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ONTOLOGY REPORT - ANNOTATIONS


Term:L-ascorbic acid biosynthetic process
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Accession:GO:0019853 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions.
Synonyms:exact_synonym: L-ascorbic acid anabolism;   L-ascorbic acid biosynthesis;   L-ascorbic acid formation;   L-ascorbic acid synthesis;   ascorbate biosynthesis;   ascorbate biosynthetic process;   vitamin C biosynthesis;   vitamin C biosynthetic process
 xref: MetaCyc:PWY-882



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L-ascorbic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1 member A1 involved_in
acts_upstream_of_or_within
ISO
IMP
MGI:4239556 (MGI:4834110|PMID:20410296)
(MGI:3588122|PMID:15769935)
PMID:22820017
RGD PMID:15769935 PMID:20410296 PMID:22820017 MGI:3588122 MGI:4834110, RGD:13825440 NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 involved_in ISO MGI:5008171 (MGI:4834110|PMID:20410296) RGD PMID:20410296 MGI:4834110 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
JBrowse link
G Gsto1 glutathione S-transferase omega 1 IMP RGD PMID:9786866 RGD:70644 NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468
JBrowse link
G Gulo gulonolactone (L-) oxidase involved_in ISS
IEA
GO_REF:0000024
GO_REF:0000107
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr15:40,205,677...40,227,766
Ensembl chr15:40,205,665...40,227,874
JBrowse link
G Rgn regucalcin involved_in ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
MGI:2670511 (MGI:3623658|PMID:16585534), (MGI:5486063|PMID:23349732)
UniProt
RGD
PMID:16585534 PMID:23349732 PMID:21873635 GO_REF:0000024 MGI:3623658 MGI:5486063, RGD:13792537 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19746
    metabolic process 12044
      small molecule metabolic process 1892
        monosaccharide metabolic process 287
          monosaccharide biosynthetic process 107
            L-ascorbic acid biosynthetic process 5
              L-ascorbic acid biosynthetic process via GDP-alpha-D-mannose 0
              L-ascorbic acid biosynthetic process via UDP-alpha-D-glucuronate 0
              negative regulation of L-ascorbic acid biosynthetic process 0
              regulation of L-ascorbic acid biosynthetic process + 0
Path 2
Term Annotations click to browse term
  biological_process 19746
    cellular process 18159
      cellular metabolic process 9531
        organic acid metabolic process 1055
          oxoacid metabolic process 1044
            carboxylic acid metabolic process 1029
              L-ascorbic acid metabolic process 10
                L-ascorbic acid biosynthetic process 5
                  L-ascorbic acid biosynthetic process via GDP-alpha-D-mannose 0
                  L-ascorbic acid biosynthetic process via UDP-alpha-D-glucuronate 0
                  negative regulation of L-ascorbic acid biosynthetic process 0
                  regulation of L-ascorbic acid biosynthetic process + 0
paths to the root