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ONTOLOGY REPORT - ANNOTATIONS

Term:extracellular matrix disassembly
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Accession:GO:0022617 term browser browse the term
Definition:A process that results in the breakdown of the extracellular matrix.
Synonyms:xref: Reactome:R-HSA-1474228 "Degradation of the extracellular matrix"

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extracellular matrix disassembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts15 ADAM metallopeptidase with thrombospondin type 1 motif 15 involved_in ISO (PMID:23233679) UniProt PMID:23233679 NCBI chrNW_004624812:4,814,753...4,839,843
Ensembl chrNW_004624812:4,814,644...4,839,944 		JBrowse link
G Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif 5 involved_in ISO (PMID:23233679) UniProt PMID:23233679 NCBI chrNW_004624745:14,890,111...14,934,972
Ensembl chrNW_004624745:14,896,340...14,935,016 		JBrowse link
G Capg capping actin protein, gelsolin like NOT|involved_in ISO (PMID:24236012) UniProt PMID:24236012 NCBI chrNW_004624749:17,706,582...17,764,087
Ensembl chrNW_004624749:17,723,715...17,746,346 		JBrowse link
G Cma1 chymase 1 involved_in ISO (PMID:27068509) BHF-UCL PMID:27068509 NCBI chrNW_004624820:8,021,965...8,024,763
Ensembl chrNW_004624820:8,021,959...8,024,851 		JBrowse link
G Eng endoglin involved_in ISO (PMID:18223685) BHF-UCL PMID:18223685 NCBI chrNW_004624760:7,703,979...7,735,636
Ensembl chrNW_004624760:7,703,820...7,734,457 		JBrowse link
G Exoc8 exocyst complex component 8 involved_in ISO (PMID:24344185) UniProt PMID:24344185 NCBI chrNW_004624775:18,397,418...18,403,669
Ensembl chrNW_004624775:18,397,673...18,399,823 		JBrowse link
G Flot1 flotillin 1 involved_in ISO (PMID:21119006) UniProt PMID:21119006 NCBI chrNW_004624754:24,992,961...25,000,463
Ensembl chrNW_004624754:24,992,929...25,003,759 		JBrowse link
G Gsn gelsolin NOT|involved_in ISO (PMID:24236012) UniProt PMID:24236012 NCBI chrNW_004624760:13,943,680...14,004,660
Ensembl chrNW_004624760:13,943,888...13,969,905 		JBrowse link
G Kif9 kinesin family member 9 involved_in ISO (PMID:21119006) UniProt PMID:21119006 NCBI chrNW_004624730:74,075,530...74,118,164
Ensembl chrNW_004624730:74,075,752...74,118,164 		JBrowse link
G Klk4 kallikrein related peptidase 4 acts_upstream_of_or_within
involved_in 		ISO
IEA 		(PMID:22243248) MGI
TreeGrafter		 PMID:22243248 GO_REF:0000118 NCBI chrNW_004624832:3,828,676...3,832,025
Ensembl chrNW_004624832:3,828,679...3,831,767 		JBrowse link
G Klk5 kallikrein related peptidase 5 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624832:3,795,405...3,804,192
Ensembl chrNW_004624832:3,796,532...3,803,973 		JBrowse link
G Lamc1 laminin subunit gamma 1 involved_in ISO (PMID:15159456) HGNC-UCL PMID:15159456 NCBI chrNW_004624814:10,572,026...10,701,805
Ensembl chrNW_004624814:10,570,356...10,701,977 		JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 involved_in ISO (PMID:24236012) UniProt PMID:24236012 NCBI chrNW_004624748:8,740,563...8,833,091
Ensembl chrNW_004624748:8,779,395...8,835,500 		JBrowse link
G Mmp13 matrix metallopeptidase 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624918:2,228,688...2,239,852 JBrowse link
G Mmp20 matrix metallopeptidase 20 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004624878:277,569...320,093
Ensembl chrNW_004624878:277,558...320,093 		JBrowse link
G Noxo1 NADPH oxidase organizer 1 involved_in ISO (PMID:19755710) UniProt PMID:19755710 NCBI chrNW_004624913:280,502...282,723
Ensembl chrNW_004624913:279,130...282,790 		JBrowse link
G Pbxip1 PBX homeobox interacting protein 1 acts_upstream_of_or_within ISO (PMID:30659184) MGI PMID:30659184 NCBI chrNW_004624885:2,526,072...2,535,618
Ensembl chrNW_004624885:2,528,222...2,535,795 		JBrowse link
G Plg plasminogen involved_in ISO (PMID:14699093) BHF-UCL PMID:14699093 NCBI chrNW_004624855:2,362,793...2,401,519
Ensembl chrNW_004624855:2,360,229...2,402,079 		JBrowse link
G Sh3pxd2b SH3 and PX domains 2B involved_in ISO (PMID:19755710) UniProt PMID:19755710 NCBI chrNW_004624733:17,577,262...17,686,212
Ensembl chrNW_004624733:17,577,336...17,688,155 		JBrowse link
G Washc1 WASH complex subunit 1 involved_in ISO (PMID:24344185) UniProt PMID:24344185 NCBI chrNW_004624828:249,994...269,347 JBrowse link
G Wdr72 WD repeat domain 72 acts_upstream_of_or_within ISO (PMID:26247047) MGI PMID:26247047 NCBI chrNW_004624731:7,186,570...7,365,900
Ensembl chrNW_004624731:7,205,335...7,367,112 		JBrowse link
basement membrane disassembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cma1 chymase 1 involved_in ISO (PMID:27068509) BHF-UCL PMID:27068509 NCBI chrNW_004624820:8,021,965...8,024,763
Ensembl chrNW_004624820:8,021,959...8,024,851 		JBrowse link
G Ctss cathepsin S involved_in ISO (PMID:22952693) BHF-UCL PMID:22952693 NCBI chrNW_004624772:18,421,905...18,446,857
Ensembl chrNW_004624772:18,419,736...18,438,786 		JBrowse link
G Hpn hepsin involved_in ISO (PMID:16908524) UniProt PMID:16908524 NCBI chrNW_004624794:8,426,005...8,439,758
Ensembl chrNW_004624794:8,421,791...8,439,782 		JBrowse link
negative regulation of extracellular matrix disassembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpp4 dipeptidyl peptidase 4 involved_in ISO (PMID:16651416) UniProt PMID:16651416 NCBI chrNW_004624732:3,460,529...3,535,252
Ensembl chrNW_004624732:3,460,118...3,535,249 		JBrowse link
G Fap fibroblast activation protein alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624732:3,273,339...3,346,207
Ensembl chrNW_004624732:3,275,025...3,345,977 		JBrowse link
positive regulation of extracellular matrix disassembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carmil2 capping protein regulator and myosin 1 linker 2 involved_in ISO (PMID:26466680), (PMID:26578515) UniProt PMID:26466680 PMID:26578515 NCBI chrNW_004624746:18,692,179...18,704,952
Ensembl chrNW_004624746:18,692,225...18,704,476 		JBrowse link
G Clasp1 cytoplasmic linker associated protein 1 involved_in ISO (PMID:24859005) UniProt PMID:24859005 NCBI chrNW_004624732:23,553,876...23,814,565
Ensembl chrNW_004624732:23,581,356...23,811,640 		JBrowse link
G Clasp2 cytoplasmic linker associated protein 2 involved_in ISO (PMID:24859005) UniProt PMID:24859005 NCBI chrNW_004624788:11,441,840...11,657,515
Ensembl chrNW_004624788:11,441,747...11,573,029 		JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 involved_in ISO (PMID:11723120) UniProt PMID:11723120 NCBI chrNW_004624826:1,225,217...1,255,889
Ensembl chrNW_004624826:1,173,621...1,249,692 		JBrowse link
G Fscn1 fascin actin-bundling protein 1 involved_in ISO (PMID:20137952) UniProt PMID:20137952 NCBI chrNW_004624740:28,038,216...28,047,252
Ensembl chrNW_004624740:28,036,731...28,047,364 		JBrowse link
G Il6 interleukin 6 involved_in ISO (PMID:26587789) ARUK-UCL PMID:26587789 NCBI chrNW_004624739:7,957,709...7,963,414
Ensembl chrNW_004624739:7,957,674...7,962,318 		JBrowse link
G Meltf melanotransferrin involved_in ISO (PMID:16713448) UniProt PMID:16713448 NCBI chrNW_004624730:61,967,868...61,990,576
Ensembl chrNW_004624730:61,971,877...61,988,902 		JBrowse link
G Pdpn podoplanin involved_in ISO (PMID:25486435) UniProt PMID:25486435 NCBI chrNW_004624764:163,370...192,770 JBrowse link
G Stat3 signal transducer and activator of transcription 3 acts_upstream_of ISO (PMID:23820254) BHF-UCL PMID:23820254 NCBI chrNW_004624795:1,648,235...1,680,788
Ensembl chrNW_004624795:1,648,080...1,681,200 		JBrowse link
G Tgfb2 transforming growth factor beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624835:2,363,059...2,436,536
Ensembl chrNW_004624835:2,363,139...2,437,643 		JBrowse link
regulation of extracellular matrix disassembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddr1 discoidin domain receptor tyrosine kinase 1 involved_in ISO (PMID:12065315) UniProt PMID:12065315 NCBI chrNW_004624754:24,881,439...24,905,633
Ensembl chrNW_004624754:24,880,496...24,896,995 		JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor ISO RGD PMID:16738537 RGD:2313717 NCBI chrNW_004624812:2,795,961...2,920,263
Ensembl chrNW_004624812:2,795,686...2,920,274 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 involved_in ISO (PMID:20876804) UniProt PMID:20876804 NCBI chrNW_004624733:12,964,893...12,979,198
Ensembl chrNW_004624733:12,964,746...12,976,732 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17647
    cellular process 17219
      cellular component organization or biogenesis 7010
        cellular component organization 6807
          cellular component disassembly 439
            extracellular matrix disassembly 38
              basement membrane disassembly + 3
              biofilm matrix disassembly 0
              negative regulation of extracellular matrix disassembly 2
              positive regulation of extracellular matrix disassembly 10
              regulation of extracellular matrix disassembly + 15
Path 2
Term Annotations click to browse term
  biological_process 17647
    cellular process 17219
      cellular component organization or biogenesis 7010
        cellular component organization 6807
          extracellular structure organization 320
            extracellular matrix organization 317
              extracellular matrix disassembly 38
                basement membrane disassembly + 3
                biofilm matrix disassembly 0
                negative regulation of extracellular matrix disassembly 2
                positive regulation of extracellular matrix disassembly 10
                regulation of extracellular matrix disassembly + 15
paths to the root