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ONTOLOGY REPORT - ANNOTATIONS

Term:cerebellar Purkinje cell layer development
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Accession:GO:0021680 term browser browse the term
Definition:The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.


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cerebellar Purkinje cell layer development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AARS1 alanyl-tRNA synthetase 1 acts_upstream_of_or_within ISO (PMID:16906134) MGI PMID:16906134 NCBI chr16:54,727,601...54,763,458
Ensembl chr16:70,086,735...70,121,902 		JBrowse link
G ATG7 autophagy related 7 acts_upstream_of_or_within ISO (PMID:16625205)
(PMID:20577052)		 MGI PMID:16625205 PMID:20577052 NCBI chr 3:11,208,600...11,488,757
Ensembl chr 3:11,554,100...11,833,398 		JBrowse link
G B4GALT2 beta-1,4-galactosyltransferase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19265195) Ensembl
MGI		 PMID:19265195 GO_REF:0000107 NCBI chr 1:43,281,011...43,292,992
Ensembl chr 1:44,652,906...44,664,401 		JBrowse link
G CACNA1A calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO (PMID:1306163) MGI PMID:1306163 NCBI chr19:12,769,586...13,189,022
Ensembl chr19:13,507,102...13,804,729 		JBrowse link
G FAIM2 Fas apoptotic inhibitory molecule 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:38,850,588...38,886,614
Ensembl chr12:39,744,700...39,780,702 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 involved_in ISO (MGI:4437543|PMID:19816510) BHF-UCL PMID:19816510 MGI:4437543 NCBI chr 9:96,351,645...96,356,761
Ensembl chr 9:124,865,211...124,870,458 		JBrowse link
G KLHL1 kelch like family member 1 acts_upstream_of_or_within ISO (PMID:17005861) MGI PMID:17005861 NCBI chr13:50,906,581...51,335,692
Ensembl chr13:69,691,537...70,118,448 		JBrowse link
G LOC100987427 cytochrome b-c1 complex subunit 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:128,283,869...128,285,010
Ensembl chr 5:134,442,883...134,444,020 		JBrowse link
G MYH10 myosin heavy chain 10 acts_upstream_of_or_within ISO (PMID:16481398) MGI PMID:16481398 NCBI chr17:43,023,922...43,180,159
Ensembl chr17:47,761,322...47,911,192 		JBrowse link
G NAGLU N-acetyl-alpha-glucosaminidase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17712420) Ensembl
MGI		 PMID:17712420 GO_REF:0000107 NCBI chr17:14,772,054...14,780,398
Ensembl chr17:14,996,420...15,004,242 		JBrowse link
G NFIX nuclear factor I X acts_upstream_of_or_within ISO (PMID:21800304) MGI PMID:21800304 NCBI chr19:12,557,020...12,660,316
Ensembl chr19:13,327,690...13,402,406 		JBrowse link
G SEZ6 seizure related 6 homolog involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16814779) Ensembl
MGI		 PMID:16814779 GO_REF:0000107 NCBI chr17:27,768,229...27,819,257
Ensembl chr17:28,301,359...28,327,354 		JBrowse link
G SEZ6L seizure related 6 homolog like acts_upstream_of_or_within ISO (PMID:16814779) MGI PMID:16814779 NCBI chr22:7,230,597...7,445,397
Ensembl chr22:25,077,259...25,163,881 		JBrowse link
G SEZ6L2 seizure related 6 homolog like 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16814779) Ensembl
MGI		 PMID:16814779 GO_REF:0000107 Ensembl chr16:30,240,276...30,267,689 JBrowse link
cerebellar Purkinje cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2B2 ATPase plasma membrane Ca2+ transporting 2 acts_upstream_of_or_within ISO (PMID:9668038) MGI PMID:9668038 NCBI chr 3:10,260,556...10,643,346
Ensembl chr 3:10,611,619...10,738,006 		JBrowse link
G ATP7A ATPase copper transporting alpha acts_upstream_of_or_within ISO (PMID:2473662) MGI PMID:2473662 NCBI chr  X:67,093,675...67,231,318
Ensembl chr  X:77,255,312...77,342,756 		JBrowse link
G ATXN2 ataxin 2 acts_upstream_of_or_within ISO (PMID:10973246) MGI PMID:10973246 NCBI chr12:109,024,620...109,174,135
Ensembl chr12:112,419,337...112,566,360 		JBrowse link
G CACNA1A calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO (PMID:1306163)
(PMID:7834360)
(PMID:10630211)		 MGI PMID:1306163 PMID:7834360 PMID:10630211 NCBI chr19:12,769,586...13,189,022
Ensembl chr19:13,507,102...13,804,729 		JBrowse link
G CEND1 cell cycle exit and neuronal differentiation 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20153830) TreeGrafter
MGI		 PMID:20153830 GO_REF:0000118 NCBI chr11:804,517...807,608
Ensembl chr11:849,678...850,127 		JBrowse link
G FAIM2 Fas apoptotic inhibitory molecule 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:38,850,588...38,886,614
Ensembl chr12:39,744,700...39,780,702 		JBrowse link
G FOXP2 forkhead box P2 involved_in ISO (PMID:22133810) MGI PMID:22133810 NCBI chr 7:106,040,118...106,648,741
Ensembl chr 7:119,077,332...119,343,893 		JBrowse link
G HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20041218) Ensembl
MGI		 PMID:20041218 GO_REF:0000107 NCBI chr15:42,555,131...42,785,228
Ensembl chr15:60,848,493...61,017,244 		JBrowse link
G LDB1 LIM domain binding 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17664423) Ensembl
MGI		 PMID:17664423 GO_REF:0000107 NCBI chr10:98,707,470...98,722,771
Ensembl chr10:102,179,757...102,184,047 		JBrowse link
G LHX1 LIM homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17664423) Ensembl
MGI		 PMID:17664423 GO_REF:0000107 NCBI chr17:20,134,308...20,140,652
Ensembl chr17:20,430,618...20,437,751 		JBrowse link
G LHX5 LIM homeobox 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17664423) Ensembl
MGI		 PMID:17664423 GO_REF:0000107 NCBI chr12:111,063,466...111,075,445
Ensembl chr12:114,445,766...114,454,960 		JBrowse link
G PSAP prosaposin acts_upstream_of_or_within ISO (PMID:15345707) MGI PMID:15345707 NCBI chr10:68,286,359...68,321,349
Ensembl chr10:70,810,881...70,828,781 		JBrowse link
G RORA RAR related orphan receptor A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:8996814) Ensembl
MGI		 PMID:8996814 GO_REF:0000107 NCBI chr15:39,461,553...40,200,118
Ensembl chr15:57,771,735...57,980,460 		JBrowse link
G SKOR2 SKI family transcriptional corepressor 2 acts_upstream_of_or_within ISO (PMID:24491816)
(PMID:21937600)		 MGI PMID:21937600 PMID:24491816 NCBI chr18:40,594,124...40,639,720 JBrowse link
G SLC25A46 solute carrier family 25 member 46 acts_upstream_of_or_within ISO (PMID:28934388) MGI PMID:28934388 NCBI chr 5:106,106,112...106,132,355
Ensembl chr 5:111,908,842...111,935,029 		JBrowse link
G TOP2A DNA topoisomerase II alpha ISO RGD PMID:11170002 RGD:8693630 NCBI chr17:16,872,169...16,901,605
Ensembl chr17:17,097,778...17,126,207 		JBrowse link
G TTC21B tetratricopeptide repeat domain 21B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:29615573) Ensembl
MGI		 PMID:29615573 GO_REF:0000107 NCBI chr2B:53,140,199...53,220,535
Ensembl chr2B:170,616,444...170,699,471 		JBrowse link
G TTLL1 TTL family tubulin polyglutamylase complex subunit L1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:30420556) Ensembl
MGI		 PMID:30420556 GO_REF:0000107 NCBI chr22:23,924,628...23,973,282
Ensembl chr22:42,128,224...42,174,850 		JBrowse link
cerebellar Purkinje cell layer formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GBA1 glucosylceramidase beta 1 acts_upstream_of_or_within ISO (PMID:17954912) MGI PMID:17954912 NCBI chr 1:130,579,300...130,589,560
Ensembl chr 1:134,185,385...134,194,851 		JBrowse link
G WHRN whirlin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:85,500,222...85,604,417
Ensembl chr 9:113,863,872...113,966,758 		JBrowse link
cerebellar Purkinje cell layer maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARCN1 archain 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20502676) Ensembl
MGI		 PMID:20502676 GO_REF:0000107 NCBI chr11:113,411,166...113,441,792
Ensembl chr11:117,341,427...117,371,589 		JBrowse link
G RERE arginine-glutamic acid dipeptide repeats involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24466353) Ensembl
MGI		 PMID:24466353 GO_REF:0000107 NCBI chr 1:7,111,594...7,576,667
Ensembl chr 1:8,351,367...8,648,973 		JBrowse link
cerebellar Purkinje cell layer morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2B2 ATPase plasma membrane Ca2+ transporting 2 acts_upstream_of_or_within ISO (PMID:17409239) MGI PMID:17409239 NCBI chr 3:10,260,556...10,643,346
Ensembl chr 3:10,611,619...10,738,006 		JBrowse link
G CNTNAP2 contactin associated protein 2 involved_in ISO (PMID:32675284) MGI PMID:32675284 NCBI chr 7:137,858,607...140,150,820
Ensembl chr 7:150,345,240...152,626,818 		JBrowse link
G COQ8B coenzyme Q8B involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:37,735,725...37,761,160
Ensembl chr19:46,242,576...46,267,503 		JBrowse link
G SPTBN2 spectrin beta, non-erythrocytic 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20231455) Ensembl
MGI		 PMID:20231455 GO_REF:0000107 NCBI chr11:62,042,617...62,086,634
Ensembl chr11:65,365,588...65,409,207 		JBrowse link
cerebellar Purkinje cell layer structural organization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DLL1 delta like canonical Notch ligand 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:168,440,192...168,449,071
Ensembl chr 6:173,534,292...173,544,759 		JBrowse link
G KIF14 kinesin family member 14 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:176,156,870...176,223,093
Ensembl chr 1:180,462,578...180,526,323 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16440
    developmental process 6563
      anatomical structure development 6172
        cerebellar Purkinje cell layer development 39
          cerebellar Purkinje cell layer maturation 2
          cerebellar Purkinje cell layer morphogenesis + 25
Path 2
Term Annotations click to browse term
  biological_process 16440
    developmental process 6563
      anatomical structure development 6172
        multicellular organism development 4975
          system development 4324
            nervous system development 2702
              central nervous system development 1165
                brain development 881
                  hindbrain development 223
                    metencephalon development 170
                      cerebellum development 156
                        cerebellar cortex development 70
                          cerebellar Purkinje cell layer development 39
                            cerebellar Purkinje cell layer maturation 2
                            cerebellar Purkinje cell layer morphogenesis + 25
paths to the root