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ONTOLOGY REPORT - ANNOTATIONS


Term:adaptation of signaling pathway
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Accession:GO:0023058 term browser browse the term
Definition:The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.
Synonyms:exact_synonym: adaptation of signalling pathway



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desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin, beta 2 involved_in ISO (PMID:12582207) RGD PMID:12582207 NCBI chr10:55,645,539...55,653,485 JBrowse link
G Gipr gastric inhibitory polypeptide receptor IDA RGD PMID:8928774 RGD:2312614 NCBI chr 1:78,804,287...78,814,462 JBrowse link
G Grk2 G protein-coupled receptor kinase 2 acts_upstream_of_or_within
involved_in
IC
ISO
IBA
IEA
IDA
IMP
MGI:2180127|MGI:87937 (PMID:10338466), (PMID:7761854)
GO_REF:0000033
GO_REF:0000107
(PMID:15102938)
PMID:18223549
RGD
GO_Central
Ensembl
PMID:7761854 PMID:10338466 PMID:15102938 PMID:1403099 PMID:18223549 More... GO_REF:0000033 GO_REF:0000107, RGD:632163, RGD:8553863, RGD:13792694, RGD:7242040 NCBI chr 1:211,010,259...211,031,013 JBrowse link
G Grk3 G protein-coupled receptor kinase 3 involved_in IC
IBA
IMP
IDA
GO_REF:0000033 GO_Central
RGD
PMID:1403099 PMID:8381966 PMID:20837135 GO_REF:0000033, RGD:632163, RGD:5685621, RGD:5685022 NCBI chr12:49,285,228...49,395,803 JBrowse link
G Grk4 G protein-coupled receptor kinase 4 IMP RGD PMID:15166006 RGD:1598508 NCBI chr14:80,230,699...80,305,292 JBrowse link
G Grk5 G protein-coupled receptor kinase 5 IMP RGD PMID:8626574 PMID:30075183 RGD:61618, RGD:13792694 NCBI chr 1:270,014,314...270,208,294 JBrowse link
G Grk6 G protein-coupled receptor kinase 6 IDA
IMP
RGD PMID:12810562 PMID:17908240 RGD:1299124, RGD:7242040 NCBI chr17:9,182,160...9,198,380 JBrowse link
G Grm5 glutamate metabotropic receptor 5 involved_in IDA PMID:12514208 UniProt PMID:12514208 RGD:728711 NCBI chr 1:141,310,069...141,884,980 JBrowse link
G Ly6g6e lymphocyte antigen 6 family member G6E involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
(PMID:26276394)
GO_Central
RGD
PMID:26276394 GO_REF:0000033 NCBI chr20:3,749,352...3,752,578 JBrowse link
G Ptger3 prostaglandin E receptor 3 IMP RGD PMID:9350980 RGD:9850278 NCBI chr 2:246,606,131...246,750,970 JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin involved_in ISO (PMID:10882736) RGD PMID:10882736 NCBI chr 1:174,164,178...174,182,372 JBrowse link
G Arrb1 arrestin, beta 1 involved_in ISO
IBA
(PMID:10521508), (PMID:12582207)
GO_REF:0000033
RGD
GO_Central
PMID:10521508 PMID:12582207 GO_REF:0000033 NCBI chr 1:163,249,654...163,321,711 JBrowse link
G Arrb2 arrestin, beta 2 involved_in ISO
IBA
IEA
(PMID:10644702), (PMID:12582207)
GO_REF:0000033
GO_REF:0000107
RGD
GO_Central
Ensembl
PMID:10644702 PMID:12582207 GO_REF:0000033 GO_REF:0000107 NCBI chr10:55,645,539...55,653,485 JBrowse link
G Calca calcitonin-related polypeptide alpha involved_in ISO (PMID:10882736) RGD PMID:10882736 NCBI chr 1:178,312,636...178,317,588 JBrowse link
G Dnm1 dynamin 1 IMP RGD PMID:14709338 RGD:9685157 NCBI chr 3:36,002,535...36,055,220 JBrowse link
G Dnm2 dynamin 2 IMP RGD PMID:14709338 RGD:9685157 NCBI chr 8:28,254,344...28,336,297 JBrowse link
G Drd2 dopamine receptor D2 IDA RGD PMID:14617818 RGD:1581465 NCBI chr 8:58,605,403...58,669,339 JBrowse link
G Drd3 dopamine receptor D3 involved_in IDA
IEA
ISO
GO_REF:0000107
(PMID:18424554)
Ensembl
RGD
PMID:18424554 PMID:14617818 GO_REF:0000107, RGD:1581465 NCBI chr11:70,385,586...70,437,793 JBrowse link
G ENSRNOG00000063241 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Grk4 G protein-coupled receptor kinase 4 IMP RGD PMID:12519791 RGD:1304268 NCBI chr14:80,230,699...80,305,292 JBrowse link
G Gtf2h2 general transcription factor IIH subunit 2 involved_in ISO (PMID:15775968) RGD PMID:15775968 NCBI chr 2:31,623,752...31,652,697 JBrowse link
G Pld2 phospholipase D2 acts_upstream_of_or_within ISO (PMID:14718562) RGD PMID:14718562 NCBI chr10:55,754,957...55,772,819 JBrowse link
G Sag S-antigen visual arrestin involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:95,915,640...95,956,641 JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2b calcium/calmodulin-dependent protein kinase II beta acts_upstream_of_or_within ISO (PMID:19332541) RGD PMID:19332541 NCBI chr14:85,059,166...85,148,121 JBrowse link
negative adaptation of signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Entrep1 endosomal transmembrane epsin interactor 1 involved_in ISO (PMID:34927784) RGD PMID:34927784 NCBI chr 1:221,592,500...221,646,603 JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Necab2 N-terminal EF-hand calcium binding protein 2 involved_in ISO
IEA
(PMID:17689978)
GO_REF:0000107
RGD
Ensembl
PMID:17689978 GO_REF:0000107 NCBI chr19:47,501,351...47,527,722 JBrowse link
G Ubqln2 ubiquilin 2 involved_in ISO (PMID:18199683) RGD PMID:18199683 NCBI chr  X:17,853,086...17,856,505 JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apela apelin receptor early endogenous ligand involved_in ISO (PMID:25639753) RGD PMID:25639753 NCBI chr16:24,694,356...24,703,466 JBrowse link
G Apln apelin involved_in ISO
IDA
(PMID:11359874) RGD PMID:11359874 PMID:11359874 RGD:12907555 NCBI chr  X:132,058,739...132,091,518 JBrowse link
G Aplnr apelin receptor involved_in ISO (PMID:25639753) RGD PMID:25639753 NCBI chr 3:70,217,407...70,221,052 JBrowse link
G App amyloid beta precursor protein involved_in ISO (PMID:18723082) RGD PMID:18723082 NCBI chr11:37,506,207...37,724,351 JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger3 prostaglandin E receptor 3 IMP RGD PMID:15937517 RGD:10043344 NCBI chr 2:246,606,131...246,750,970 JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger3 prostaglandin E receptor 3 IMP RGD PMID:15937517 RGD:10043344 NCBI chr 2:246,606,131...246,750,970 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20534
    cellular process 19523
      signal transduction 7250
        regulation of signal transduction 3279
          adaptation of signaling pathway 29
            adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion + 0
            negative adaptation of signaling pathway + 29
            positive adaptation of signaling pathway 0
Path 2
Term Annotations click to browse term
  biological_process 20534
    biological regulation 13821
      regulation of biological process 13375
        signaling 7808
          regulation of signaling 3836
            regulation of signal transduction 3279
              adaptation of signaling pathway 29
                adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion + 0
                negative adaptation of signaling pathway + 29
                positive adaptation of signaling pathway 0
paths to the root