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ONTOLOGY REPORT - ANNOTATIONS


Term:cerebellar Purkinje cell layer morphogenesis
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Accession:GO:0021692 term browser browse the term
Definition:The process in which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.



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cerebellar Purkinje cell layer morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 acts_upstream_of_or_within ISO MGI:1857876 (MGI:3709537|PMID:17409239) RGD PMID:17409239 MGI:3709537 NCBI chr 4:146,896,332...147,140,665
Ensembl chr 4:146,896,332...147,140,665
JBrowse link
G Cntnap2 contactin associated protein 2 involved_in ISO (MGI:6477849|PMID:32675284) RGD PMID:32675284 MGI:6477849 NCBI chr 4:74,109,455...76,366,434
Ensembl chr 4:74,109,472...76,362,027
JBrowse link
G Coq8b coenzyme Q8B involved_in ISS
ISO
GO_REF:0000024
(PMID:27499294)
UniProt
RGD
PMID:27499294 GO_REF:0000024 NCBI chr 1:82,525,578...82,549,182
Ensembl chr 1:82,526,568...82,549,180
JBrowse link
G Sptbn2 spectrin, beta, non-erythrocytic 2 acts_upstream_of_or_within ISO MGI:4127354 (MGI:4438955|PMID:20231455) RGD PMID:20231455 MGI:4438955 NCBI chr 1:202,002,970...202,045,343
Ensembl chr 1:202,002,970...202,044,283
JBrowse link
cerebellar Purkinje cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtpbp1 ATP/GTP binding carboxypeptidase 1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr17:5,120,540...5,238,874
Ensembl chr17:5,120,609...5,238,869
JBrowse link
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 acts_upstream_of_or_within ISO MGI:1857876 (MGI:1275896|PMID:9668038) RGD PMID:9668038 MGI:1275896 NCBI chr 4:146,896,332...147,140,665
Ensembl chr 4:146,896,332...147,140,665
JBrowse link
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within ISO MGI:1856466 (MGI:71790|PMID:2473662) RGD PMID:2473662 MGI:71790 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354
JBrowse link
G Atxn2 ataxin 2 acts_upstream_of_or_within ISO MGI:3505741 (MGI:3510013|PMID:10973246) RGD PMID:10973246 MGI:3510013 NCBI chr12:34,754,132...34,851,175
Ensembl chr12:34,754,137...34,851,479
JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO MGI:1856209|MGI:1856210 (MGI:1347769|PMID:10630211), (MGI:62667|PMID:1306163), (MGI:68980|PMID:7834360) RGD PMID:1306163 PMID:7834360 PMID:10630211 MGI:1347769 MGI:62667 MGI:68980 NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225
JBrowse link
G Cend1 cell cycle exit and neuronal differentiation 1 acts_upstream_of_or_within
involved_in
ISO
IBA
MGI:4831137 (MGI:4830814|PMID:20153830)
PMID:21873635
RGD PMID:20153830 PMID:21873635 MGI:4830814, RGD:13792537 NCBI chr 1:196,525,153...196,528,152
Ensembl chr 1:196,523,920...196,528,302
JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:5295128|PMID:21957071)
UniProt
Ensembl
RGD
PMID:21957071 GO_REF:0000024 GO_REF:0000107 MGI:5295128 NCBI chr 7:130,632,368...130,659,353
Ensembl chr 7:130,633,348...130,659,168
JBrowse link
G Foxp2 forkhead box P2 involved_in ISO MGI:3778383 (MGI:5306536|PMID:22133810) RGD PMID:22133810 MGI:5306536 NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683
JBrowse link
G Herc1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 acts_upstream_of_or_within ISO MGI:3613033 (MGI:4461108|PMID:20041218) RGD PMID:20041218 MGI:4461108 NCBI chr 8:66,857,169...67,070,318
Ensembl chr 8:66,856,935...67,070,312
JBrowse link
G Ldb1 LIM domain binding 1 acts_upstream_of_or_within ISO MGI:3719683 (MGI:3718715|PMID:17664423) RGD PMID:17664423 MGI:3718715 NCBI chr 1:244,864,168...244,890,007
Ensembl chr 1:244,877,173...244,890,013
JBrowse link
G Lhx1 LIM homeobox 1 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
MGI:107792 (MGI:3718715|PMID:17664423)
UniProt
RGD
PMID:17664423 GO_REF:0000024 MGI:3718715 NCBI chr10:69,396,829...69,403,617
Ensembl chr10:69,396,829...69,403,617
JBrowse link
G Lhx5 LIM homeobox 5 acts_upstream_of_or_within ISO MGI:99783 (MGI:3718715|PMID:17664423) RGD PMID:17664423 MGI:3718715 NCBI chr12:36,126,186...36,134,625
Ensembl chr12:36,126,186...36,134,625
JBrowse link
G Psap prosaposin acts_upstream_of_or_within ISO MGI:3521746 (MGI:3512714|PMID:15345707) RGD PMID:15345707 MGI:3512714 NCBI chr20:28,214,229...28,240,501
Ensembl chr20:28,214,271...28,240,498
JBrowse link
G Rora RAR-related orphan receptor A acts_upstream_of_or_within ISO MGI:1857035 (MGI:86446|PMID:8996814) RGD PMID:8996814 MGI:86446 NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931
JBrowse link
G Skor2 SKI family transcriptional corepressor 2 acts_upstream_of_or_within ISO MGI:5300464 (MGI:5300220|PMID:21937600), (MGI:5565016|PMID:24491816) RGD PMID:21937600 PMID:24491816 MGI:5300220 MGI:5565016 NCBI chr18:70,404,431...70,446,330
Ensembl chr18:70,404,489...70,440,342
JBrowse link
G Slc25a46 solute carrier family 25, member 46 acts_upstream_of_or_within ISO MGI:6358090 (MGI:5921109|PMID:28934388) RGD PMID:28934388 MGI:5921109 NCBI chr18:23,215,954...23,244,917
Ensembl chr18:23,215,962...23,244,314
JBrowse link
G Top2a DNA topoisomerase II alpha IEP RGD PMID:11170002 RGD:8693630 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Ttc21b tetratricopeptide repeat domain 21B acts_upstream_of_or_within ISO MGI:2137515|MGI:2152544|MGI:2179048|MGI:5587034 (MGI:6152587|PMID:29615573) RGD PMID:29615573 MGI:6152587 NCBI chr 3:50,861,367...50,935,782
Ensembl chr 3:50,861,367...50,935,903
JBrowse link
G Ttll1 TTL family tubulin polyglutamylase complex subunit L1 acts_upstream_of_or_within ISO MGI:1918244 (MGI:6269036|PMID:30420556) RGD PMID:30420556 MGI:6269036 NCBI chr 7:114,619,509...114,648,850
Ensembl chr 7:114,619,508...114,648,761
JBrowse link
cerebellar Purkinje cell layer formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gba glucosylceramidase beta acts_upstream_of_or_within ISO (MGI:3762988|PMID:17954912) RGD PMID:17954912 MGI:3762988 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263
JBrowse link
G Whrn whirlin involved_in IEA
ISO
GO_REF:0000107
(MGI:5516521|PMID:24011083)
Ensembl
RGD
PMID:24011083 GO_REF:0000107 MGI:5516521 NCBI chr 5:76,828,308...76,911,945
Ensembl chr 5:76,828,301...76,912,223
JBrowse link
cerebellar Purkinje cell layer structural organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll1 delta like canonical Notch ligand 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:5504540|PMID:23688253)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:23688253 GO_REF:0000024 GO_REF:0000107 MGI:5504540 NCBI chr 1:56,312,062...56,320,177
Ensembl chr 1:56,312,066...56,320,179
JBrowse link
G Kif14 kinesin family member 14 involved_in ISO (MGI:5485315|PMID:23308235) RGD PMID:23308235 MGI:5485315 NCBI chr13:47,926,975...47,990,598
Ensembl chr13:47,927,044...47,989,164
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18734
    developmental process 6893
      anatomical structure morphogenesis 2987
        cerebellar Purkinje cell layer morphogenesis 26
          cerebellar Purkinje cell layer formation + 21
          cerebellar Purkinje cell layer structural organization 2
Path 2
Term Annotations click to browse term
  biological_process 18734
    developmental process 6893
      anatomical structure development 6368
        multicellular organism development 5437
          system development 4939
            nervous system development 2767
              central nervous system development 1292
                brain development 990
                  hindbrain development 223
                    metencephalon development 169
                      cerebellum development 155
                        cerebellar cortex development 70
                          cerebellar Purkinje cell layer development 40
                            cerebellar Purkinje cell layer morphogenesis 26
                              cerebellar Purkinje cell layer formation + 21
                              cerebellar Purkinje cell layer structural organization 2
paths to the root