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ONTOLOGY REPORT - ANNOTATIONS

Term:L-ascorbic acid biosynthetic process
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Accession:GO:0019853 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions.
Synonyms:exact_synonym: L-ascorbic acid anabolism;   L-ascorbic acid biosynthesis;   L-ascorbic acid formation;   L-ascorbic acid synthesis;   ascorbate biosynthesis;   ascorbate biosynthetic process;   vitamin C biosynthesis;   vitamin C biosynthetic process
 never_in_taxon: NCBITaxon:4890 ! Ascomycota;   NCBITaxon:9606 ! Homo sapiens


show annotations for term's descendants           Sort by:
L-ascorbic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1 member A1 involved_in
acts_upstream_of_or_within 		IMP
ISO
IEA 		PMID:22820017
MGI:4239556 (PMID:20410296)
(PMID:15769935)
GO_REF:0000107
GO_REF:0000117 		RGD
Ensembl
UniProt		 PMID:15769935 PMID:20410296 PMID:22820017 GO_REF:0000107 GO_REF:0000117, RGD:13825440 NCBI chr 5:135,329,605...135,367,037
Ensembl chr 5:135,329,606...135,367,035 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 involved_in ISO MGI:5008171 (PMID:20410296) RGD PMID:20410296 NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:63,899,222...63,913,315 		JBrowse link
G Gsto1 glutathione S-transferase omega 1 IMP RGD PMID:9786866 RGD:70644 NCBI chr 1:256,662,377...256,672,515
Ensembl chr 1:256,662,531...256,676,167 		JBrowse link
G Gulo gulonolactone (L-) oxidase involved_in ISS
IEA 		GO_REF:0000024
GO_REF:0000107
GO_REF:0000043 		UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000043 GO_REF:0000107 NCBI chr15:40,205,677...40,227,766
Ensembl chr15:44,381,214...44,403,422 		JBrowse link
G Rgn regucalcin involved_in ISS
IBA
ISO
IEA 		GO_REF:0000024
GO_REF:0000033
MGI:2670511 (PMID:16585534), (PMID:23349732)
GO_REF:0000043 		UniProt
GO_Central
RGD		 PMID:16585534 PMID:23349732 GO_REF:0000024 GO_REF:0000033 GO_REF:0000043 NCBI chr  X:4,172,537...4,190,112
Ensembl chr  X:4,172,537...4,190,251 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20668
    cellular process 19605
      metabolic process 12252
        biosynthetic process 8769
          lactone biosynthetic process 5
            L-ascorbic acid biosynthetic process 5
              L-ascorbic acid biosynthetic process via GDP-alpha-D-mannose 0
              L-ascorbic acid biosynthetic process via UDP-alpha-D-glucuronate 0
              negative regulation of L-ascorbic acid biosynthetic process 0
              regulation of L-ascorbic acid biosynthetic process + 0
Path 2
Term Annotations click to browse term
  biological_process 20668
    cellular process 19605
      metabolic process 12252
        small molecule metabolic process 1977
          organic acid metabolic process 1082
            oxoacid metabolic process 1068
              carboxylic acid metabolic process 1053
                L-ascorbic acid metabolic process 14
                  L-ascorbic acid biosynthetic process 5
                    L-ascorbic acid biosynthetic process via GDP-alpha-D-mannose 0
                    L-ascorbic acid biosynthetic process via UDP-alpha-D-glucuronate 0
                    negative regulation of L-ascorbic acid biosynthetic process 0
                    regulation of L-ascorbic acid biosynthetic process + 0
paths to the root