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ONTOLOGY REPORT - ANNOTATIONS

Term:chemokine binding
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Accession:GO:0019956 term browser browse the term
Definition:Interacting selectively and non-covalently with a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.

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chemokine binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcr3 C-X-C motif chemokine receptor 3 enables ISO UniProtKB:O43927 (PMID:11554781) RGD PMID:11554781 NCBI chr  X:71,614,346...71,616,997
Ensembl chr  X:71,614,346...71,616,997 		JBrowse link
G Fgf2 fibroblast growth factor 2 enables ISO UniProtKB:O43927 (PMID:11708770) RGD PMID:11708770 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681 		JBrowse link
G Pdpn podoplanin enables IBA
ISO		 PMID:21873635
UniProtKB:O00585 (PMID:14978162)		 RGD PMID:14978162, PMID:21873635 RGD:13792537 NCBI chr 5:161,947,137...161,981,441
Ensembl chr 5:161,947,137...161,981,441 		JBrowse link
G Plp2 proteolipid protein 2 enables ISO UniProtKB:P32246 (PMID:15474493) RGD PMID:15474493 NCBI chr  X:15,679,254...15,682,653
Ensembl chr  X:15,679,254...15,682,652 		JBrowse link
C-C chemokine binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ackr1 atypical chemokine receptor 1 enables ISO UniProtKB:P13501 (PMID:7517217) RGD PMID:7517217 NCBI chr13:91,827,310...91,828,875 JBrowse link
G Ackr2 atypical chemokine receptor 2 enables IEA
ISO
IBA		 GO_REF:0000107
UniProtKB:P13501 (MGI:87663|PMID:9139699)
PMID:21873635		 Ensembl
RGD		 PMID:9139699, PMID:21873635 GO_REF:0000107 MGI:87663, RGD:13792537 NCBI chr 8:130,526,521...130,543,566
Ensembl chr 8:130,538,651...130,542,227 		JBrowse link
G Ackr3 atypical chemokine receptor 3 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:97,355,881...97,367,455
Ensembl chr 9:97,355,924...97,367,445 		JBrowse link
G Ackr4 atypical chemokine receptor 4 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:112,643,838...112,651,668
Ensembl chr 8:112,644,222...112,648,880 		JBrowse link
G Ccr1 C-C motif chemokine receptor 1 enables IDA
IBA
ISO		 PMID:21873635
UniProtKB:P10147|UniProtKB:P13236|UniProtKB:P55773 (PMID:10660125), (PMID:15764707), (PMID:7545673), (PMID:8699119)		 RGD PMID:7545673 PMID:8699119 PMID:10660125 PMID:15764707, PMID:11091494, PMID:21873635 RGD:5688180, RGD:13792537 NCBI chr 8:132,996,646...133,002,201
Ensembl chr 8:132,996,649...133,002,201 		JBrowse link
G Ccr10 C-C motif chemokine receptor 10 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:89,086,556...89,088,993
Ensembl chr10:89,086,556...89,088,993 		JBrowse link
G Ccr1l1 chemokine (C-C motif) receptor 1-like 1 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:133,127,220...133,128,290
Ensembl chr 8:133,127,220...133,128,290 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Ccr3 C-C motif chemokine receptor 3 enables ISO
IEA
IBA		 (PMID:11425309)
GO_REF:0000107
UniProtKB:Q9Y4X3 (MGI:5897759|PMID:12538707)
PMID:21873635		 RGD
Ensembl		 PMID:11425309 PMID:12538707, PMID:21873635 GO_REF:0000107 MGI:5897759, RGD:13792537 NCBI chr 8:133,026,539...133,040,999
Ensembl chr 8:133,029,625...133,040,997 		JBrowse link
G Ccr4 C-C motif chemokine receptor 4 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:122,530,152...122,535,959
Ensembl chr 8:122,530,624...122,532,070 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 enables ISO
IBA		 UniProtKB:P10147|UniProtKB:P13236|UniProtKB:P32246 (PMID:10383387), (PMID:10679098), (PMID:8699119)
UniProtKB:P13501 (MGI:87663|PMID:9139699)
PMID:21873635		 RGD PMID:8699119 PMID:9139699 PMID:10383387 PMID:10679098, PMID:21873635 MGI:87663, RGD:13792537 NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614 		JBrowse link
G Ccr6 C-C motif chemokine receptor 6 enables ISO
IBA		 (PMID:12081481), (PMID:20068036)
(MGI:5784982|PMID:20068036)
PMID:21873635		 RGD PMID:12081481 PMID:20068036, PMID:21873635 MGI:5784982, RGD:13792537 NCBI chr 1:53,063,380...53,087,519
Ensembl chr 1:53,065,025...53,087,474 		JBrowse link
G Ccr7 C-C motif chemokine receptor 7 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456 		JBrowse link
G Ccr8 C-C motif chemokine receptor 8 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:128,779,552...128,782,531
Ensembl chr 8:128,781,395...128,782,456 		JBrowse link
G Ccr9 C-C motif chemokine receptor 9 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:132,827,325...132,842,130
Ensembl chr 8:132,828,091...132,842,130 		JBrowse link
G Ccrl2 C-C motif chemokine receptor like 2 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:119,324,298...119,326,954
Ensembl chr 8:119,324,613...119,326,938 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:128,740,756...128,754,514
Ensembl chr 8:128,740,756...128,754,514 		JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:81,466,430...81,469,299
Ensembl chr 9:81,466,332...81,469,274 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:81,427,275...81,435,065
Ensembl chr 9:81,427,730...81,434,102 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:71,614,346...71,616,997
Ensembl chr  X:71,614,346...71,616,997 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 enables ISO
IBA		 UniProtKB:Q98157 (PMID:25612609)
PMID:21873635		 RGD PMID:25612609, PMID:21873635 RGD:13792537 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878 		JBrowse link
G Cxcr5 C-X-C motif chemokine receptor 5 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:48,835,688...48,852,032
Ensembl chr 8:48,836,957...48,850,671 		JBrowse link
G Cxcr6 C-X-C motif chemokine receptor 6 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:132,869,712...132,870,766
Ensembl chr 8:132,869,712...132,870,767 		JBrowse link
G Xcr1 X-C motif chemokine receptor 1 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:132,911,474...132,919,110
Ensembl chr 8:132,911,486...132,919,110 		JBrowse link
G Zfp36 zinc finger protein 36 enables ISO
IEA		 UniProtKB:P10147 (PMID:21784977)
GO_REF:0000107		 RGD
Ensembl		 PMID:21784977 GO_REF:0000107 NCBI chr 1:85,380,088...85,382,565
Ensembl chr 1:85,380,088...85,382,569 		JBrowse link
C-X-C chemokine binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ackr3 atypical chemokine receptor 3 enables ISS
ISO		 GO_REF:0000024
(PMID:22300987)		 UniProt
RGD		 PMID:22300987 GO_REF:0000024 NCBI chr 9:97,355,881...97,367,455
Ensembl chr 9:97,355,924...97,367,445 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 enables ISO
ISS		 (PMID:12782716)
GO_REF:0000024		 RGD
UniProt		 PMID:12782716 GO_REF:0000024 NCBI chr  X:71,614,346...71,616,997
Ensembl chr  X:71,614,346...71,616,997 		JBrowse link
G Cxcr6 C-X-C motif chemokine receptor 6 enables ISO UniProtKB:Q8BSU2 (MGI:1891794|PMID:11017100) RGD PMID:11017100 MGI:1891794 NCBI chr 8:132,869,712...132,870,766
Ensembl chr 8:132,869,712...132,870,767 		JBrowse link
G Hmgb1 high mobility group box 1 enables ISO (PMID:22370717) RGD PMID:22370717 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237 		JBrowse link
C-X3-C chemokine binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cx3cr1 C-X3-C motif chemokine receptor 1 enables ISS
ISO		 GO_REF:0000024
UniProtKB:P78423 (MGI:6162594|PMID:10187784)
(PMID:23125415)		 UniProt
RGD		 PMID:10187784 PMID:23125415 GO_REF:0000024 MGI:6162594 NCBI chr 8:128,740,756...128,754,514
Ensembl chr 8:128,740,756...128,754,514 		JBrowse link
G Itga4 integrin subunit alpha 4 contributes_to ISO (PMID:23125415) RGD PMID:23125415 NCBI chr 3:66,178,745...66,265,547
Ensembl chr 3:66,193,059...66,263,960 		JBrowse link
G Itgav integrin subunit alpha V contributes_to ISO (PMID:23125415) RGD PMID:23125415 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411 		JBrowse link
G Itgb1 integrin subunit beta 1 contributes_to
enables		 ISO
IEA
IBA
ISS		 (PMID:23125415)
GO_REF:0000107
PMID:21873635
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:23125415, PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535 		JBrowse link
G Itgb3 integrin subunit beta 3 contributes_to ISO (PMID:23125415) RGD PMID:23125415 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410 		JBrowse link
chemokine (C-C motif) ligand 12 binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr2 C-C motif chemokine receptor 2 enables ISO UniProtKB:Q62401 (MGI:84964|PMID:8996246) RGD PMID:8996246 MGI:84964
chemokine (C-C motif) ligand 19 binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr7 C-C motif chemokine receptor 7 enables ISO
IBA		 UniProtKB:O70460 (PMID:9507024)
PMID:21873635		 RGD PMID:9507024, PMID:21873635 RGD:13792537 NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456 		JBrowse link
chemokine (C-C motif) ligand 2 binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr2 C-C motif chemokine receptor 2 enables ISO UniProtKB:P10148 (MGI:80507|PMID:8662823) RGD PMID:8662823 MGI:80507
chemokine (C-C motif) ligand 21 binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr7 C-C motif chemokine receptor 7 enables IBA
ISO		 PMID:21873635
UniProtKB:P84444 (PMID:9507024)		 RGD PMID:9507024, PMID:21873635 RGD:13792537 NCBI chr10:87,057,335...87,067,444
Ensembl chr10:87,057,136...87,067,456 		JBrowse link
chemokine (C-C motif) ligand 5 binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr1 C-C motif chemokine receptor 1 enables ISO
IBA		 UniProtKB:P13501 (PMID:10660125), (PMID:10734056), (PMID:7545673), (PMID:8699119)
PMID:21873635		 RGD PMID:7545673 PMID:8699119 PMID:10660125 PMID:10734056, PMID:21873635 RGD:13792537 NCBI chr 8:132,996,646...133,002,201
Ensembl chr 8:132,996,649...133,002,201 		JBrowse link
G Ccr1l1 chemokine (C-C motif) receptor 1-like 1 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:133,127,220...133,128,290
Ensembl chr 8:133,127,220...133,128,290 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Ccr5 C-C motif chemokine receptor 5 enables IBA
ISO
IEA		 PMID:21873635
UniProtKB:P13501 (PMID:8699119)
GO_REF:0000107		 RGD
Ensembl		 PMID:8699119, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614 		JBrowse link
chemokine (C-C motif) ligand 7 binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr1 C-C motif chemokine receptor 1 enables ISO
IBA		 UniProtKB:P80098 (PMID:10660125), (PMID:7545673)
PMID:21873635		 RGD PMID:7545673 PMID:10660125, PMID:21873635 RGD:13792537 NCBI chr 8:132,996,646...133,002,201
Ensembl chr 8:132,996,649...133,002,201 		JBrowse link
G Ccr1l1 chemokine (C-C motif) receptor 1-like 1 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:133,127,220...133,128,290
Ensembl chr 8:133,127,220...133,128,290 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 enables ISO UniProtKB:Q03366 (MGI:80507|PMID:8662823) RGD PMID:8662823 MGI:80507
interleukin-8 binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin enables ISO UniProtKB:P10145 (PMID:10880251) RGD PMID:10880251 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
Ensembl chr 4:154,309,426...154,359,137 		JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 enables ISO UniProtKB:P10145 (PMID:11564821) RGD PMID:11564821 NCBI chr 9:81,466,430...81,469,299
Ensembl chr 9:81,466,332...81,469,274 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 enables IEA
ISO		 GO_REF:0000002
UniProtKB:P10145 (PMID:1840701)		 InterPro
RGD		 PMID:1840701 GO_REF:0000002 NCBI chr 9:81,427,275...81,435,065
Ensembl chr 9:81,427,730...81,434,102 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20076
    binding 17050
      protein binding 14352
        cytokine binding 145
          chemokine binding 34
            C-C chemokine binding + 25
            C-X-C chemokine binding + 7
            C-X3-C chemokine binding 5
paths to the root