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ONTOLOGY REPORT - ANNOTATIONS


Term:negative adaptation of signaling pathway
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Accession:GO:0022401 term browser browse the term
Definition:The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.
Synonyms:exact_synonym: negative adaptation of signal transduction pathway;   negative adaptation of signalling pathway


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desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gipr gastric inhibitory polypeptide receptor IDA RGD PMID:8928774 RGD:2312614 NCBI chr 1:78,804,287...78,814,462 JBrowse link
G Grk2 G protein-coupled receptor kinase 2 involved_in
acts_upstream_of_or_within
IC
IEA
ISO
IBA
IDA
IMP
GO_REF:0000107
(PMID:15102938)
PMID:21873635
MGI:2180127|MGI:87937 (MGI:1337704|PMID:10338466), (MGI:84440|PMID:7761854)
PMID:18223549
Ensembl
RGD
PMID:7761854 PMID:10338466 PMID:15102938, PMID:1403099, PMID:21873635, PMID:18223549, PMID:30075183, PMID:17908240 GO_REF:0000107 MGI:1337704 MGI:84440, RGD:632163, RGD:13792537, RGD:8553863, RGD:13792694, RGD:7242040 NCBI chr 1:201,581,480...201,601,580 JBrowse link
G Grk3 G protein-coupled receptor kinase 3 involved_in IC
IBA
IMP
IDA
PMID:21873635 RGD
GO_Central
PMID:1403099, PMID:21873635, PMID:8381966, PMID:20837135 RGD:632163, RGD:13792537, RGD:5685621, RGD:5685022 NCBI chr12:43,624,778...43,735,375 JBrowse link
G Grk4 G protein-coupled receptor kinase 4 IMP RGD PMID:15166006 RGD:1598508 NCBI chr14:75,998,554...76,080,808 JBrowse link
G Grk5 G protein-coupled receptor kinase 5 IMP RGD PMID:8626574, PMID:30075183 RGD:61618, RGD:13792694 NCBI chr 1:260,028,269...260,223,699 JBrowse link
G Grk6 G protein-coupled receptor kinase 6 IDA
IMP
RGD PMID:12810562, PMID:17908240 RGD:1299124, RGD:7242040 NCBI chr17:9,177,018...9,192,644 JBrowse link
G Grm5 glutamate metabotropic receptor 5 involved_in IDA PMID:12514208 UniProt PMID:12514208 RGD:728711 NCBI chr 1:141,310,069...141,884,980 JBrowse link
G Ly6g6e lymphocyte antigen 6 family member G6E involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:5694852|PMID:26276394)
RGD PMID:26276394, PMID:21873635 MGI:5694852, RGD:13792537 NCBI chr20:3,744,999...3,749,867 JBrowse link
G Ptger3 prostaglandin E receptor 3 IMP RGD PMID:9350980 RGD:9850278 NCBI chr 2:246,606,131...246,750,970 JBrowse link
desensitization of G protein-coupled receptor signaling pathway by arrestin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 involved_in ISO
ISS
(PMID:15123695)
GO_REF:0000024
RGD
HGNC-UCL
PMID:15123695 GO_REF:0000024 NCBI chr18:55,642,459...55,644,501 JBrowse link
G Adrb3 adrenoceptor beta 3 NOT|involved_in ISO (PMID:15123695) RGD PMID:15123695 NCBI chr16:64,839,820...64,844,552 JBrowse link
G Arrb2 arrestin, beta 2 involved_in IMP
ISO
(PMID:12582207) RGD PMID:12582207, PMID:20705669 RGD:5509896 NCBI chr10:55,146,887...55,154,854 JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin involved_in ISO (PMID:10882736) RGD PMID:10882736 NCBI chr 1:164,745,484...164,747,655 JBrowse link
G Arr3 arrestin 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:65,699,881...65,712,224 JBrowse link
G Arrb1 arrestin, beta 1 involved_in IBA
ISO
PMID:21873635
(PMID:10521508), (PMID:12582207)
RGD PMID:10521508 PMID:12582207, PMID:21873635 RGD:13792537 NCBI chr 1:153,837,964...153,912,111 JBrowse link
G Arrb2 arrestin, beta 2 involved_in IBA
ISO
PMID:21873635
(PMID:10644702), (PMID:12582207)
RGD PMID:10644702 PMID:12582207, PMID:21873635 RGD:13792537 NCBI chr10:55,146,887...55,154,854 JBrowse link
G Calca calcitonin-related polypeptide alpha involved_in ISO (PMID:10882736) RGD PMID:10882736 NCBI chr 1:168,878,212...168,883,176 JBrowse link
G Dnm1 dynamin 1 IMP RGD PMID:14709338 RGD:9685157 NCBI chr 3:15,604,782...15,648,654 JBrowse link
G Dnm2 dynamin 2 IMP RGD PMID:14709338 RGD:9685157 NCBI chr 8:19,978,313...20,060,162 JBrowse link
G Drd2 dopamine receptor D2 IDA RGD PMID:14617818 RGD:1581465 NCBI chr 8:49,708,903...49,772,888 JBrowse link
G Drd3 dopamine receptor D3 involved_in IDA
ISO
(PMID:18424554) RGD PMID:18424554, PMID:14617818 RGD:1581465 NCBI chr11:56,879,689...56,931,901 JBrowse link
G Grk4 G protein-coupled receptor kinase 4 IMP RGD PMID:12519791 RGD:1304268 NCBI chr14:75,998,554...76,080,808 JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B involved_in ISO (MGI:4821070|PMID:17325130) RGD PMID:17325130 MGI:4821070 NCBI chr 8:82,513,572...82,534,892 JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B involved_in IEA
ISO
GO_REF:0000107
(MGI:4821070|PMID:17325130)
Ensembl
RGD
PMID:17325130 GO_REF:0000107 MGI:4821070 NCBI chr 9:86,735,793...86,756,640 JBrowse link
G Pld2 phospholipase D2 acts_upstream_of_or_within ISO (MGI:3042801|PMID:14718562) RGD PMID:14718562 MGI:3042801 NCBI chr10:55,256,326...55,274,192 JBrowse link
G Sag S-antigen visual arrestin involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:88,467,797...88,508,821 JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2b calcium/calmodulin-dependent protein kinase II beta acts_upstream_of_or_within ISO (MGI:4352609|PMID:19332541) RGD PMID:19332541 MGI:4352609 NCBI chr14:80,845,206...80,934,172 JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Necab2 N-terminal EF-hand calcium binding protein 2 involved_in ISO (PMID:17689978) RGD PMID:17689978 NCBI chr19:47,501,351...47,527,722 JBrowse link
G Ubqln2 ubiquilin 2 involved_in ISO (PMID:18199683) RGD PMID:18199683 NCBI chr  X:17,853,086...17,856,505 JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apela apelin receptor early endogenous ligand involved_in ISO (PMID:25639753) RGD PMID:25639753 NCBI chr16:24,694,231...24,703,466 JBrowse link
G Apln apelin involved_in ISO
IDA
(PMID:11359874)
(MGI:5902690|PMID:11359874)
RGD PMID:11359874, PMID:11359874 MGI:5902690, RGD:12907555 NCBI chr  X:127,180,801...127,213,567 JBrowse link
G App amyloid beta precursor protein involved_in ISO (PMID:18723082) RGD PMID:18723082 NCBI chr11:24,019,774...24,236,584 JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplnr apelin receptor involved_in ISS
ISO
GO_REF:0000024
(PMID:25639753)
UniProt
RGD
PMID:25639753 GO_REF:0000024 NCBI chr 3:70,217,407...70,221,052 JBrowse link
G Ptger3 prostaglandin E receptor 3 IMP RGD PMID:15937517 RGD:10043344 NCBI chr 2:246,606,131...246,750,970 JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger3 prostaglandin E receptor 3 IMP RGD PMID:15937517 RGD:10043344 NCBI chr 2:246,606,131...246,750,970 JBrowse link

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