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ONTOLOGY REPORT - ANNOTATIONS


Term:adaptation of signaling pathway
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Accession:GO:0023058 term browser browse the term
Definition:The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.
Synonyms:exact_synonym: adaptation of signalling pathway



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adaptation of rhodopsin mediated signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rdh11 retinol dehydrogenase 11 acts_upstream_of_or_within ISO MGI:3586379 (MGI:3584215|PMID:15790565) RGD PMID:15790565 MGI:3584215 NCBI chr 6:97,979,377...97,995,252
Ensembl chr 6:97,979,378...97,995,252
JBrowse link
G Rs1 retinoschisin 1 acts_upstream_of_or_within ISO MGI:3056058 (MGI:3055638|PMID:15326152) RGD PMID:15326152 MGI:3055638 NCBI chr  X:33,963,657...33,992,115
Ensembl chr  X:33,963,657...33,992,115
JBrowse link
desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gipr gastric inhibitory polypeptide receptor IDA RGD PMID:8928774 RGD:2312614 NCBI chr 1:78,804,287...78,814,462
Ensembl chr 1:78,805,593...78,814,462
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 involved_in
acts_upstream_of_or_within
IC
IBA
IEA
ISO
IDA
IMP
PMID:21873635
GO_REF:0000107
(PMID:15102938)
MGI:2180127|MGI:87937 (MGI:1337704|PMID:10338466), (MGI:84440|PMID:7761854)
PMID:18223549
Ensembl
RGD
PMID:7761854 PMID:10338466 PMID:15102938 PMID:1403099 PMID:21873635 More... GO_REF:0000107 MGI:1337704 MGI:84440, RGD:632163, RGD:13792537, RGD:8553863, RGD:13792694, RGD:7242040 NCBI chr 1:201,581,480...201,601,580
Ensembl chr 1:201,581,480...201,601,582
JBrowse link
G Grk3 G protein-coupled receptor kinase 3 involved_in IC
IBA
IMP
IDA
PMID:21873635 RGD
GO_Central
PMID:1403099 PMID:21873635 PMID:8381966 PMID:20837135 RGD:632163, RGD:13792537, RGD:5685621, RGD:5685022 NCBI chr12:43,624,778...43,735,375
Ensembl chr12:43,624,897...43,731,262
JBrowse link
G Grk4 G protein-coupled receptor kinase 4 IMP RGD PMID:15166006 RGD:1598508 NCBI chr14:75,998,554...76,080,808
Ensembl chr14:76,006,218...76,080,693
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 IMP RGD PMID:8626574 PMID:30075183 RGD:61618, RGD:13792694 NCBI chr 1:260,028,269...260,223,699
Ensembl chr 1:260,028,242...260,218,701
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 IDA
IMP
RGD PMID:12810562 PMID:17908240 RGD:1299124, RGD:7242040 NCBI chr17:9,177,018...9,192,644
Ensembl chr17:9,177,019...9,192,644
JBrowse link
G Grm5 glutamate metabotropic receptor 5 involved_in IDA PMID:12514208 UniProt PMID:12514208 RGD:728711 NCBI chr 1:141,310,069...141,884,980
Ensembl chr 1:141,312,368...141,882,274
JBrowse link
G Ly6g6e lymphocyte antigen 6 family member G6E acts_upstream_of_or_within ISO (MGI:5694852|PMID:26276394) RGD PMID:26276394 MGI:5694852 NCBI chr20:3,744,999...3,749,867
Ensembl chr20:3,744,999...3,750,849
JBrowse link
G Ptger3 prostaglandin E receptor 3 IMP RGD PMID:9350980 RGD:9850278 NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434
JBrowse link
desensitization of G protein-coupled receptor signaling pathway by arrestin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 involved_in ISO (PMID:15123695) RGD PMID:15123695 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Adrb3 adrenoceptor beta 3 NOT|involved_in ISO (PMID:15123695) RGD PMID:15123695 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552
JBrowse link
G Arrb2 arrestin, beta 2 involved_in IMP
ISO
(PMID:12582207) RGD PMID:12582207 PMID:20705669 RGD:5509896 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin involved_in ISO (PMID:10882736) RGD PMID:10882736 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Arr3 arrestin 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:65,699,881...65,712,224
Ensembl chr  X:65,698,699...65,712,153
JBrowse link
G Arrb1 arrestin, beta 1 involved_in IBA
ISO
PMID:21873635
(PMID:10521508), (PMID:12582207)
RGD PMID:10521508 PMID:12582207 PMID:21873635 RGD:13792537 NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061
JBrowse link
G Arrb2 arrestin, beta 2 involved_in IBA
ISO
PMID:21873635
(PMID:10644702), (PMID:12582207)
RGD PMID:10644702 PMID:12582207 PMID:21873635 RGD:13792537 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Calca calcitonin-related polypeptide alpha involved_in ISO (PMID:10882736) RGD PMID:10882736 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Dnm1 dynamin 1 IMP RGD PMID:14709338 RGD:9685157 NCBI chr 3:15,604,782...15,648,654
Ensembl chr 3:15,604,784...15,648,538
JBrowse link
G Dnm2 dynamin 2 IMP RGD PMID:14709338 RGD:9685157 NCBI chr 8:19,978,313...20,060,162
Ensembl chr 8:19,978,400...20,060,157
JBrowse link
G Drd2 dopamine receptor D2 IDA RGD PMID:14617818 RGD:1581465 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Drd3 dopamine receptor D3 involved_in IDA
ISO
(PMID:18424554) RGD PMID:18424554 PMID:14617818 RGD:1581465 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Grk4 G protein-coupled receptor kinase 4 IMP RGD PMID:12519791 RGD:1304268 NCBI chr14:75,998,554...76,080,808
Ensembl chr14:76,006,218...76,080,693
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B involved_in ISO (MGI:4821070|PMID:17325130) RGD PMID:17325130 MGI:4821070 NCBI chr 8:82,513,572...82,534,892
Ensembl chr 8:82,517,360...82,534,549
JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B involved_in IEA
ISO
GO_REF:0000107
(MGI:4821070|PMID:17325130)
Ensembl
RGD
PMID:17325130 GO_REF:0000107 MGI:4821070 NCBI chr 9:86,735,793...86,756,640
Ensembl chr 9:86,742,102...86,755,108
JBrowse link
G Pld2 phospholipase D2 acts_upstream_of_or_within ISO (MGI:3042801|PMID:14718562) RGD PMID:14718562 MGI:3042801 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808
JBrowse link
G Sag S-antigen visual arrestin involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:88,467,797...88,508,821
Ensembl chr 9:88,469,376...88,508,820
JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2b calcium/calmodulin-dependent protein kinase II beta acts_upstream_of_or_within ISO (MGI:4352609|PMID:19332541) RGD PMID:19332541 MGI:4352609 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Necab2 N-terminal EF-hand calcium binding protein 2 involved_in ISO
IEA
(PMID:17689978)
GO_REF:0000107
RGD
Ensembl
PMID:17689978 GO_REF:0000107 NCBI chr19:47,501,351...47,527,722
Ensembl chr19:47,501,302...47,527,684
JBrowse link
G Ubqln2 ubiquilin 2 involved_in ISO (PMID:18199683) RGD PMID:18199683 NCBI chr  X:17,853,086...17,856,505
Ensembl chr  X:17,853,114...17,856,505
JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apela apelin receptor early endogenous ligand involved_in ISO (PMID:25639753) RGD PMID:25639753 NCBI chr16:24,694,231...24,703,466
Ensembl chr16:24,694,324...24,703,465
JBrowse link
G Apln apelin involved_in ISO
IDA
(PMID:11359874)
(MGI:5902690|PMID:11359874)
RGD PMID:11359874 PMID:11359874 MGI:5902690, RGD:12907555 NCBI chr  X:127,180,801...127,213,567
Ensembl chr  X:127,203,823...127,213,391
JBrowse link
G App amyloid beta precursor protein involved_in ISO (PMID:18723082) RGD PMID:18723082 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplnr apelin receptor involved_in ISS
ISO
GO_REF:0000024
(PMID:25639753)
UniProt
RGD
PMID:25639753 GO_REF:0000024 NCBI chr 3:70,217,407...70,221,052
Ensembl chr 3:70,217,385...70,221,050
JBrowse link
G Ptger3 prostaglandin E receptor 3 IMP RGD PMID:15937517 RGD:10043344 NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434
JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger3 prostaglandin E receptor 3 IMP RGD PMID:15937517 RGD:10043344 NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18737
    signaling 7370
      regulation of signaling 3613
        regulation of signal transduction 3083
          adaptation of signaling pathway 33
            adaptation of rhodopsin mediated signaling 2
            adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion + 0
            negative adaptation of signaling pathway + 31
            positive adaptation of signaling pathway 0
Path 2
Term Annotations click to browse term
  biological_process 18737
    biological regulation 13318
      regulation of biological process 12598
        regulation of cellular process 11911
          signal transduction 6808
            regulation of signal transduction 3083
              adaptation of signaling pathway 33
                adaptation of rhodopsin mediated signaling 2
                adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion + 0
                negative adaptation of signaling pathway + 31
                positive adaptation of signaling pathway 0
paths to the root