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ONTOLOGY REPORT - ANNOTATIONS


Term:spinal cord motor neuron differentiation
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Accession:GO:0021522 term browser browse the term
Definition:The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.


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spinal cord motor neuron differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abt1 activator of basal transcription 1 ISO MGI:99954 (MGI:3845694|PMID:19299493) RGD PMID:19299493 MGI:3845694 NCBI chr17:43,946,118...43,948,224
Ensembl chr17:43,946,130...43,948,223
JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A IEA
ISO
GO_REF:0000107
MGI:1856209|MGI:1856211 (MGI:3794823|PMID:17156092)
Ensembl
RGD
PMID:17156092 GO_REF:0000107, MGI:3794823 NCBI chr19:25,453,236...25,749,550
Ensembl chr19:25,526,751...25,749,550
JBrowse link
G Cln8 CLN8, transmembrane ER and ERGIC protein ISO MGI:1856959 (MGI:3709684|PMID:2061715) RGD PMID:2061715 MGI:3709684 NCBI chr16:79,828,321...79,838,212
Ensembl chr16:79,828,324...79,838,212
JBrowse link
G Dicer1 dicer 1 ribonuclease III ISO MGI:3589208 (MGI:5140688|PMID:21338882) RGD PMID:21338882 MGI:5140688 NCBI chr 6:128,388,084...128,453,234
Ensembl chr 6:128,388,053...128,434,183
JBrowse link
G Dync2h1 dynein cytoplasmic 2 heavy chain 1 IEA
ISO
GO_REF:0000107
MGI:105373|MGI:95729|MGI:98297 (MGI:5441704|PMID:21552265)
Ensembl
RGD
PMID:21552265 GO_REF:0000107, MGI:5441704 NCBI chr 8:5,217,054...5,436,969
Ensembl chr 8:5,217,217...5,429,581
JBrowse link
G Gbx1 gastrulation brain homeobox 1 ISO (MGI:5491108|PMID:23418536) RGD PMID:23418536 MGI:5491108 NCBI chr 4:7,173,961...7,200,752
Ensembl chr 4:7,173,961...7,200,752
JBrowse link
G Gdpd5 glycerophosphodiester phosphodiesterase domain containing 5 ISO MGI:5302017 (MGI:5299268|PMID:21943603) RGD PMID:21943603 MGI:5299268 NCBI chr 1:164,337,176...164,418,056
Ensembl chr 1:164,380,577...164,418,593
JBrowse link
G Gigyf2 GRB10 interacting GYF protein 2 ISO MGI:4126459 (MGI:4366664|PMID:19744960) RGD PMID:19744960 MGI:4366664 NCBI chr 9:94,425,191...94,550,431
Ensembl chr 9:94,425,252...94,550,431
JBrowse link
G Gli2 GLI family zinc finger 2 ISO MGI:1857509 (MGI:5441704|PMID:21552265) RGD PMID:21552265 MGI:5441704 NCBI chr13:34,829,021...35,049,172
Ensembl chr13:34,829,139...35,048,444
JBrowse link
G Gli3 GLI family zinc finger 3 ISO MGI:107736 (MGI:5441704|PMID:21552265) RGD PMID:21552265 MGI:5441704 NCBI chr17:52,294,942...52,569,036
Ensembl chr17:52,294,942...52,569,036
JBrowse link
G Ift172 intraflagellar transport 172 ISO MGI:2682066 (MGI:5441704|PMID:21552265) RGD PMID:21552265 MGI:5441704 NCBI chr 6:26,390,686...26,485,459 JBrowse link
G Ighmbp2 immunoglobulin mu DNA binding protein 2 ISO MGI:1857648 (MGI:3845694|PMID:19299493) RGD PMID:19299493 MGI:3845694 NCBI chr 1:218,509,274...218,531,922
Ensembl chr 1:218,508,950...218,532,142
JBrowse link
G Isl1 ISL LIM homeobox 1 ISO MGI:2182246 (MGI:78615|PMID:8565076) RGD PMID:8565076 MGI:78615 NCBI chr 2:48,488,911...48,501,217
Ensembl chr 2:48,487,736...48,501,436
JBrowse link
G Lbx1 ladybird homeobox 1 ISO MGI:2149955 (MGI:3531376|PMID:15769945) RGD PMID:15769945 MGI:3531376 NCBI chr 1:264,973,315...264,975,132
Ensembl chr 1:264,973,315...264,975,132
JBrowse link
G Lmo4 LIM domain only 4 ISO (MGI:4356383|PMID:19666821) RGD PMID:19666821 MGI:4356383 NCBI chr 2:250,218,635...250,235,435
Ensembl chr 2:250,218,641...250,241,673
JBrowse link
G Mdga2 MAM domain containing glycosylphosphatidylinositol anchor 2 IEP PMID:15019943 HGNC PMID:15019943 RGD:8554528 NCBI chr 6:88,442,620...89,292,454
Ensembl chr 6:88,447,749...88,917,070
JBrowse link
G Mir17 microRNA 17 ISO MGI:2676844|MGI:2676868|MGI:2676872|MGI:3618743|MGI:3619438|MGI:3629917|MGI:3629918|MGI:3790968 (MGI:5140688|PMID:21338882) RGD PMID:21338882 MGI:5140688 NCBI chr15:100,179,879...100,179,962
Ensembl chr15:100,179,879...100,179,962
JBrowse link
G Mir18a microRNA 18a ISO MGI:2676868|MGI:2676872|MGI:3618743|MGI:3619065|MGI:3619438|MGI:3629917|MGI:3629918 (MGI:5140688|PMID:21338882) RGD PMID:21338882 MGI:5140688 NCBI chr15:100,180,015...100,180,110
Ensembl chr15:100,180,015...100,180,110
JBrowse link
G Mir19a microRNA 19a ISO MGI:2676844|MGI:2676872|MGI:3619065|MGI:3629917|MGI:3629918 (MGI:5140688|PMID:21338882) RGD PMID:21338882 MGI:5140688 NCBI chr15:100,180,162...100,180,243
Ensembl chr15:100,180,162...100,180,243
JBrowse link
G Mir19b1 microRNA 19b-1 ISO MGI:2676844|MGI:2676872|MGI:3618743|MGI:3619065|MGI:3629918 (MGI:5139953|PMID:21741442) RGD PMID:21741442 MGI:5139953 NCBI chr15:100,180,464...100,180,550
Ensembl chr15:100,180,464...100,180,550
JBrowse link
G Mir20a microRNA 20a ISO MGI:2676844|MGI:3618743|MGI:3619065|MGI:3629917|MGI:3629918 (MGI:5140688|PMID:21338882) RGD PMID:21338882 MGI:5140688 NCBI chr15:100,180,334...100,180,418
Ensembl chr15:100,180,334...100,180,418
JBrowse link
G Mir92a1 microRNA 92a-1 ISO MGI:2676844|MGI:2676872|MGI:3618743|MGI:3619065|MGI:3629917 (MGI:5140688|PMID:21338882) RGD PMID:21338882 MGI:5140688 NCBI chr15:100,180,586...100,180,663
Ensembl chr15:100,180,586...100,180,663
JBrowse link
G Nfe2l1 nuclear factor, erythroid 2-like 1 ISO MGI:3828165 (MGI:5433806|PMID:21554501) RGD PMID:21554501 MGI:5433806 NCBI chr10:84,686,762...84,699,313
Ensembl chr10:84,682,460...84,698,886
JBrowse link
G Nkx2-2 NK2 homeobox 2 ISO MGI:1932100 (MGI:1334824|PMID:10217145) RGD PMID:10217145 MGI:1334824 NCBI chr 3:141,408,460...141,419,083
Ensembl chr 3:141,408,798...141,411,170
JBrowse link
G Olig2 oligodendrocyte transcription factor 2 ISO MGI:3774124 (MGI:5140688|PMID:21338882) RGD PMID:21338882 MGI:5140688 NCBI chr11:31,389,514...31,392,890
Ensembl chr11:31,389,514...31,392,890
JBrowse link
G Olig3 oligodendrocyte transcription factor 3 ISO MGI:104867|MGI:3573868 (MGI:3530702|PMID:15674731), (MGI:3531376|PMID:15769945) RGD PMID:15674731, PMID:15769945 MGI:3530702, MGI:3531376 NCBI chr 1:14,797,766...14,799,835
Ensembl chr 1:14,797,766...14,799,835
JBrowse link
G Ptch1 patched 1 ISO MGI:107736 (MGI:5441704|PMID:21552265) RGD PMID:21552265 MGI:5441704 NCBI chr17:1,032,242...1,085,885
Ensembl chr17:1,029,048...1,093,873
JBrowse link
G Scyl1 SCY1 like pseudokinase 1 ISO MGI:1921385|MGI:5469960 (MGI:6161057|PMID:29437892) RGD PMID:29437892 MGI:6161057 NCBI chr 1:221,115,992...221,129,668
Ensembl chr 1:221,115,860...221,129,654
JBrowse link
G Scyl3 SCY1 like pseudokinase 3 ISO MGI:1931787 (MGI:6161057|PMID:29437892) RGD PMID:29437892 MGI:6161057 NCBI chr13:82,230,938...82,255,640
Ensembl chr13:82,231,030...82,254,318
JBrowse link
G Shh sonic hedgehog signaling molecule IEA
ISO
GO_REF:0000107
MGI:107736 (MGI:5441704|PMID:21552265)
Ensembl
RGD
PMID:21552265 GO_REF:0000107, MGI:5441704 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link
G Sox4 SRY-box transcription factor 4 ISO (MGI:4838379|PMID:20646169) RGD PMID:20646169 MGI:4838379 NCBI chr17:37,615,022...37,619,728 JBrowse link
medial motor column neuron differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lhx3 LIM homeobox 3 ISO MGI:101776 (MGI:1316601|PMID:9865699) RGD PMID:9865699 MGI:1316601 NCBI chr 3:3,653,861...3,662,509
Ensembl chr 3:3,654,755...3,661,810
JBrowse link
G Lhx4 LIM homeobox 4 ISO MGI:102673 (MGI:1316601|PMID:9865699) RGD PMID:9865699 MGI:1316601 NCBI chr13:73,348,874...73,400,416
Ensembl chr13:73,348,842...73,400,416
JBrowse link
smoothened signaling pathway involved in spinal cord motor neuron cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli2 GLI family zinc finger 2 ISO MGI:95729 (MGI:3051712|PMID:15215207) RGD PMID:15215207 MGI:3051712 NCBI chr13:34,829,021...35,049,172
Ensembl chr13:34,829,139...35,048,444
JBrowse link
G Gli3 GLI family zinc finger 3 ISO MGI:95728 (MGI:3051712|PMID:15215207) RGD PMID:15215207 MGI:3051712 NCBI chr17:52,294,942...52,569,036
Ensembl chr17:52,294,942...52,569,036
JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling ISO MGI:4840420 (MGI:4355593|PMID:19684112) RGD PMID:19684112 MGI:4355593 NCBI chr 1:266,143,766...266,241,742
Ensembl chr 1:266,143,818...266,239,016
JBrowse link
somatic motor neuron differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cln8 CLN8, transmembrane ER and ERGIC protein ISO (MGI:4849309|PMID:21052544) RGD PMID:21052544 MGI:4849309 NCBI chr16:79,828,321...79,838,212
Ensembl chr16:79,828,324...79,838,212
JBrowse link
G Phox2a paired-like homeobox 2a IEA
ISO
GO_REF:0000107
MGI:3521825 (MGI:3761765|PMID:16319924)
Ensembl
RGD
PMID:16319924 GO_REF:0000107, MGI:3761765 NCBI chr 1:166,893,734...166,898,252
Ensembl chr 1:166,893,734...166,898,252
JBrowse link
G Tctn1 tectonic family member 1 ISO MGI:3716885 (MGI:3610767|PMID:16357211) RGD PMID:16357211 MGI:3610767 NCBI chr12:39,790,948...39,828,215
Ensembl chr12:39,790,965...39,824,064
JBrowse link
spinal cord motor neuron cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hoxc10 homeo box C10 ISO MGI:96202 (MGI:3771768|PMID:18065432) RGD PMID:18065432 MGI:3771768 NCBI chr 7:144,577,578...144,582,802
Ensembl chr 7:144,577,465...144,582,622
JBrowse link
G Hoxd10 homeo box D10 ISO MGI:96192 (MGI:3771768|PMID:18065432) RGD PMID:18065432 MGI:3771768 NCBI chr 3:61,614,133...61,617,342
Ensembl chr 3:61,613,774...61,617,367
JBrowse link
G Isl1 ISL LIM homeobox 1 ISO MGI:102673 (MGI:4356383|PMID:19666821) RGD PMID:19666821 MGI:4356383 NCBI chr 2:48,488,911...48,501,217
Ensembl chr 2:48,487,736...48,501,436
JBrowse link
G Isl2 ISL LIM homeobox 2 IEA
ISO
GO_REF:0000107
MGI:102673 (MGI:4356383|PMID:19666821)
Ensembl
RGD
PMID:19666821 GO_REF:0000107, MGI:4356383 NCBI chr 8:60,117,565...60,122,716
Ensembl chr 8:60,117,729...60,122,211
JBrowse link
G Lhx3 LIM homeobox 3 ISO MGI:101791|MGI:109156 (MGI:4356383|PMID:19666821) RGD PMID:19666821 MGI:4356383 NCBI chr 3:3,653,861...3,662,509
Ensembl chr 3:3,654,755...3,661,810
JBrowse link
G Mnx1 motor neuron and pancreas homeobox 1 IBA
ISO
PMID:21873635
MGI:2182358|MGI:2182361|MGI:2182363 (MGI:1344237|PMID:10482234)
RGD PMID:10482234, PMID:21873635 MGI:1344237, RGD:13792537 NCBI chr 4:2,376,350...2,381,308
Ensembl chr 4:2,376,958...2,381,271
JBrowse link
G Olig3 oligodendrocyte transcription factor 3 ISO MGI:3573868 (MGI:3531376|PMID:15769945) RGD PMID:15769945 MGI:3531376 NCBI chr 1:14,797,766...14,799,835
Ensembl chr 1:14,797,766...14,799,835
JBrowse link
visceral motor neuron differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Isl1 ISL LIM homeobox 1 ISO MGI:109156 (MGI:3041365|PMID:14766174) RGD PMID:14766174 MGI:3041365 NCBI chr 2:48,488,911...48,501,217
Ensembl chr 2:48,487,736...48,501,436
JBrowse link
G Isl2 ISL LIM homeobox 2 IEA
ISO
GO_REF:0000107
MGI:101791|MGI:3046260 (MGI:3041365|PMID:14766174)
Ensembl
RGD
PMID:14766174 GO_REF:0000107, MGI:3041365 NCBI chr 8:60,117,565...60,122,716
Ensembl chr 8:60,117,729...60,122,211
JBrowse link
G Tbx20 T-box transcription factor 20 ISO (MGI:3604925|PMID:15843409) RGD PMID:15843409 MGI:3604925 NCBI chr 8:25,849,394...25,904,570
Ensembl chr 8:25,850,962...25,904,570
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    developmental process 6826
      anatomical structure development 6268
        ventral spinal cord development 57
          spinal cord motor neuron differentiation 41
            lateral motor column neuron differentiation 0
            somatic motor neuron differentiation + 5
            spinal cord motor neuron cell fate specification + 10
            visceral motor neuron differentiation 3
Path 2
Term Annotations click to browse term
  biological_process 20020
    developmental process 6826
      anatomical structure development 6268
        multicellular organism development 5743
          system development 5279
            nervous system development 2719
              neurogenesis 1936
                generation of neurons 1780
                  neuron differentiation 1614
                    central nervous system neuron differentiation 240
                      spinal cord motor neuron differentiation 41
                        lateral motor column neuron differentiation 0
                        somatic motor neuron differentiation + 5
                        spinal cord motor neuron cell fate specification + 10
                        visceral motor neuron differentiation 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.