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ONTOLOGY REPORT - ANNOTATIONS

Term:ventral spinal cord interneuron differentiation
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Accession:GO:0021514 term browser browse the term
Definition:The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate.


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ventral spinal cord interneuron differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxn4 forkhead box N4 involved_in ISO (MGI:4834949|PMID:20844123) RGD PMID:20844123 MGI:4834949 NCBI chr12:42,336,706...42,359,932
Ensembl chr12:42,340,323...42,359,921 		JBrowse link
G Gata2 GATA binding protein 2 acts_upstream_of_or_within ISO MGI:1857743 (PMID:10934027) RGD PMID:10934027 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761 		JBrowse link
G Lmo4 LIM domain only 4 acts_upstream_of_or_within ISO (PMID:19666821) RGD PMID:19666821 NCBI chr 2:233,264,180...233,280,881
Ensembl chr 2:233,264,182...233,280,880 		JBrowse link
smoothened signaling pathway involved in ventral spinal cord interneuron specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli2 GLI family zinc finger 2 acts_upstream_of_or_within ISO MGI:95729 (PMID:15215207) RGD PMID:15215207 NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574 		JBrowse link
G Gli3 GLI family zinc finger 3 acts_upstream_of_or_within ISO MGI:95728 (PMID:15215207) RGD PMID:15215207 NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712 		JBrowse link
G Sufu SUFU negative regulator of hedgehog signaling acts_upstream_of_or_within ISO MGI:4840420 (PMID:19684112) RGD PMID:19684112 NCBI chr 1:245,257,725...245,355,576
Ensembl chr 1:245,257,768...245,355,577 		JBrowse link
ventral spinal cord interneuron fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl1 achaete-scute family bHLH transcription factor 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3587461|PMID:16020526)		 UniProt
RGD		 PMID:16020526 GO_REF:0000024 MGI:3587461 NCBI chr 7:21,903,136...21,906,003
Ensembl chr 7:21,903,126...21,905,993 		JBrowse link
G Dll4 delta like canonical Notch ligand 4 involved_in ISO
IEA		 UniProtKB:Q8K3Q3 (PMID:17728344)
GO_REF:0000107		 RGD
Ensembl		 PMID:17728344 GO_REF:0000107 NCBI chr 3:106,317,114...106,327,004
Ensembl chr 3:106,316,986...106,326,931 		JBrowse link
G Foxn4 forkhead box N4 involved_in ISO (MGI:3587461|PMID:16020526), (MGI:3765356|PMID:17728344) RGD PMID:16020526 PMID:17728344 MGI:3587461 MGI:3765356 NCBI chr12:42,336,706...42,359,932
Ensembl chr12:42,340,323...42,359,921 		JBrowse link
ventral spinal cord interneuron fate determination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nkx2-2 NK2 homeobox 2 acts_upstream_of_or_within ISO MGI:1932100 (PMID:10217145) RGD PMID:10217145 NCBI chr 3:134,619,701...134,630,282
Ensembl chr 3:134,620,039...134,622,411 		JBrowse link
ventral spinal cord interneuron specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dbx1 developing brain homeobox 1 acts_upstream_of_or_within ISO MGI:2182329 (PMID:11239429) RGD PMID:11239429 NCBI chr 1:99,348,638...99,354,173
Ensembl chr 1:99,349,608...99,354,038 		JBrowse link
G Dmrt3 doublesex and mab-3 related transcription factor 3 acts_upstream_of_or_within ISO MGI:4420993 (PMID:22932389) RGD PMID:22932389 NCBI chr 1:223,244,340...223,264,254
Ensembl chr 1:223,248,747...223,262,530 		JBrowse link
G Lhx3 LIM homeobox 3 acts_upstream_of_or_within ISO (PMID:19666821) RGD PMID:19666821 NCBI chr 3:9,026,432...9,035,122
Ensembl chr 3:9,027,425...9,034,480 		JBrowse link
G Shh sonic hedgehog signaling molecule acts_upstream_of_or_within IDA PMID:9230312 MGI PMID:9230312 RGD:8553789 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Sox1 SRY-box transcription factor 1 acts_upstream_of_or_within ISO MGI:3653406 (PMID:20844123) RGD PMID:20844123 NCBI chr16:77,135,577...77,139,592
Ensembl chr16:77,137,584...77,138,762 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    developmental process 7068
      anatomical structure development 6575
        ventral spinal cord development 57
          ventral spinal cord interneuron differentiation 14
            ventral spinal cord interneuron fate commitment + 12
Path 2
Term Annotations click to browse term
  biological_process 20413
    developmental process 7068
      anatomical structure development 6575
        multicellular organism development 5290
          system development 4576
            nervous system development 2835
              neurogenesis 2096
                generation of neurons 1808
                  neuron differentiation 1726
                    central nervous system neuron differentiation 222
                      ventral spinal cord interneuron differentiation 14
                        ventral spinal cord interneuron fate commitment + 12
paths to the root