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ONTOLOGY REPORT - ANNOTATIONS


Term:smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
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Accession:GO:0021776 term browser browse the term
Definition:The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the spinal cord that contributes to the process of a precursor cell becoming capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway.
Synonyms:exact_synonym: hedgehog signaling pathway involved in spinal cord motor neuron cell fate specification;   hh signaling pathway involved in spinal cord motor neuron cell fate specification;   smoothened signalling pathway involved in spinal cord motor neuron cell fate specification



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smoothened signaling pathway involved in spinal cord motor neuron cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli2 GLI-Kruppel family member GLI2 acts_upstream_of_or_within IGI (MGI:3051712|PMID:15215207) MGI PMID:15215207 MGI:3051712 NCBI chr 1:118,761,791...118,987,578
Ensembl chr 1:118,761,862...118,981,349
JBrowse link
G Gli3 GLI-Kruppel family member GLI3 acts_upstream_of_or_within IGI (MGI:3051712|PMID:15215207) MGI PMID:15215207 MGI:3051712 NCBI chr13:15,638,308...15,904,611
Ensembl chr13:15,637,820...15,904,611
JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling acts_upstream_of_or_within IMP (MGI:4355593|PMID:19684112) MGI PMID:19684112 MGI:4355593 NCBI chr19:46,385,335...46,477,243
Ensembl chr19:46,385,335...46,477,243
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28558
    developmental process 7345
      anatomical structure development 6817
        ventral spinal cord development 56
          spinal cord motor neuron differentiation 40
            spinal cord motor neuron cell fate specification 11
              smoothened signaling pathway involved in spinal cord motor neuron cell fate specification 3
Path 2
Term Annotations click to browse term
  biological_process 28558
    developmental process 7345
      anatomical structure development 6817
        multicellular organism development 5407
          system development 4631
            nervous system development 2822
              neurogenesis 2095
                generation of neurons 1812
                  neuron differentiation 1728
                    central nervous system neuron differentiation 221
                      spinal cord motor neuron differentiation 40
                        spinal cord motor neuron cell fate specification 11
                          smoothened signaling pathway involved in spinal cord motor neuron cell fate specification 3
paths to the root