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ONTOLOGY REPORT - ANNOTATIONS


Term:negative adaptation of signaling pathway
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Accession:GO:0022401 term browser browse the term
Definition:The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.
Synonyms:exact_synonym: negative adaptation of signal transduction pathway;   negative adaptation of signalling pathway


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desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GIPR gastric inhibitory polypeptide receptor involved_in IEA
ISO
Ensembl
RGD
PMID:8928774 GO_REF:0000107 RGD:2312614 NCBI chr19:45,668,187...45,683,722
Ensembl chr19:45,668,221...45,683,722
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 involved_in
acts_upstream_of_or_within
ISS
IMP
IBA
ISO
(PMID:15102938)
(PMID:21873635)
(MGI:1337704|PMID:10338466)
(MGI:84440|PMID:7761854)
BHF-UCL
UniProt
GO_Central
MGI
RGD
PMID:7761854 PMID:10338466 PMID:15102938 PMID:17908240 PMID:21873635 PMID:30075183 GO_REF:0000024 MGI:1337704 MGI:84440 RGD:13792694 RGD:7242040 NCBI chr11:67,266,420...67,286,556
Ensembl chr11:67,266,473...67,286,556
JBrowse link
G GRK3 G protein-coupled receptor kinase 3 involved_in ISO
IBA
(PMID:21873635) RGD
GO_Central
PMID:8381966 PMID:20837135 PMID:21873635 RGD:5685022 RGD:5685621 NCBI chr22:25,564,675...25,729,294
Ensembl chr22:25,564,675...25,729,294
JBrowse link
G GRK4 G protein-coupled receptor kinase 4 ISO RGD PMID:15166006 RGD:1598508 NCBI chr 4:2,963,504...3,040,760
Ensembl chr 4:2,963,571...3,040,760
JBrowse link
G GRK5 G protein-coupled receptor kinase 5 ISO RGD PMID:8626574 PMID:30075183 RGD:13792694 RGD:61618 NCBI chr10:119,207,571...119,459,745
Ensembl chr10:119,207,571...119,459,745
JBrowse link
G GRK6 G protein-coupled receptor kinase 6 ISO RGD PMID:12810562 PMID:17908240 RGD:1299124 RGD:7242040 NCBI chr 5:177,426,496...177,442,891
Ensembl chr 5:177,403,204...177,442,901
JBrowse link
G GRM5 glutamate metabotropic receptor 5 involved_in ISO PMID:12514208 UniProt PMID:12514208 RGD:728711 NCBI chr11:88,504,576...89,065,982
Ensembl chr11:88,504,576...89,065,982
JBrowse link
G LY6G6E lymphocyte antigen 6 family member G6E involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:5694852|PMID:26276394)
GO_Central
MGI
PMID:21873635 PMID:26276394 MGI:5694852 NCBI chr 6:31,711,976...31,714,065
Ensembl chr 6:31,711,771...31,714,065
JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:9350980 RGD:9850278 NCBI chr 1:70,852,358...71,047,816
Ensembl chr 1:70,852,353...71,047,808
JBrowse link
desensitization of G protein-coupled receptor signaling pathway by arrestin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB2 adrenoceptor beta 2 involved_in IDA (PMID:15123695) HGNC-UCL PMID:15123695 NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,826,611...148,828,623
JBrowse link
G ADRB3 adrenoceptor beta 3 NOT|involved_in IDA (PMID:15123695) HGNC-UCL PMID:15123695 NCBI chr 8:37,962,990...37,966,599
Ensembl chr 8:37,962,990...37,966,599
JBrowse link
G ARRB2 arrestin beta 2 involved_in IMP
ISO
(PMID:12582207) UniProt
RGD
PMID:12582207 PMID:20705669 RGD:5509896 NCBI chr17:4,710,619...4,721,500
Ensembl chr17:4,710,596...4,721,499
JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADM adrenomedullin involved_in IDA (PMID:10882736) UniProt PMID:10882736 NCBI chr11:10,305,073...10,307,397
Ensembl chr11:10,305,073...10,307,397
JBrowse link
G ARR3 arrestin 3 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  X:70,268,334...70,281,840
Ensembl chr  X:70,268,305...70,281,840
JBrowse link
G ARRB1 arrestin beta 1 involved_in IBA
IMP
(PMID:21873635)
(PMID:10521508), (PMID:12582207)
GO_Central
UniProt
PMID:10521508 PMID:12582207 PMID:21873635 NCBI chr11:75,260,122...75,351,662
Ensembl chr11:75,260,122...75,351,705
JBrowse link
G ARRB2 arrestin beta 2 involved_in IBA
TAS
IMP
IDA
(PMID:21873635)
(PMID:24157794)
(PMID:12582207)
(PMID:10644702)
GO_Central
ParkinsonsUK-UCL
UniProt
PMID:10644702 PMID:12582207 PMID:21873635 PMID:24157794 NCBI chr17:4,710,619...4,721,500
Ensembl chr17:4,710,596...4,721,499
JBrowse link
G CALCA calcitonin related polypeptide alpha involved_in IDA (PMID:10882736) UniProt PMID:10882736 NCBI chr11:14,966,668...14,972,361
Ensembl chr11:14,966,668...14,972,351
JBrowse link
G DNM1 dynamin 1 involved_in IEA
ISO
Ensembl
RGD
PMID:14709338 GO_REF:0000107 RGD:9685157 NCBI chr 9:128,203,379...128,255,244
Ensembl chr 9:128,191,655...128,255,248
JBrowse link
G DNM2 dynamin 2 involved_in IEA
ISO
Ensembl
RGD
PMID:14709338 GO_REF:0000107 RGD:9685157 NCBI chr19:10,718,079...10,831,903
Ensembl chr19:10,718,055...10,833,488
JBrowse link
G DRD2 dopamine receptor D2 involved_in IEA
ISO
Ensembl
RGD
PMID:14617818 GO_REF:0000107 RGD:1581465 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
JBrowse link
G DRD3 dopamine receptor D3 involved_in IDA
ISO
(PMID:18424554) BHF-UCL
RGD
PMID:14617818 PMID:18424554 RGD:1581465 NCBI chr 3:114,127,580...114,199,407
Ensembl chr 3:114,127,580...114,199,407
JBrowse link
G GRK4 G protein-coupled receptor kinase 4 involved_in IEA
ISO
Ensembl
RGD
PMID:12519791 GO_REF:0000107 RGD:1304268 NCBI chr 4:2,963,504...3,040,760
Ensembl chr 4:2,963,571...3,040,760
JBrowse link
G GTF2H2 general transcription factor IIH subunit 2 involved_in IMP (PMID:15775968) UniProt PMID:15775968 NCBI chr 5:71,035,124...71,109,113
Ensembl chr 5:71,032,670...71,067,689
JBrowse link
G HTR1B 5-hydroxytryptamine receptor 1B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:77,460,924...77,463,491
Ensembl chr 6:77,460,924...77,463,491
JBrowse link
G HTR2B 5-hydroxytryptamine receptor 2B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:231,108,230...231,126,172
Ensembl chr 2:231,108,230...231,125,042
JBrowse link
G PLD2 phospholipase D2 acts_upstream_of_or_within ISO (MGI:3042801|PMID:14718562) MGI PMID:14718562 MGI:3042801 NCBI chr17:4,807,152...4,823,432
Ensembl chr17:4,807,152...4,823,434
JBrowse link
G SAG S-antigen visual arrestin involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:233,307,816...233,347,066
Ensembl chr 2:233,307,816...233,347,055
JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAMK2B calcium/calmodulin dependent protein kinase II beta acts_upstream_of_or_within ISO (MGI:4352609|PMID:19332541) MGI PMID:19332541 MGI:4352609 NCBI chr 7:44,217,154...44,326,167
Ensembl chr 7:44,217,150...44,334,577
JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NECAB2 N-terminal EF-hand calcium binding protein 2 involved_in IDA (PMID:17689978) UniProt PMID:17689978 NCBI chr16:83,968,244...84,002,776
Ensembl chr16:83,968,244...84,002,776
JBrowse link
G UBQLN2 ubiquilin 2 involved_in IMP (PMID:18199683) UniProt PMID:18199683 NCBI chr  X:56,563,627...56,567,868
Ensembl chr  X:56,563,627...56,567,868
JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APELA apelin receptor early endogenous ligand involved_in IMP (PMID:25639753) UniProt PMID:25639753 NCBI chr 4:164,877,023...164,899,063
Ensembl chr 4:164,877,178...164,898,965
JBrowse link
G APLN apelin involved_in IDA (PMID:11359874) UniProt PMID:11359874 NCBI chr  X:129,645,259...129,654,956
Ensembl chr  X:129,645,259...129,654,956
JBrowse link
G APP amyloid beta precursor protein involved_in IDA (PMID:18723082) ARUK-UCL PMID:18723082 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLNR apelin receptor involved_in IMP (PMID:25639753) UniProt PMID:25639753 NCBI chr11:57,233,591...57,237,250
Ensembl chr11:57,233,577...57,237,235
JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chr 1:70,852,358...71,047,816
Ensembl chr 1:70,852,353...71,047,808
JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chr 1:70,852,358...71,047,816
Ensembl chr 1:70,852,353...71,047,808
JBrowse link

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