MGI
Ensembl		 PMID:7761854 PMID:10338466 PMID:17908240 PMID:30075183 GO_REF:0000107 GO_REF:0000118 RGD:13792694 RGD:7242040 NCBI chr11:62,624,647...62,644,846
Ensembl chr11:65,939,164...65,959,066 		JBrowse link
G GRK3 G protein-coupled receptor kinase 3 involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:8381966 PMID:20837135 GO_REF:0000118 RGD:5685022 RGD:5685621 NCBI chr22:6,579,664...6,789,846
Ensembl chr22:24,353,533...24,509,560 		JBrowse link
G GRK4 G protein-coupled receptor kinase 4 ISO RGD PMID:15166006 RGD:1598508 NCBI chr 4:3,106,064...3,181,270
Ensembl chr 4:3,008,126...3,083,094 		JBrowse link
G GRK5 G protein-coupled receptor kinase 5 ISO RGD PMID:8626574 PMID:30075183 RGD:13792694 RGD:61618 NCBI chr10:115,776,236...116,026,221
Ensembl chr10:119,200,688...119,450,809 		JBrowse link
G GRK6 G protein-coupled receptor kinase 6 ISO RGD PMID:12810562 PMID:17908240 RGD:1299124 RGD:7242040 NCBI chr 5:172,704,978...172,744,907
Ensembl chr 5:179,790,662...179,807,410 		JBrowse link
G GRM5 glutamate metabotropic receptor 5 involved_in ISO PMID:12514208 UniProt PMID:12514208 RGD:728711 NCBI chr11:83,514,978...84,077,650
Ensembl chr11:87,107,788...87,868,953 		JBrowse link
G LOC106634867 lymphocyte antigen 6G6e-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:31,373,400...31,375,471
Ensembl chr 6:32,262,222...32,264,007 		JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:9350980 RGD:9850278 NCBI chr 1:70,076,610...70,271,475
Ensembl chr 1:72,059,441...72,254,063 		JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADM adrenomedullin involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:10,437,712...10,440,053
Ensembl chr11:10,165,418...10,167,842 		JBrowse link
G ARR3 arrestin 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr  X:59,536,796...59,550,274
Ensembl chr  X:69,596,163...69,609,624 		JBrowse link
G ARRB1 arrestin beta 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr11:70,319,935...70,411,276
Ensembl chr11:73,630,276...73,654,155 		JBrowse link
G ARRB2 arrestin beta 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr17:4,766,616...4,777,253
Ensembl chr17:4,757,048...4,767,517 		JBrowse link
G CALCA calcitonin related polypeptide alpha involved_in ISO (PMID:10882736) UniProt PMID:10882736 NCBI chr11:15,055,897...15,061,539
Ensembl chr11:14,745,588...14,751,267 		JBrowse link
G DNM1 dynamin 1 ISO RGD PMID:14709338 RGD:9685157 NCBI chr 9:99,324,385...99,376,262
Ensembl chr 9:128,004,508...128,044,690 		JBrowse link
G DNM2 dynamin 2 ISO RGD PMID:14709338 RGD:9685157 NCBI chr19:10,272,172...10,386,032
Ensembl chr19:10,933,672...11,106,478 		JBrowse link
G DRD2 dopamine receptor D2 ISO RGD PMID:14617818 RGD:1581465 NCBI chr11:108,289,838...108,357,174
Ensembl chr11:112,132,703...112,198,935 		JBrowse link
G DRD3 dopamine receptor D3 involved_in ISO
IEA		 RGD
Ensembl		 PMID:14617818 GO_REF:0000107 RGD:1581465 NCBI chr 3:111,265,834...111,317,176
Ensembl chr 3:118,187,636...118,237,403 		JBrowse link
G GRK4 G protein-coupled receptor kinase 4 ISO RGD PMID:12519791 RGD:1304268 NCBI chr 4:3,106,064...3,181,270
Ensembl chr 4:3,008,126...3,083,094 		JBrowse link
G LOC100987487 general transcription factor IIH subunit 2 involved_in ISO (PMID:15775968) UniProt PMID:15775968 NCBI chr 5:44,412,653...44,445,158 JBrowse link
G PLD2 phospholipase D2 acts_upstream_of_or_within ISO (PMID:14718562) MGI PMID:14718562 NCBI chr17:4,853,919...4,870,254
Ensembl chr17:4,843,217...4,858,425 		JBrowse link
G SAG S-antigen visual arrestin involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr2B:120,532,049...120,574,914
Ensembl chr2B:239,449,910...239,487,537 		JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAMK2B calcium/calmodulin dependent protein kinase II beta acts_upstream_of_or_within ISO (PMID:19332541) MGI PMID:19332541 NCBI chr 7:44,930,859...45,040,078
Ensembl chr 7:45,001,267...45,110,342 		JBrowse link
negative adaptation of signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENTREP1 endosomal transmembrane epsin interactor 1 involved_in ISO (PMID:34927784) UniProt PMID:34927784 NCBI chr 9:55,400,544...55,468,662 JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NECAB2 N-terminal EF-hand calcium binding protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:64,636,198...64,670,019
Ensembl chr16:83,983,626...84,013,436 		JBrowse link
G UBQLN2 ubiquilin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:48,829,844...48,835,040
Ensembl chr  X:56,981,985...56,983,859 		JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APELA apelin receptor early endogenous ligand involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:157,125,485...157,145,999
Ensembl chr 4:169,176,910...169,195,553 		JBrowse link
G APLN apelin involved_in ISO (PMID:11359874) UniProt PMID:11359874 RGD:12907555 NCBI chr  X:118,775,509...118,785,224 JBrowse link
G APLNR apelin receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:52,475,088...52,479,102
Ensembl chr 3:159,967,360...159,968,502 		JBrowse link
G APP amyloid beta precursor protein involved_in ISO (PMID:18723082) ARUK-UCL PMID:18723082 NCBI chr21:12,324,455...12,608,594
Ensembl chr21:25,684,355...25,995,072 		JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chr 1:70,076,610...70,271,475
Ensembl chr 1:72,059,441...72,254,063 		JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chr 1:70,076,610...70,271,475
Ensembl chr 1:72,059,441...72,254,063 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19312
    cellular process 18866
      signal transduction 5484
        regulation of signal transduction 3088
          adaptation of signaling pathway 29
            adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion + 0
            negative adaptation of signaling pathway + 29
            positive adaptation of signaling pathway 0
Path 2
Term Annotations click to browse term
  biological_process 19312
    biological regulation 11878
      regulation of biological process 11495
        signaling 5997
          regulation of signaling 3595
            regulation of signal transduction 3088
              adaptation of signaling pathway 29
                adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion + 0
                negative adaptation of signaling pathway + 29
                positive adaptation of signaling pathway 0
paths to the root