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ONTOLOGY REPORT - ANNOTATIONS

Term:smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
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Accession:GO:0021776 term browser browse the term
Definition:The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the spinal cord that contributes to the process of a precursor cell becoming capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway.
Synonyms:exact_synonym: hedgehog signaling pathway involved in spinal cord motor neuron cell fate specification;   hh signaling pathway involved in spinal cord motor neuron cell fate specification;   smoothened signalling pathway involved in spinal cord motor neuron cell fate specification


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smoothened signaling pathway involved in spinal cord motor neuron cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLI2 GLI family zinc finger 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15215207) Ensembl
MGI		 PMID:15215207 GO_REF:0000107 NCBI chr2B:7,665,403...7,922,840
Ensembl chr2B:121,303,831...121,497,442 		JBrowse link
G GLI3 GLI family zinc finger 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15215207) Ensembl
MGI		 PMID:15215207 GO_REF:0000107 NCBI chr 7:42,004,965...42,280,772
Ensembl chr 7:42,056,565...42,322,865 		JBrowse link
G SUFU SUFU negative regulator of hedgehog signaling involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19684112) Ensembl
MGI		 PMID:19684112 GO_REF:0000107 NCBI chr10:99,107,516...99,231,761
Ensembl chr10:102,571,886...102,696,472 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16440
    developmental process 6563
      anatomical structure development 6172
        ventral spinal cord development 50
          spinal cord motor neuron differentiation 34
            spinal cord motor neuron cell fate specification 11
              smoothened signaling pathway involved in spinal cord motor neuron cell fate specification 3
Path 2
Term Annotations click to browse term
  biological_process 16440
    developmental process 6563
      anatomical structure development 6172
        multicellular organism development 4975
          system development 4324
            nervous system development 2702
              neurogenesis 2004
                generation of neurons 1729
                  neuron differentiation 1646
                    central nervous system neuron differentiation 214
                      spinal cord motor neuron differentiation 34
                        spinal cord motor neuron cell fate specification 11
                          smoothened signaling pathway involved in spinal cord motor neuron cell fate specification 3
paths to the root