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ONTOLOGY REPORT - ANNOTATIONS

Term:spinal cord motor neuron differentiation
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Accession:GO:0021522 term browser browse the term
Definition:The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.


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spinal cord motor neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABT1 activator of basal transcription 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19299493) Ensembl
MGI		 PMID:19299493 GO_REF:0000107 NCBI chr 6:26,596,953...26,600,739
Ensembl chr 6:26,596,953...26,600,739 		JBrowse link
G CACNA1A calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO (PMID:17156092) MGI PMID:17156092 NCBI chr19:13,206,442...13,506,479
Ensembl chr19:13,206,442...13,633,025 		JBrowse link
G CLN8 CLN8 transmembrane ER and ERGIC protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:2061715) Ensembl
MGI		 PMID:2061715 GO_REF:0000107 NCBI chr 8:1,753,059...1,786,570
Ensembl chr 8:1,755,778...1,801,711 		JBrowse link
G DICER1 dicer 1, ribonuclease III acts_upstream_of_or_within ISO (PMID:21338882) MGI PMID:21338882 NCBI chr14:95,086,228...95,158,010
Ensembl chr14:95,086,228...95,158,010 		JBrowse link
G DYNC2H1 dynein cytoplasmic 2 heavy chain 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21552265) Ensembl
MGI		 PMID:21552265 GO_REF:0000107 NCBI chr11:103,109,426...103,479,863
Ensembl chr11:103,109,410...103,479,863 		JBrowse link
G GBX1 gastrulation brain homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23418536) Ensembl
MGI		 PMID:23418536 GO_REF:0000107 NCBI chr 7:151,148,009...151,167,694
Ensembl chr 7:151,148,009...151,174,745 		JBrowse link
G GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 acts_upstream_of_or_within ISO (PMID:21943603) MGI PMID:21943603 NCBI chr11:75,434,640...75,525,941
Ensembl chr11:75,434,640...75,525,941 		JBrowse link
G GIGYF2 GRB10 interacting GYF protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19744960) Ensembl
MGI		 PMID:19744960 GO_REF:0000107 NCBI chr 2:232,697,331...232,860,605
Ensembl chr 2:232,697,299...232,860,605 		JBrowse link
G GLI2 GLI family zinc finger 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21552265) Ensembl
MGI		 PMID:21552265 GO_REF:0000107 NCBI chr 2:120,735,868...120,992,653
Ensembl chr 2:120,735,623...120,992,653 		JBrowse link
G GLI3 GLI family zinc finger 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21552265) Ensembl
MGI		 PMID:21552265 GO_REF:0000107 NCBI chr 7:41,960,949...42,264,268
Ensembl chr 7:41,960,949...42,264,100 		JBrowse link
G IFT172 intraflagellar transport 172 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21552265) Ensembl
MGI		 PMID:21552265 GO_REF:0000107 NCBI chr 2:27,444,377...27,489,743
Ensembl chr 2:27,444,377...27,489,805 		JBrowse link
G IGHMBP2 immunoglobulin mu DNA binding protein 2 acts_upstream_of_or_within ISO (PMID:19299493) MGI PMID:19299493 NCBI chr11:68,903,891...68,940,601
Ensembl chr11:68,903,863...68,940,602 		JBrowse link
G ISL1 ISL LIM homeobox 1 involved_in
acts_upstream_of_or_within		 ISS
ISO
IEA		 (PMID:8565076) BHF-UCL
MGI
Ensembl		 PMID:8565076 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:51,383,448...51,394,730
Ensembl chr 5:51,383,448...51,394,730 		JBrowse link
G LBX1 ladybird homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15769945) Ensembl
MGI		 PMID:15769945 GO_REF:0000107 NCBI chr10:101,226,994...101,229,463
Ensembl chr10:101,226,994...101,229,463 		JBrowse link
G LMO4 LIM domain only 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19666821) Ensembl
MGI		 PMID:19666821 GO_REF:0000107 NCBI chr 1:87,328,880...87,348,923
Ensembl chr 1:87,328,880...87,348,923 		JBrowse link
G MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 involved_in ISS (PMID:15019943) HGNC-UCL PMID:15019943 NCBI chr14:46,839,623...47,675,605
Ensembl chr14:46,840,092...47,675,605 		JBrowse link
G MIR17 microRNA 17 acts_upstream_of_or_within ISO (PMID:21338882) MGI PMID:21338882 NCBI chr13:91,350,605...91,350,688
Ensembl chr13:91,350,605...91,350,688 		JBrowse link
G MIR18A microRNA 18a acts_upstream_of_or_within ISO (PMID:21338882) MGI PMID:21338882 NCBI chr13:91,350,751...91,350,821
Ensembl chr13:91,350,751...91,350,821 		JBrowse link
G MIR19A microRNA 19a acts_upstream_of_or_within ISO (PMID:21338882) MGI PMID:21338882 NCBI chr13:91,350,891...91,350,972
Ensembl chr13:91,350,891...91,350,972 		JBrowse link
G MIR19B1 microRNA 19b-1 acts_upstream_of_or_within ISO (PMID:21741442) MGI PMID:21741442 NCBI chr13:91,351,192...91,351,278
Ensembl chr13:91,351,192...91,351,278 		JBrowse link
G MIR20A microRNA 20a acts_upstream_of_or_within ISO (PMID:21338882) MGI PMID:21338882 NCBI chr13:91,351,065...91,351,135
Ensembl chr13:91,351,065...91,351,135 		JBrowse link
G MIR92A1 microRNA 92a-1 acts_upstream_of_or_within ISO (PMID:21338882) MGI PMID:21338882 NCBI chr13:91,351,314...91,351,391
Ensembl chr13:91,351,314...91,351,391 		JBrowse link
G NFE2L1 NFE2 like bZIP transcription factor 1 acts_upstream_of_or_within ISO (PMID:21554501) MGI PMID:21554501 NCBI chr17:48,048,359...48,061,545
Ensembl chr17:48,048,329...48,061,545 		JBrowse link
G NKX2-2 NK2 homeobox 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10217145) Ensembl
MGI		 PMID:10217145 GO_REF:0000107 NCBI chr20:21,511,017...21,522,689
Ensembl chr20:21,511,017...21,514,064 		JBrowse link
G OLIG2 oligodendrocyte transcription factor 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21338882) Ensembl
MGI		 PMID:21338882 GO_REF:0000107 NCBI chr21:33,025,935...33,029,185
Ensembl chr21:33,025,935...33,029,196 		JBrowse link
G OLIG3 oligodendrocyte transcription factor 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15674731)
(PMID:15769945)		 Ensembl
MGI		 PMID:15674731 PMID:15769945 GO_REF:0000107 NCBI chr 6:137,492,199...137,494,394
Ensembl chr 6:137,492,199...137,494,394 		JBrowse link
G PTCH1 patched 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21552265) Ensembl
MGI		 PMID:21552265 GO_REF:0000107 NCBI chr 9:95,442,980...95,516,971
Ensembl chr 9:95,442,980...95,517,057 		JBrowse link
G SCYL1 SCY1 like pseudokinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:29437892) Ensembl
MGI		 PMID:29437892 GO_REF:0000107 NCBI chr11:65,525,083...65,538,704
Ensembl chr11:65,525,077...65,538,704 		JBrowse link
G SCYL3 SCY1 like pseudokinase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:29437892) Ensembl
MGI		 PMID:29437892 GO_REF:0000107 NCBI chr 1:169,849,631...169,894,268
Ensembl chr 1:169,849,631...169,894,267 		JBrowse link
G SHH sonic hedgehog signaling molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21552265) Ensembl
MGI		 PMID:21552265 GO_REF:0000107 NCBI chr 7:155,799,980...155,812,463
Ensembl chr 7:155,799,980...155,812,463 		JBrowse link
G ZC4H2 zinc finger C4H2-type containing involved_in ISS UniProt GO_REF:0000024 NCBI chr  X:64,915,807...65,034,741
Ensembl chr  X:64,915,802...65,034,713 		JBrowse link
medial motor column neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LHX3 LIM homeobox 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9865699) Ensembl
MGI		 PMID:9865699 GO_REF:0000107 NCBI chr 9:136,196,250...136,205,128
Ensembl chr 9:136,196,250...136,205,128 		JBrowse link
G LHX4 LIM homeobox 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9865699) Ensembl
MGI		 PMID:9865699 GO_REF:0000107 NCBI chr 1:180,228,375...180,278,984
Ensembl chr 1:180,230,264...180,278,984 		JBrowse link
smoothened signaling pathway involved in spinal cord motor neuron cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLI2 GLI family zinc finger 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15215207) Ensembl
MGI		 PMID:15215207 GO_REF:0000107 NCBI chr 2:120,735,868...120,992,653
Ensembl chr 2:120,735,623...120,992,653 		JBrowse link
G GLI3 GLI family zinc finger 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15215207) Ensembl
MGI		 PMID:15215207 GO_REF:0000107 NCBI chr 7:41,960,949...42,264,268
Ensembl chr 7:41,960,949...42,264,100 		JBrowse link
G SUFU SUFU negative regulator of hedgehog signaling involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19684112) Ensembl
MGI		 PMID:19684112 GO_REF:0000107 NCBI chr10:102,502,819...102,633,535
Ensembl chr10:102,503,972...102,633,535 		JBrowse link
somatic motor neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLN8 CLN8 transmembrane ER and ERGIC protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21052544) Ensembl
MGI		 PMID:21052544 GO_REF:0000107 NCBI chr 8:1,753,059...1,786,570
Ensembl chr 8:1,755,778...1,801,711 		JBrowse link
G PHOX2A paired like homeobox 2A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16319924) Ensembl
MGI		 PMID:16319924 GO_REF:0000107 NCBI chr11:72,239,077...72,244,176
Ensembl chr11:72,239,077...72,245,664 		JBrowse link
G TCTN1 tectonic family member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16357211) Ensembl
MGI		 PMID:16357211 GO_REF:0000107 NCBI chr12:110,614,129...110,649,430
Ensembl chr12:110,614,027...110,663,431 		JBrowse link
spinal cord motor neuron cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HOXC10 homeobox C10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18065432) Ensembl
MGI		 PMID:18065432 GO_REF:0000107 NCBI chr12:53,985,146...53,990,279
Ensembl chr12:53,985,065...53,990,279 		JBrowse link
G HOXD10 homeobox D10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18065432) Ensembl
MGI		 PMID:18065432 GO_REF:0000107 NCBI chr 2:176,116,778...176,119,937
Ensembl chr 2:176,108,790...176,119,937 		JBrowse link
G ISL1 ISL LIM homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19666821) Ensembl
MGI		 PMID:19666821 GO_REF:0000107 NCBI chr 5:51,383,448...51,394,730
Ensembl chr 5:51,383,448...51,394,730 		JBrowse link
G ISL2 ISL LIM homeobox 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19666821) Ensembl
MGI		 PMID:19666821 GO_REF:0000107 NCBI chr15:76,336,773...76,342,475
Ensembl chr15:76,336,773...76,342,475 		JBrowse link
G LHX3 LIM homeobox 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19666821) Ensembl
MGI		 PMID:19666821 GO_REF:0000107 NCBI chr 9:136,196,250...136,205,128
Ensembl chr 9:136,196,250...136,205,128 		JBrowse link
G LMO4 LIM domain only 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:87,328,880...87,348,923
Ensembl chr 1:87,328,880...87,348,923 		JBrowse link
G MNX1 motor neuron and pancreas homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:10482234) InterPro
MGI
GO_Central		 PMID:10482234 GO_REF:0000002 GO_REF:0000033 NCBI chr 7:157,004,854...157,010,663
Ensembl chr 7:156,994,051...157,010,663 		JBrowse link
G OLIG3 oligodendrocyte transcription factor 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15769945) Ensembl
MGI		 PMID:15769945 GO_REF:0000107 NCBI chr 6:137,492,199...137,494,394
Ensembl chr 6:137,492,199...137,494,394 		JBrowse link
visceral motor neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ISL1 ISL LIM homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14766174) Ensembl
MGI		 PMID:14766174 GO_REF:0000107 NCBI chr 5:51,383,448...51,394,730
Ensembl chr 5:51,383,448...51,394,730 		JBrowse link
G ISL2 ISL LIM homeobox 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14766174) Ensembl
MGI		 PMID:14766174 GO_REF:0000107 NCBI chr15:76,336,773...76,342,475
Ensembl chr15:76,336,773...76,342,475 		JBrowse link
G TBX20 T-box transcription factor 20 involved_in IEA
ISS		 Ensembl
BHF-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:35,202,430...35,254,100
Ensembl chr 7:35,202,430...35,254,100 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19669
    developmental process 7610
      anatomical structure development 7020
        ventral spinal cord development 58
          spinal cord motor neuron differentiation 41
            lateral motor column neuron differentiation 0
            somatic motor neuron differentiation + 5
            spinal cord motor neuron cell fate specification + 11
            visceral motor neuron differentiation 3
Path 2
Term Annotations click to browse term
  biological_process 19669
    developmental process 7610
      anatomical structure development 7020
        multicellular organism development 5632
          system development 4908
            nervous system development 3048
              neurogenesis 2140
                generation of neurons 1853
                  neuron differentiation 1769
                    central nervous system neuron differentiation 222
                      spinal cord motor neuron differentiation 41
                        lateral motor column neuron differentiation 0
                        somatic motor neuron differentiation + 5
                        spinal cord motor neuron cell fate specification + 11
                        visceral motor neuron differentiation 3
paths to the root