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ONTOLOGY REPORT - ANNOTATIONS


Term:cyclin-dependent protein kinase activating kinase holoenzyme complex
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Accession:GO:0019907 term browser browse the term
Definition:A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH.
Synonyms:exact_synonym: CAK complex;   CDK-activating kinase complex



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cyclin-dependent protein kinase activating kinase holoenzyme complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNH cyclin H part_of IEA Ensembl GO_REF:0000107 NCBI chr 2:94,980,938...95,019,053
Ensembl chr 2:94,980,940...95,018,726
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G CDK7 cyclin dependent kinase 7 part_of IEA Ensembl GO_REF:0000107 NCBI chr16:47,410,136...47,445,795
Ensembl chr16:47,410,144...47,449,356
JBrowse link
G MNAT1 MNAT1 component of CDK activating kinase part_of IEA Ensembl GO_REF:0000107 NCBI chr 1:189,690,343...189,908,144
Ensembl chr 1:189,690,354...189,910,589
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 17057
    protein-containing complex 5220
      enzyme activator complex 5
        cyclin-dependent protein kinase activating kinase holoenzyme complex 3
Path 2
Term Annotations click to browse term
  cellular_component 17057
    protein-containing complex 5220
      catalytic complex 1433
        transferase complex 785
          transferase complex, transferring phosphorus-containing groups 265
            protein kinase complex 127
              serine/threonine protein kinase complex 109
                cyclin-dependent protein kinase holoenzyme complex 52
                  nuclear cyclin-dependent protein kinase holoenzyme complex 13
                    cyclin-dependent protein kinase activating kinase holoenzyme complex 3
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