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ONTOLOGY REPORT - ANNOTATIONS

Term:spinal cord motor neuron differentiation
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Accession:GO:0021522 term browser browse the term
Definition:The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.


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spinal cord motor neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABT1 activator of basal transcription 1 acts_upstream_of_or_within ISO (PMID:19299493) MGI PMID:19299493 NCBI chr35:24,357,502...24,360,731
Ensembl chr35:24,357,460...24,359,318 		JBrowse link
G CACNA1A calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO (PMID:17156092) MGI PMID:17156092 NCBI chr20:48,747,087...49,036,627
Ensembl chr20:48,821,025...49,036,032 		JBrowse link
G CLN8 CLN8 transmembrane ER and ERGIC protein acts_upstream_of_or_within ISO (PMID:2061715) MGI PMID:2061715 NCBI chr37:30,863,098...30,885,831
Ensembl chr37:30,867,479...30,884,895 		JBrowse link
G DICER1 dicer 1, ribonuclease III acts_upstream_of_or_within ISO (PMID:21338882) MGI PMID:21338882 NCBI chr 8:63,970,245...64,029,438
Ensembl chr 8:63,972,027...64,019,879 		JBrowse link
G DYNC2H1 dynein cytoplasmic 2 heavy chain 1 acts_upstream_of_or_within ISO (PMID:21552265) MGI PMID:21552265 NCBI chr 5:28,566,604...28,727,416
Ensembl chr 5:28,388,664...28,727,334 		JBrowse link
G GBX1 gastrulation brain homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23418536) Ensembl
MGI		 PMID:23418536 GO_REF:0000107 NCBI chr16:15,195,705...15,213,425 JBrowse link
G GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 acts_upstream_of_or_within ISO (PMID:21943603) MGI PMID:21943603 NCBI chr21:23,070,875...23,157,078
Ensembl chr21:23,070,964...23,156,532 		JBrowse link
G GIGYF2 GRB10 interacting GYF protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19744960) Ensembl
MGI		 PMID:19744960 GO_REF:0000107 NCBI chr25:44,317,540...44,453,761
Ensembl chr25:44,317,517...44,452,064 		JBrowse link
G GLI2 GLI family zinc finger 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21552265) Ensembl
MGI		 PMID:21552265 GO_REF:0000107 NCBI chr19:29,128,401...29,383,324
Ensembl chr19:29,130,227...29,383,658 		JBrowse link
G GLI3 GLI family zinc finger 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21552265) Ensembl
MGI		 PMID:21552265 GO_REF:0000107 NCBI chr18:7,800,817...8,071,531
Ensembl chr18:7,801,394...8,068,132 		JBrowse link
G IFT172 intraflagellar transport 172 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21552265) Ensembl
MGI		 PMID:21552265 GO_REF:0000107 NCBI chr17:21,389,462...21,426,970
Ensembl chr17:21,389,482...21,426,796 		JBrowse link
G IGHMBP2 immunoglobulin mu DNA binding protein 2 acts_upstream_of_or_within ISO (PMID:19299493) MGI PMID:19299493 NCBI chr18:49,063,748...49,090,625
Ensembl chr18:49,064,609...49,091,453 		JBrowse link
G ISL1 ISL LIM homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:8565076) Ensembl
MGI		 PMID:8565076 GO_REF:0000107 NCBI chr 4:63,638,009...63,648,492
Ensembl chr 4:63,637,443...63,648,183 		JBrowse link
G LBX1 ladybird homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15769945) Ensembl
MGI		 PMID:15769945 GO_REF:0000107 NCBI chr28:13,872,846...13,875,521
Ensembl chr28:13,873,727...13,875,486 		JBrowse link
G LMO4 LIM domain only 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19666821) Ensembl
MGI		 PMID:19666821 GO_REF:0000107 NCBI chr 6:60,892,478...60,909,910
Ensembl chr 6:60,727,270...60,941,058 		JBrowse link
G MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 involved_in ISO PMID:15019943 HGNC-UCL PMID:15019943 RGD:8554528 NCBI chr 8:23,827,284...24,608,003
Ensembl chr 8:23,832,475...24,607,866 		JBrowse link
G MIR17 microRNA mir-17 acts_upstream_of_or_within ISO (PMID:21338882) MGI PMID:21338882 NCBI chr22:42,478,013...42,478,071
Ensembl chr22:42,478,000...42,478,083 		JBrowse link
G MIR18A microRNA mir-18a acts_upstream_of_or_within ISO (PMID:21338882) MGI PMID:21338882 NCBI chr22:42,478,138...42,478,229
Ensembl chr22:42,478,138...42,478,229 		JBrowse link
G MIR19A microRNA mir-19a acts_upstream_of_or_within ISO (PMID:21338882) MGI PMID:21338882 NCBI chr22:42,478,298...42,478,355
Ensembl chr22:42,478,285...42,478,366 		JBrowse link
G MIR19B-1 microRNA mir-19b-1 acts_upstream_of_or_within ISO (PMID:21741442) MGI PMID:21741442 NCBI chr22:42,478,598...42,478,656 JBrowse link
G MIR20A microRNA mir-20a acts_upstream_of_or_within ISO (PMID:21338882) MGI PMID:21338882 NCBI chr22:42,478,462...42,478,520
Ensembl chr22:42,478,462...42,478,520 		JBrowse link
G MIR92A-1 microRNA mir-92a-1 acts_upstream_of_or_within ISO (PMID:21338882) MGI PMID:21338882 NCBI chr22:42,478,714...42,478,772 JBrowse link
G NFE2L1 NFE2 like bZIP transcription factor 1 acts_upstream_of_or_within ISO (PMID:21554501) MGI PMID:21554501 NCBI chr 9:24,344,697...24,356,918
Ensembl chr 9:24,346,585...24,362,646 		JBrowse link
G NKX2-2 NK2 homeobox 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10217145) Ensembl
MGI		 PMID:10217145 GO_REF:0000107 NCBI chr24:1,933,176...1,935,875
Ensembl chr24:1,925,013...1,935,874 		JBrowse link
G OLIG2 oligodendrocyte transcription factor 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21338882) Ensembl
MGI		 PMID:21338882 GO_REF:0000107 NCBI chr31:27,674,112...27,677,521
Ensembl chr31:27,674,107...27,676,822 		JBrowse link
G OLIG3 oligodendrocyte transcription factor 3 acts_upstream_of_or_within ISO (PMID:15674731)
(PMID:15769945)		 MGI PMID:15674731 PMID:15769945 NCBI chr 1:29,919,043...29,921,713
Ensembl chr 1:29,920,190...29,921,008 		JBrowse link
G PTCH1 patched 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21552265) Ensembl
MGI		 PMID:21552265 GO_REF:0000107 NCBI chr 1:71,246,750...71,309,036
Ensembl chr 1:71,238,195...71,305,662 		JBrowse link
G SCYL1 SCY1 like pseudokinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:29437892) Ensembl
MGI		 PMID:29437892 GO_REF:0000107 NCBI chr18:51,667,647...51,680,904
Ensembl chr18:51,667,790...51,681,090 		JBrowse link
G SCYL3 SCY1 like pseudokinase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:29437892) Ensembl
MGI		 PMID:29437892 GO_REF:0000107 NCBI chr 7:28,751,604...28,796,042
Ensembl chr 7:28,751,707...28,795,756 		JBrowse link
G SHH sonic hedgehog signaling molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21552265) Ensembl
MGI		 PMID:21552265 GO_REF:0000107 NCBI chr16:18,650,553...18,663,571
Ensembl chr16:18,484,809...18,662,903 		JBrowse link
medial motor column neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LHX3 LIM homeobox 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9865699) Ensembl
MGI		 PMID:9865699 GO_REF:0000107 NCBI chr 9:49,248,555...49,254,128
Ensembl chr 9:49,248,621...49,254,118 		JBrowse link
G LHX4 LIM homeobox 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9865699) Ensembl
MGI		 PMID:9865699 GO_REF:0000107 NCBI chr 7:13,779,574...13,825,650
Ensembl chr 7:13,779,774...13,821,317 		JBrowse link
smoothened signaling pathway involved in spinal cord motor neuron cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLI2 GLI family zinc finger 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15215207) Ensembl
MGI		 PMID:15215207 GO_REF:0000107 NCBI chr19:29,128,401...29,383,324
Ensembl chr19:29,130,227...29,383,658 		JBrowse link
G GLI3 GLI family zinc finger 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15215207) Ensembl
MGI		 PMID:15215207 GO_REF:0000107 NCBI chr18:7,800,817...8,071,531
Ensembl chr18:7,801,394...8,068,132 		JBrowse link
G SUFU SUFU negative regulator of hedgehog signaling involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19684112) Ensembl
MGI		 PMID:19684112 GO_REF:0000107 NCBI chr28:14,992,989...15,115,499
Ensembl chr28:14,992,618...15,112,389 		JBrowse link
somatic motor neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLN8 CLN8 transmembrane ER and ERGIC protein acts_upstream_of_or_within ISO (PMID:21052544) MGI PMID:21052544 NCBI chr37:30,863,098...30,885,831
Ensembl chr37:30,867,479...30,884,895 		JBrowse link
G PHOX2A paired like homeobox 2A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16319924) Ensembl
MGI		 PMID:16319924 GO_REF:0000107 NCBI chr21:25,895,628...25,900,338
Ensembl chr21:25,892,321...25,900,351 		JBrowse link
G TCTN1 tectonic family member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16357211) Ensembl
MGI		 PMID:16357211 GO_REF:0000107 NCBI chr26:8,411,429...8,444,640
Ensembl chr26:8,407,105...8,437,027 		JBrowse link
spinal cord motor neuron cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HOXC10 homeobox C10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18065432) Ensembl
MGI		 PMID:18065432 GO_REF:0000107 NCBI chr27:1,272,272...1,277,411
Ensembl chr27:1,273,131...1,323,370 		JBrowse link
G HOXD10 homeobox D10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18065432) Ensembl
MGI		 PMID:18065432 GO_REF:0000107 NCBI chr36:19,924,352...19,927,706
Ensembl chr36:19,916,175...19,927,724 		JBrowse link
G ISL1 ISL LIM homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19666821) Ensembl
MGI		 PMID:19666821 GO_REF:0000107 NCBI chr 4:63,638,009...63,648,492
Ensembl chr 4:63,637,443...63,648,183 		JBrowse link
G ISL2 ISL LIM homeobox 2 acts_upstream_of_or_within ISO (PMID:19666821) MGI PMID:19666821
G LHX3 LIM homeobox 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19666821) Ensembl
MGI		 PMID:19666821 GO_REF:0000107 NCBI chr 9:49,248,555...49,254,128
Ensembl chr 9:49,248,621...49,254,118 		JBrowse link
G LMO4 LIM domain only 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:60,892,478...60,909,910
Ensembl chr 6:60,727,270...60,941,058 		JBrowse link
G MNX1 motor neuron and pancreas homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10482234) InterPro
TreeGrafter
MGI		 PMID:10482234 GO_REF:0000002 GO_REF:0000118 NCBI chr16:19,509,038...19,514,378
Ensembl chr16:19,499,582...19,512,836 		JBrowse link
G OLIG3 oligodendrocyte transcription factor 3 acts_upstream_of_or_within ISO (PMID:15769945) MGI PMID:15769945 NCBI chr 1:29,919,043...29,921,713
Ensembl chr 1:29,920,190...29,921,008 		JBrowse link
visceral motor neuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ISL1 ISL LIM homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14766174) Ensembl
MGI		 PMID:14766174 GO_REF:0000107 NCBI chr 4:63,638,009...63,648,492
Ensembl chr 4:63,637,443...63,648,183 		JBrowse link
G ISL2 ISL LIM homeobox 2 acts_upstream_of_or_within ISO (PMID:14766174) MGI PMID:14766174
G TBX20 T-box transcription factor 20 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:46,891,706...46,946,899
Ensembl chr14:46,896,228...46,947,507 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17878
    developmental process 6855
      anatomical structure development 6433
        ventral spinal cord development 56
          spinal cord motor neuron differentiation 40
            lateral motor column neuron differentiation 0
            somatic motor neuron differentiation + 5
            spinal cord motor neuron cell fate specification + 11
            visceral motor neuron differentiation 3
Path 2
Term Annotations click to browse term
  biological_process 17878
    developmental process 6855
      anatomical structure development 6433
        multicellular organism development 5182
          system development 4509
            nervous system development 2787
              neurogenesis 2079
                generation of neurons 1795
                  neuron differentiation 1714
                    central nervous system neuron differentiation 222
                      spinal cord motor neuron differentiation 40
                        lateral motor column neuron differentiation 0
                        somatic motor neuron differentiation + 5
                        spinal cord motor neuron cell fate specification + 11
                        visceral motor neuron differentiation 3
paths to the root