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ONTOLOGY REPORT - ANNOTATIONS


Term:negative adaptation of signaling pathway
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Accession:GO:0022401 term browser browse the term
Definition:The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.
Synonyms:exact_synonym: negative adaptation of signal transduction pathway;   negative adaptation of signalling pathway



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negative adaptation of signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Entrep1 endosomal transmembrane epsin interactor 1 involved_in ISO (PMID:34927784) RGD PMID:34927784 NCBI chr 1:231,018,987...231,073,474
Ensembl chr 1:221,592,503...221,646,758
JBrowse link
desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin, beta 2 involved_in ISO (PMID:12582207) RGD PMID:12582207 NCBI chr10:55,645,539...55,653,485
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Gipr gastric inhibitory polypeptide receptor IDA RGD PMID:8928774 RGD:2312614 NCBI chr 1:78,804,287...78,814,462
Ensembl chr 1:78,805,593...78,814,462
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 acts_upstream_of_or_within
involved_in
IMP
ISO
IBA
IEA
IDA
MGI:2180127|MGI:87937 (PMID:10338466), (PMID:7761854)
GO_REF:0000033
GO_REF:0000107
(PMID:15102938)
PMID:18223549
RGD
GO_Central
Ensembl
PMID:7761854 PMID:10338466 PMID:15102938 PMID:17908240 PMID:18223549 More... GO_REF:0000033 GO_REF:0000107, RGD:7242040, RGD:8553863, RGD:13792694 NCBI chr 1:211,010,259...211,031,013
Ensembl chr 1:201,581,480...201,601,582
JBrowse link
G Grk3 G protein-coupled receptor kinase 3 involved_in IDA
IBA
IMP
GO_REF:0000033 GO_Central
RGD
PMID:20837135 PMID:8381966 GO_REF:0000033, RGD:5685022, RGD:5685621 NCBI chr12:49,285,228...49,395,803
Ensembl chr12:43,624,897...43,731,262
JBrowse link
G Grk4 G protein-coupled receptor kinase 4 IMP RGD PMID:15166006 RGD:1598508 NCBI chr14:75,998,554...76,080,808
Ensembl chr14:76,006,218...76,080,693
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 IMP RGD PMID:8626574 PMID:30075183 RGD:61618, RGD:13792694 NCBI chr 1:270,014,314...270,208,294
Ensembl chr 1:260,028,242...260,218,701
JBrowse link
G Grk6 G protein-coupled receptor kinase 6 IDA
IMP
RGD PMID:12810562 PMID:17908240 RGD:1299124, RGD:7242040 NCBI chr17:9,182,160...9,198,380
Ensembl chr17:9,177,019...9,192,644
JBrowse link
G Grm5 glutamate metabotropic receptor 5 involved_in IDA PMID:12514208 UniProt PMID:12514208 RGD:728711 NCBI chr 1:150,722,711...151,297,585
Ensembl chr 1:141,312,368...141,882,274
JBrowse link
G Ly6g6e lymphocyte antigen 6 family member G6E involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
(PMID:26276394)
GO_Central
RGD
PMID:26276394 GO_REF:0000033 NCBI chr20:3,744,999...3,749,867
Ensembl chr20:3,744,999...3,750,849
JBrowse link
G Ptger3 prostaglandin E receptor 3 IMP RGD PMID:9350980 RGD:9850278 NCBI chr 2:249,264,985...249,409,966
Ensembl chr 2:246,606,183...246,684,434
JBrowse link
G test test1 TAS
IC
RGD PMID:1403099 PMID:1403099 RGD:632163, RGD:632163
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin involved_in ISO (PMID:10882736) RGD PMID:10882736 NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Arrb1 arrestin, beta 1 involved_in ISO
IBA
(PMID:10521508), (PMID:12582207)
GO_REF:0000033
RGD
GO_Central
PMID:10521508 PMID:12582207 GO_REF:0000033 NCBI chr 1:163,249,654...163,321,711
Ensembl chr 1:153,838,078...153,904,061
JBrowse link
G Arrb2 arrestin, beta 2 involved_in ISO
IBA
IEA
(PMID:10644702), (PMID:12582207)
GO_REF:0000033
GO_REF:0000107
RGD
GO_Central
Ensembl
PMID:10644702 PMID:12582207 GO_REF:0000033 GO_REF:0000107 NCBI chr10:55,645,539...55,653,485
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Calca calcitonin-related polypeptide alpha involved_in ISO (PMID:10882736) RGD PMID:10882736 NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Dnm1 dynamin 1 IMP RGD PMID:14709338 RGD:9685157 NCBI chr 3:36,002,535...36,055,220
Ensembl chr 3:15,604,784...15,648,538
JBrowse link
G Dnm2 dynamin 2 IMP RGD PMID:14709338 RGD:9685157 NCBI chr 8:28,254,344...28,336,297
Ensembl chr 8:19,978,400...20,060,157
JBrowse link
G Drd2 dopamine receptor D2 IDA RGD PMID:14617818 RGD:1581465 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Drd3 dopamine receptor D3 involved_in IDA
IEA
ISO
GO_REF:0000107
(PMID:18424554)
Ensembl
RGD
PMID:18424554 PMID:14617818 GO_REF:0000107, RGD:1581465 NCBI chr11:70,385,586...70,437,793
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G ENSRNOG00000063241 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr13:26,511,609...26,513,494 JBrowse link
G Grk4 G protein-coupled receptor kinase 4 IMP RGD PMID:12519791 RGD:1304268 NCBI chr14:75,998,554...76,080,808
Ensembl chr14:76,006,218...76,080,693
JBrowse link
G Gtf2h2 general transcription factor IIH subunit 2 involved_in ISO (PMID:15775968) RGD PMID:15775968 NCBI chr 2:31,623,752...31,652,697
Ensembl chr 2:31,624,678...31,652,592
JBrowse link
G Pld2 phospholipase D2 acts_upstream_of_or_within ISO (PMID:14718562) RGD PMID:14718562 NCBI chr10:55,754,957...55,772,819
Ensembl chr10:55,256,359...55,272,808
JBrowse link
G Sag S-antigen visual arrestin involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:88,467,797...88,508,821
Ensembl chr 9:88,469,376...88,508,820
JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2b calcium/calmodulin-dependent protein kinase II beta acts_upstream_of_or_within ISO (PMID:19332541) RGD PMID:19332541 NCBI chr14:85,059,166...85,148,121
Ensembl chr14:80,845,238...80,933,994
JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Necab2 N-terminal EF-hand calcium binding protein 2 involved_in ISO
IEA
(PMID:17689978)
GO_REF:0000107
RGD
Ensembl
PMID:17689978 GO_REF:0000107 NCBI chr19:47,501,351...47,527,722
Ensembl chr19:47,501,302...47,527,684
JBrowse link
G Ubqln2 ubiquilin 2 involved_in ISO (PMID:18199683) RGD PMID:18199683 NCBI chr  X:21,228,809...21,232,228
Ensembl chr  X:17,853,114...17,856,505
JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apela apelin receptor early endogenous ligand involved_in ISO (PMID:25639753) RGD PMID:25639753 NCBI chr16:24,694,356...24,703,466
Ensembl chr16:24,694,324...24,703,465
JBrowse link
G Apln apelin involved_in ISO
IDA
(PMID:11359874) RGD PMID:11359874 PMID:11359874 RGD:12907555 NCBI chr  X:132,058,739...132,091,518
Ensembl chr  X:127,203,823...127,213,391
JBrowse link
G Aplnr apelin receptor involved_in ISO (PMID:25639753) RGD PMID:25639753 NCBI chr 3:90,624,055...90,627,700
Ensembl chr 3:70,217,385...70,221,050
JBrowse link
G App amyloid beta precursor protein involved_in ISO (PMID:18723082) RGD PMID:18723082 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561
JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger3 prostaglandin E receptor 3 IMP RGD PMID:15937517 RGD:10043344 NCBI chr 2:249,264,985...249,409,966
Ensembl chr 2:246,606,183...246,684,434
JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger3 prostaglandin E receptor 3 IMP RGD PMID:15937517 RGD:10043344 NCBI chr 2:249,264,985...249,409,966
Ensembl chr 2:246,606,183...246,684,434
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20553
    cellular process 19543
      signal transduction 7262
        negative regulation of signal transduction 1502
          negative adaptation of signaling pathway 30
            adaptation to pheromone regulating conjugation with mutual genetic exchange 0
            desensitization of G protein-coupled receptor signaling pathway + 29
            negative adaptation of signaling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation 0
Path 2
Term Annotations click to browse term
  biological_process 20553
    biological regulation 13833
      regulation of biological process 13387
        signaling 7822
          signal transduction 7262
            regulation of signal transduction 3281
              adaptation of signaling pathway 30
                negative adaptation of signaling pathway 30
                  adaptation to pheromone regulating conjugation with mutual genetic exchange 0
                  desensitization of G protein-coupled receptor signaling pathway + 29
                  negative adaptation of signaling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation 0
paths to the root