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ONTOLOGY REPORT - ANNOTATIONS


Term:cyclin-dependent protein kinase activating kinase holoenzyme complex
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Accession:GO:0019907 term browser browse the term
Definition:A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH.
Synonyms:exact_synonym: CAK complex;   CDK-activating kinase complex



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cyclin-dependent protein kinase activating kinase holoenzyme complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNH cyclin H part_of ISO (PMID:23393140)
(PMID:8692841), (PMID:8692842)
CAFA
UniProt
PMID:8692841 PMID:8692842 PMID:23393140 NCBI chr 3:21,046,477...21,067,305
Ensembl chr 3:21,046,472...21,178,315
JBrowse link
G CDK7 cyclin dependent kinase 7 part_of ISO (PMID:8692841)
(PMID:23393140)
UniProt
CAFA
PMID:8692841 PMID:23393140 NCBI chr 2:54,317,472...54,350,633
Ensembl chr 2:54,317,534...54,350,742
JBrowse link
G MNAT1 MNAT1 component of CDK activating kinase part_of IEA Ensembl GO_REF:0000107 NCBI chr 8:35,747,883...35,946,353
Ensembl chr 8:35,756,933...35,946,353
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 14080
    protein-containing complex 4722
      enzyme activator complex 5
        cyclin-dependent protein kinase activating kinase holoenzyme complex 3
Path 2
Term Annotations click to browse term
  cellular_component 14080
    protein-containing complex 4722
      catalytic complex 1307
        transferase complex 705
          transferase complex, transferring phosphorus-containing groups 231
            protein kinase complex 111
              serine/threonine protein kinase complex 94
                cyclin-dependent protein kinase holoenzyme complex 43
                  nuclear cyclin-dependent protein kinase holoenzyme complex 12
                    cyclin-dependent protein kinase activating kinase holoenzyme complex 3
paths to the root