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ONTOLOGY REPORT - ANNOTATIONS


Term:cyclin-dependent protein kinase activating kinase holoenzyme complex
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Accession:GO:0019907 term browser browse the term
Definition:A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH.
Synonyms:exact_synonym: CAK complex;   CDK-activating kinase complex



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cyclin-dependent protein kinase activating kinase holoenzyme complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnh cyclin H part_of ISO (PMID:23393140), (PMID:8692841), (PMID:8692842) RGD PMID:8692841 PMID:8692842 PMID:23393140 NCBI chr 2:15,834,833...15,855,643
Ensembl chr 2:15,834,833...15,855,819
JBrowse link
G Cdk7 cyclin-dependent kinase 7 part_of ISO
IEA
(PMID:23393140), (PMID:8692841)
GO_REF:0000107
RGD
Ensembl
PMID:8692841 PMID:23393140 GO_REF:0000107 NCBI chr 2:31,840,545...31,865,447
Ensembl chr 2:31,840,558...31,865,383
JBrowse link
G Mnat1 MNAT1 component of CDK activating kinase part_of ISO (PMID:11445587), (PMID:8692841) RGD PMID:8692841 PMID:11445587 NCBI chr 6:91,814,703...91,971,945
Ensembl chr 6:91,814,749...91,970,744
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19969
    protein-containing complex 6165
      enzyme activator complex 4
        cyclin-dependent protein kinase activating kinase holoenzyme complex 3
Path 2
Term Annotations click to browse term
  cellular_component 19969
    protein-containing complex 6165
      catalytic complex 1549
        transferase complex 831
          transferase complex, transferring phosphorus-containing groups 280
            protein kinase complex 128
              serine/threonine protein kinase complex 109
                cyclin-dependent protein kinase holoenzyme complex 52
                  nuclear cyclin-dependent protein kinase holoenzyme complex 13
                    cyclin-dependent protein kinase activating kinase holoenzyme complex 3
paths to the root