L-ascorbic acid biosynthetic process - Ontology Report

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ONTOLOGY REPORT - ANNOTATIONS	{{ watchLinkText }}

Term:	L-ascorbic acid biosynthetic process	go back to main search page
Accession:	GO:0019853	browse the term
Definition:	The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions.
Synonyms:	exact_synonym:	L-ascorbic acid anabolism; L-ascorbic acid biosynthesis; L-ascorbic acid formation; L-ascorbic acid synthesis; ascorbate biosynthesis; ascorbate biosynthetic process; vitamin C biosynthesis; vitamin C biosynthetic process
	xref:	MetaCyc:PWY-882

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Genes (5)

L-ascorbic acid biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Akr1a1

aldo-keto reductase family 1 member A1

involved_in
acts_upstream_of_or_within

ISO
IMP

MGI:4239556 (MGI:4834110|PMID:20410296)
(MGI:3588122|PMID:15769935)
PMID:22820017

RGD

PMID:15769935 PMID:20410296 PMID:22820017

MGI:3588122 MGI:4834110, RGD:13825440

NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674

Akr1b1

aldo-keto reductase family 1 member B1

involved_in

ISO

MGI:5008171 (MGI:4834110|PMID:20410296)

RGD

PMID:20410296

MGI:4834110

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

Gsto1

glutathione S-transferase omega 1

IMP

RGD

PMID:9786866

RGD:70644

NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468

Gulo

gulonolactone (L-) oxidase

involved_in

ISS
IEA

GO_REF:0000024
GO_REF:0000107

UniProt
Ensembl

GO_REF:0000024 GO_REF:0000107

NCBI chr15:40,205,677...40,227,766
Ensembl chr15:40,205,665...40,227,874

Rgn

regucalcin

involved_in

ISS
IBA
ISO

GO_REF:0000024
PMID:21873635
MGI:2670511 (MGI:3623658|PMID:16585534), (MGI:5486063|PMID:23349732)

UniProt
RGD

PMID:16585534 PMID:23349732 PMID:21873635

GO_REF:0000024 MGI:3623658 MGI:5486063, RGD:13792537

NCBI chr X:1,619,030...1,634,456
Ensembl chr X:1,619,032...1,634,450

Term paths to the root

Path 1
Term	Annotations
biological_process	19746
metabolic process	12044
small molecule metabolic process	1892
monosaccharide metabolic process	287
monosaccharide biosynthetic process	107
L-ascorbic acid biosynthetic process	5
L-ascorbic acid biosynthetic process via GDP-alpha-D-mannose	0
L-ascorbic acid biosynthetic process via UDP-alpha-D-glucuronate	0
negative regulation of L-ascorbic acid biosynthetic process	0
regulation of L-ascorbic acid biosynthetic process +	0
Path 2
Term	Annotations
biological_process	19746
cellular process	18159
cellular metabolic process	9531
organic acid metabolic process	1055
oxoacid metabolic process	1044
carboxylic acid metabolic process	1029
L-ascorbic acid metabolic process	10
L-ascorbic acid biosynthetic process	5
L-ascorbic acid biosynthetic process via GDP-alpha-D-mannose	0
L-ascorbic acid biosynthetic process via UDP-alpha-D-glucuronate	0
negative regulation of L-ascorbic acid biosynthetic process	0
regulation of L-ascorbic acid biosynthetic process +	0

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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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ONTOLOGY REPORT - ANNOTATIONS