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ONTOLOGY REPORT - ANNOTATIONS

Term:cAMP-mediated signaling
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Accession:GO:0019933 term browser browse the term
Definition:An intracellular signaling cassette that starts with production of cyclic AMP (cAMP), and ends with activation of downstream effectors that further transmit the signal within the cell.
Synonyms:exact_synonym: 3',5' cAMP-mediated signaling;   3',5' cAMP-mediated signalling;   adenosine 3',5'-cyclophosphate-mediated signaling;   adenosine 3',5'-cyclophosphate-mediated signalling;   cAMP signaling;   cAMP signalling;   cAMP-mediated signal transduction;   cAMP-mediated signalling;   cyclic AMP-mediated signaling;   cyclic AMP-mediated signalling


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cAMP-mediated signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cap1 cyclase associated actin cytoskeleton regulatory protein 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:135,142,108...135,168,885
Ensembl chr 5:135,142,112...135,168,769 		JBrowse link
G Cap2 cyclase associated actin cytoskeleton regulatory protein 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:18,054,234...18,203,453
Ensembl chr17:18,054,431...18,203,373 		JBrowse link
G Cgas cyclic GMP-AMP synthase involved_in ISO
IEA 		(PMID:23258413), (PMID:24077100)
GO_REF:0000107 		RGD
Ensembl		 PMID:23258413 PMID:24077100 GO_REF:0000107 NCBI chr 8:79,292,282...79,306,998
Ensembl chr 8:79,294,511...79,305,496 		JBrowse link
G Crem cAMP responsive element modulator TAS RGD PMID:7809053 RGD:1298796 NCBI chr17:58,932,011...59,001,160
Ensembl chr17:54,239,030...54,305,989 		JBrowse link
G Dorip1 dopamine receptor interacting protein 1 acts_upstream_of_or_within_positive_effect ISO
IEA 		(PMID:37248637)
GO_REF:0000107 		RGD
Ensembl		 PMID:37248637 GO_REF:0000107 NCBI chr 6:82,965,304...82,973,942
Ensembl chr 6:82,965,328...82,972,558 		JBrowse link
G Lep leptin TAS RGD PMID:12101402 RGD:625547 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Pde10a phosphodiesterase 10A involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563 		JBrowse link
G Pde11a phosphodiesterase 11A involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:60,913,562...61,297,154
Ensembl chr 3:60,913,562...61,297,158 		JBrowse link
G Pde11a_v3 phosphodiesterase 11A, variant 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Pde1a phosphodiesterase 1A involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:85,152,053...85,432,289
Ensembl chr 3:64,747,269...65,024,874 		JBrowse link
G Pde1b phosphodiesterase 1B involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:136,505,834...136,533,034
Ensembl chr 7:134,627,322...134,654,580 		JBrowse link
G Pde1c phosphodiesterase 1C involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:85,300,858...85,777,948
Ensembl chr 4:85,300,858...85,863,219 		JBrowse link
G Pde2a phosphodiesterase 2A involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:165,235,623...165,327,466
Ensembl chr 1:155,813,180...155,915,434 		JBrowse link
G Pde3a phosphodiesterase 3A involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:175,904,276...176,170,531
Ensembl chr 4:174,172,868...174,438,274 		JBrowse link
G Pde3b phosphodiesterase 3B involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:178,041,207...178,204,503
Ensembl chr 1:168,607,022...168,769,334 		JBrowse link
G Pde4a phosphodiesterase 4A involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:19,690,816...19,753,538
Ensembl chr 8:19,703,290...19,751,961 		JBrowse link
G Pde4b phosphodiesterase 4B involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:122,028,956...122,598,267
Ensembl chr 5:116,799,971...117,367,696 		JBrowse link
G Pde4c phosphodiesterase 4C involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:18,690,727...18,711,555
Ensembl chr16:18,691,700...18,710,640 		JBrowse link
G Pde4d phosphodiesterase 4D involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:41,748,337...43,262,567
Ensembl chr 2:40,019,933...41,525,884 		JBrowse link
G Pde5a phosphodiesterase 5A involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:213,542,822...213,687,638
Ensembl chr 2:210,858,063...210,999,701 		JBrowse link
G Pde6a phosphodiesterase 6A involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:54,676,863...54,748,640
Ensembl chr18:54,676,863...54,748,816 		JBrowse link
G Pde6b phosphodiesterase 6B involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:1,323,310...1,366,450
Ensembl chr14:1,323,310...1,366,450 		JBrowse link
G Pde6c phosphodiesterase 6C involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:235,909,583...235,965,435
Ensembl chr 1:235,909,775...235,965,315 		JBrowse link
G Pde7a phosphodiesterase 7A involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:101,714,767...101,806,853
Ensembl chr 2:101,718,444...101,806,681 		JBrowse link
G Pde7b phosphodiesterase 7B involved_in TAS
IBA 		GO_REF:0000033 GO_Central
RGD		 PMID:11772393 GO_REF:0000033, RGD:625534 NCBI chr 1:15,174,001...15,493,267
Ensembl chr 1:15,182,704...15,492,900 		JBrowse link
G Pde7b_v3 phosphodiesterase 7B, variant 3 NAS RGD PMID:11772393 RGD:625534
G Pde8a phosphodiesterase 8A involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:135,166,143...135,288,986
Ensembl chr 1:135,166,237...135,288,024 		JBrowse link
G Pde8b phosphodiesterase 8B involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:26,275,117...26,479,725
Ensembl chr 2:26,276,635...26,509,209 		JBrowse link
G Pde9a phosphodiesterase 9A involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:9,469,809...9,562,949
Ensembl chr20:9,469,848...9,562,948 		JBrowse link
negative regulation of cAMP-mediated signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplnr apelin receptor involved_in ISS
ISO
IBA
IEA 		GO_REF:0000024
(PMID:25639753)
GO_REF:0000033
GO_REF:0000107 		UniProt
RGD
GO_Central
Ensembl		 PMID:25639753 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:90,624,055...90,627,700
Ensembl chr 3:70,217,385...70,221,050 		JBrowse link
positive regulation of cAMP-mediated signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nrxn1 neurexin 1 involved_in ISO (PMID:26078884) RGD PMID:26078884 NCBI chr 6:8,931,360...10,077,381
Ensembl chr 6:3,177,897...4,322,710 		JBrowse link
G Tor2a torsin family 2, member A involved_in ISO (PMID:12910263) RGD PMID:12910263 NCBI chr 3:16,048,591...16,053,198
Ensembl chr 3:16,048,549...16,052,634 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      signal transduction 7313
        intracellular signal transduction 3197
          intracellular signaling cassette 2057
            cAMP-mediated signaling 32
              negative regulation of cAMP-mediated signaling 1
              positive regulation of cAMP-mediated signaling 2
              regulation of cAMP-mediated signaling + 3
Path 2
Term Annotations click to browse term
  biological_process 20543
    biological regulation 13835
      regulation of biological process 13398
        signaling 7874
          signal transduction 7313
            intracellular signal transduction 3197
              intracellular signaling cassette 2057
                cAMP-mediated signaling 32
                  negative regulation of cAMP-mediated signaling 1
                  positive regulation of cAMP-mediated signaling 2
                  regulation of cAMP-mediated signaling + 3
paths to the root