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ONTOLOGY REPORT - ANNOTATIONS


Term:negative adaptation of signaling pathway
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Accession:GO:0022401 term browser browse the term
Definition:The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.
Synonyms:exact_synonym: negative adaptation of signal transduction pathway;   negative adaptation of signalling pathway


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desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gipr gastric inhibitory polypeptide receptor ISO RGD PMID:8928774 RGD:2312614 NCBI chrNW_004955574:140,307...153,684
Ensembl chrNW_004955574:140,307...156,899
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 involved_in
acts_upstream_of_or_within
ISO (PMID:15102938)
(MGI:84440|PMID:7761854)
(MGI:1337704|PMID:10338466)
PMID:18223549
RGD
UniProt
MGI
BHF-UCL
PMID:7761854 PMID:10338466 PMID:15102938 PMID:17908240 PMID:18223549 PMID:30075183 MGI:1337704 MGI:84440 RGD:13792694 RGD:7242040 RGD:8553863 NCBI chrNW_004955422:18,173,438...18,192,357
Ensembl chrNW_004955422:18,170,616...18,192,412
JBrowse link
G Grk3 G protein-coupled receptor kinase 3 ISO RGD PMID:8381966 PMID:20837135 RGD:5685022 RGD:5685621 NCBI chrNW_004955442:19,640,145...19,785,803
Ensembl chrNW_004955442:19,640,145...19,785,803
JBrowse link
G Grk4 G protein-coupled receptor kinase 4 ISO RGD PMID:15166006 RGD:1598508 NCBI chrNW_004955514:1,837,141...1,895,785
Ensembl chrNW_004955514:1,837,141...1,895,785
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO RGD PMID:8626574 PMID:30075183 RGD:13792694 RGD:61618 NCBI chrNW_004955551:43,918...255,118
Ensembl chrNW_004955551:44,156...254,534
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 ISO RGD PMID:12810562 PMID:17908240 RGD:1299124 RGD:7242040 NCBI chrNW_004955408:29,665,534...29,684,225
Ensembl chrNW_004955408:29,665,260...29,684,207
JBrowse link
G Grm5 glutamate metabotropic receptor 5 involved_in ISO PMID:12514208 UniProt PMID:12514208 RGD:728711 NCBI chrNW_004955414:4,424,245...4,919,399 JBrowse link
G Ptger3 prostaglandin E receptor 3 ISO RGD PMID:9350980 RGD:9850278 NCBI chrNW_004955423:21,096,926...21,164,435 JBrowse link
desensitization of G protein-coupled receptor signaling pathway by arrestin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 involved_in ISO (PMID:15123695) HGNC-UCL PMID:15123695 NCBI chrNW_004955415:5,515,157...5,517,198
Ensembl chrNW_004955415:5,515,697...5,516,980
JBrowse link
G Adrb3 adrenoceptor beta 3 NOT|involved_in ISO (PMID:15123695) HGNC-UCL PMID:15123695 NCBI chrNW_004955463:13,663,064...13,665,553 JBrowse link
G Arrb2 arrestin beta 2 involved_in ISO (PMID:12582207) RGD
UniProt
PMID:12582207 PMID:20705669 RGD:5509896 NCBI chrNW_004955467:10,109,985...10,118,687
Ensembl chrNW_004955467:10,110,003...10,123,022
JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin involved_in ISO (PMID:10882736) UniProt PMID:10882736 NCBI chrNW_004955414:25,951,473...25,953,593
Ensembl chrNW_004955414:25,951,349...25,953,645
JBrowse link
G Arrb1 arrestin beta 1 involved_in ISO (PMID:10521508), (PMID:12582207) UniProt PMID:10521508 PMID:12582207 NCBI chrNW_004955414:16,478,843...16,568,050
Ensembl chrNW_004955414:16,478,843...16,562,135
JBrowse link
G Arrb2 arrestin beta 2 involved_in ISO (PMID:12582207)
(PMID:10644702)
UniProt PMID:10644702 PMID:12582207 NCBI chrNW_004955467:10,109,985...10,118,687
Ensembl chrNW_004955467:10,110,003...10,123,022
JBrowse link
G Dnm1 dynamin 1 ISO RGD PMID:14709338 RGD:9685157 NCBI chrNW_004955570:752,335...781,770
Ensembl chrNW_004955570:752,335...781,770
JBrowse link
G Dnm2 dynamin 2 ISO RGD PMID:14709338 RGD:9685157 NCBI chrNW_004955495:1,860,644...1,934,589
Ensembl chrNW_004955495:1,860,644...1,934,818
JBrowse link
G Drd2 dopamine receptor D2 ISO RGD PMID:14617818 RGD:1581465 NCBI chrNW_004955412:15,054,255...15,114,558
Ensembl chrNW_004955412:15,054,038...15,114,573
JBrowse link
G Drd3 dopamine receptor D3 involved_in ISO (PMID:18424554) RGD
BHF-UCL
PMID:14617818 PMID:18424554 RGD:1581465 NCBI chrNW_004955427:14,219,519...14,252,178
Ensembl chrNW_004955427:14,219,594...14,252,178
JBrowse link
G Grk4 G protein-coupled receptor kinase 4 ISO RGD PMID:12519791 RGD:1304268 NCBI chrNW_004955514:1,837,141...1,895,785
Ensembl chrNW_004955514:1,837,141...1,895,785
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B involved_in ISO (MGI:4821070|PMID:17325130) UniProt PMID:17325130 MGI:4821070 NCBI chrNW_004955502:5,640,919...5,646,899
Ensembl chrNW_004955502:5,645,644...5,646,816
JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B involved_in ISO (MGI:4821070|PMID:17325130) UniProt PMID:17325130 MGI:4821070 NCBI chrNW_004955453:4,352,278...4,367,807
Ensembl chrNW_004955453:4,351,668...4,367,807
JBrowse link
G Pld2 phospholipase D2 acts_upstream_of_or_within ISO (MGI:3042801|PMID:14718562) MGI PMID:14718562 MGI:3042801 NCBI chrNW_004955467:10,239,177...10,250,516
Ensembl chrNW_004955467:10,239,177...10,250,890
JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2b calcium/calmodulin dependent protein kinase II beta acts_upstream_of_or_within ISO (MGI:4352609|PMID:19332541) MGI PMID:19332541 MGI:4352609 NCBI chrNW_004955456:7,711,583...7,760,506
Ensembl chrNW_004955456:7,713,552...7,760,207
JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Necab2 N-terminal EF-hand calcium binding protein 2 involved_in ISO (PMID:17689978) UniProt PMID:17689978 NCBI chrNW_004955564:257,781...279,937
Ensembl chrNW_004955564:258,222...277,889
JBrowse link
G Ubqln2 ubiquilin 2 involved_in ISO (PMID:18199683) UniProt PMID:18199683 NCBI chrNW_004955475:3,260,209...3,263,586
Ensembl chrNW_004955475:3,260,503...3,262,380
JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apela apelin receptor early endogenous ligand involved_in ISO (PMID:25639753) UniProt PMID:25639753 NCBI chrNW_004955403:40,257,467...40,266,275 JBrowse link
G Apln apelin involved_in ISO (PMID:11359874)
(MGI:5902690|PMID:11359874)
UniProt PMID:11359874 MGI:5902690 RGD:12907555 NCBI chrNW_004955473:5,346,822...5,356,359
Ensembl chrNW_004955473:5,346,747...5,356,359
JBrowse link
G App amyloid beta precursor protein involved_in ISO (PMID:18723082) ARUK-UCL PMID:18723082 NCBI chrNW_004955407:25,725,259...25,973,582
Ensembl chrNW_004955407:25,722,849...25,974,268
JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplnr apelin receptor involved_in ISO (PMID:25639753) UniProt PMID:25639753 NCBI chrNW_004955511:2,321,445...2,324,417
Ensembl chrNW_004955511:2,322,920...2,324,068
JBrowse link
G Ptger3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chrNW_004955423:21,096,926...21,164,435 JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chrNW_004955423:21,096,926...21,164,435 JBrowse link

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