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ONTOLOGY REPORT - ANNOTATIONS

Term:growth factor binding
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Accession:GO:0019838 term browser browse the term
Definition:Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.
Synonyms:related_synonym: neurotrophin TRK receptor activity
 never_in_taxon: NCBITaxon:2 ! Bacteria;   NCBITaxon:2157 ! Archaea;   NCBITaxon:4751 ! Fungi

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growth factor binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin enables ISO (PMID:9398211) UniProt PMID:9398211 NCBI chrNW_004936870:424,832...468,303 JBrowse link
G Acvr1 activin A receptor type 1 ISO (MGI:73273|PMID:8388127) MGI PMID:8388127 MGI:73273 NCBI chrNW_004936469:20,743,195...20,811,567 JBrowse link
G Acvr1b activin A receptor type 1B contributes_to ISO (PMID:14517293) HGNC PMID:14517293 NCBI chrNW_004936512:9,407,578...9,449,611 JBrowse link
G Acvr1c activin A receptor type 1C enables ISO (PMID:21805089) UniProt PMID:21805089 NCBI chrNW_004936469:20,892,715...20,964,674 JBrowse link
G Acvr2a activin A receptor type 2A ISO (MGI:2389524|PMID:12414726)
(MGI:2137985|PMID:11459935)		 MGI PMID:11459935 PMID:12414726 MGI:2137985 MGI:2389524 NCBI chrNW_004936469:29,195,329...29,273,237 JBrowse link
G Acvr2b activin A receptor type 2B enables ISO (MGI:2137985|PMID:11459935)
(PMID:14517293)
(MGI:2389524|PMID:12414726)		 MGI
HGNC-UCL		 PMID:11459935 PMID:12414726 PMID:14517293 MGI:2137985 MGI:2389524 NCBI chrNW_004936473:27,816,366...27,822,555 JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 ISO RGD PMID:11044210 RGD:5129485 NCBI chrNW_004936726:1,543,263...1,711,422 JBrowse link
G Dusp1 dual specificity phosphatase 1 ISO RGD PMID:18929742 RGD:10044027 NCBI chrNW_004936609:2,688,170...2,691,057 JBrowse link
G Epha2 EPH receptor A2 enables ISO (PMID:22568954) ARUK-UCL PMID:22568954 NCBI chrNW_004936474:3,648,395...3,673,856 JBrowse link
G Epha5 EPH receptor A5 enables ISO PMID:22568954 ARUK-UCL PMID:22568954 RGD:40902966 NCBI chrNW_004936582:2,503,546...2,832,950 JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 contributes_to ISO (PMID:7514177) BHF-UCL PMID:7514177 NCBI chrNW_004936490:14,887,062...14,910,038 JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 enables ISO (PMID:11389077) BHF-UCL PMID:11389077 NCBI chrNW_004936646:497,783...515,247 JBrowse link
G Flt1 fms related receptor tyrosine kinase 1 enables ISO (PMID:12366396)
(PMID:10471394), (PMID:11513746), (PMID:1312256)
(PMID:12366396), (PMID:16109918)		 RGD
UniProt		 PMID:1312256 PMID:10471394 PMID:11513746 PMID:12366396 PMID:16109918 PMID:17651752 RGD:2289969 NCBI chrNW_004936472:23,442,946...23,617,523 JBrowse link
G Flt4 fms related receptor tyrosine kinase 4 enables ISO (PMID:9435229) RGD
UniProt		 PMID:9435229 PMID:11683876 RGD:727326 NCBI chrNW_004936739:240,572...281,925 JBrowse link
G Ghr growth hormone receptor enables ISO (PMID:9360546) BHF-UCL PMID:9360546 NCBI chrNW_004936518:235,996...380,225 JBrowse link
G Ghrhr growth hormone releasing hormone receptor enables ISO (PMID:7680413) BHF-UCL PMID:7680413 NCBI chrNW_004936478:7,188,826...7,202,854 JBrowse link
G Il6st interleukin 6 cytokine family signal transducer contributes_to
enables		 ISO (PMID:8999038) BHF-UCL PMID:8999038 NCBI chrNW_004936480:11,867,573...11,913,563 JBrowse link
G Kdr kinase insert domain receptor enables ISO (PMID:10022831), (PMID:1417831)
(MGI:1860784|PMID:10705382)
(MGI:83765|PMID:7681362)		 RGD
BHF-UCL
MGI		 PMID:1417831 PMID:7681362 PMID:9160888 PMID:9442048 PMID:10022831 PMID:10705382 MGI:1860784 MGI:83765 RGD:2292115 RGD:729081 NCBI chrNW_004936482:17,537,697...17,581,320 JBrowse link
G Lifr LIF receptor subunit alpha enables ISO (PMID:8999038) BHF-UCL PMID:8999038 NCBI chrNW_004936518:3,651,630...3,693,072 JBrowse link
G Nkd2 NKD inhibitor of WNT signaling pathway 2 enables ISO (PMID:15064403) BHF-UCL PMID:15064403 NCBI chrNW_004936815:669,389...701,402 JBrowse link
G Nrp1 neuropilin 1 enables ISO (MGI:1860784|PMID:10705382)
(PMID:9529250)		 MGI
UniProt		 PMID:9529250 PMID:10705382 MGI:1860784 NCBI chrNW_004936574:1,694,433...1,834,720 JBrowse link
G Osmr oncostatin M receptor enables ISO (PMID:8999038) BHF-UCL PMID:8999038 NCBI chrNW_004936518:3,320,057...3,381,518 JBrowse link
G Pdxp pyridoxal phosphatase ISO RGD PMID:18929742 RGD:10044027 NCBI chrNW_004936492:3,420,590...3,426,764 JBrowse link
G Sdcbp syndecan binding protein ISO RGD PMID:11152476 RGD:633988 NCBI chrNW_004936496:14,331,971...14,347,123 JBrowse link
G Tek TEK receptor tyrosine kinase ISO RGD PMID:15714275 RGD:1578337 NCBI chrNW_004936611:2,420,176...2,531,726 JBrowse link
G Tgfbr1 transforming growth factor beta receptor 1 contributes_to ISO (PMID:14517293) HGNC PMID:14517293 NCBI chrNW_004936524:7,656,523...7,680,043 JBrowse link
G Vegfa vascular endothelial growth factor A ISO RGD PMID:17881084 RGD:2292001 NCBI chrNW_004936476:16,245,134...16,261,180 JBrowse link
brain-derived neurotrophic factor binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin ISO RGD PMID:11813239 RGD:10046023 NCBI chrNW_004936870:424,832...468,303 JBrowse link
G Fstl4 follistatin like 4 ISO (MGI:5566541|PMID:24573299) MGI PMID:24573299 MGI:5566541 NCBI chrNW_004936647:1,783,065...1,997,203 JBrowse link
G Hap1 huntingtin associated protein 1 enables ISO PMID:19996106
PMID:21357693		 UniProt PMID:19996106 PMID:21357693 RGD:10047154 RGD:10047187 NCBI chrNW_004936490:16,645,116...16,652,310 JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 enables ISO PMID:1645620
(MGI:893826|PMID:1645620)		 UniProt
RGD		 PMID:1645620 PMID:16477614 PMID:16983663 MGI:893826 RGD:1626130 RGD:1626131 RGD:8554777 NCBI chrNW_004936680:267,850...621,467 JBrowse link
epidermal growth factor binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egfr epidermal growth factor receptor ISO (MGI:52273|PMID:7678348) RGD
MGI		 PMID:7678348 PMID:15486316 MGI:52273 RGD:1581908 NCBI chrNW_004936678:365,005...560,546 JBrowse link
G Sec61b SEC61 translocon subunit beta enables ISO (PMID:19602593) UniProt PMID:19602593 NCBI chrNW_004936524:7,731,033...7,739,410 JBrowse link
G Shc1 SHC adaptor protein 1 ISO (MGI:3057041|PMID:15467833) UniProt PMID:15467833 MGI:3057041 NCBI chrNW_004936580:4,511,560...4,522,003 JBrowse link
fibroblast growth factor binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Api5 apoptosis inhibitor 5 enables ISO (PMID:11075807) UniProt PMID:11075807 NCBI chrNW_004936562:5,229,157...5,253,175 JBrowse link
G Cep57 centrosomal protein 57 enables ISO (PMID:12717444) UniProt PMID:12717444 NCBI chrNW_004936700:1,874,509...1,914,688 JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 enables ISO (PMID:11708770) BHF-UCL PMID:11708770 NCBI chrNW_004936676:1,309,625...1,314,532 JBrowse link
G Fgfbp3 fibroblast growth factor binding protein 3 enables ISO (MGI:4949582|PMID:20851768)
(PMID:18669637)		 UniProt
MGI		 PMID:18669637 PMID:20851768 MGI:4949582 NCBI chrNW_004936601:2,735,898...2,736,889 JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 enables ISO (MGI:79015|PMID:2161540)
(PMID:18480409), (PMID:8663044)
(MGI:3696596|PMID:17086194)		 MGI
UniProt		 PMID:2161540 PMID:8663044 PMID:17086194 PMID:18480409 MGI:3696596 MGI:79015 NCBI chrNW_004936710:1,760,365...1,815,269 JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 enables ISO (PMID:11923311), (PMID:19224135)
(PMID:8386828)
(PMID:8663044)
(MGI:1197797|PMID:9435295)
Fgfr2IIIb/Kgfr isoform		 RGD
UniProt
MGI		 PMID:7803853 PMID:8386828 PMID:8663044 PMID:9435295 PMID:11042206 PMID:11923311 PMID:15282342 PMID:19224135 MGI:1197797 RGD:2289853 RGD:632663 RGD:6480435 NCBI chrNW_004936486:10,506,680...10,606,272 JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 enables ISO (PMID:8663044)
(PMID:12815063)		 RGD
UniProt
MGI		 PMID:8663044 PMID:12815063 PMID:15231666 RGD:1304345 NCBI chrNW_004936477:21,591,772...21,606,289 JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 enables ISO (PMID:10525310), (PMID:17627937)
(PMID:18480409), (PMID:8663044)		 UniProt PMID:8663044 PMID:10525310 PMID:17627937 PMID:18480409 NCBI chrNW_004936597:1,388,394...1,397,731 JBrowse link
G Fgfrl1 fibroblast growth factor receptor like 1 ISO (MGI:2148330|PMID:11418238), (MGI:2673744|PMID:12813049) MGI PMID:11418238 PMID:12813049 MGI:2148330 MGI:2673744 NCBI chrNW_004936477:22,177,473...22,189,554 JBrowse link
G Fibp FGF1 intracellular binding protein enables ISO (PMID:9806903) MGI PMID:9806903 NCBI chrNW_004936599:3,652,889...3,657,171 JBrowse link
G Glg1 golgi glycoprotein 1 ISO RGD PMID:7768993 RGD:68884 NCBI chrNW_004936475:23,411,194...23,534,692 JBrowse link
G Gpc1 glypican 1 ISO (MGI:4461098|PMID:20100867) UniProt PMID:20100867 MGI:4461098 NCBI chrNW_004936745:1,118,732...1,127,169 JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 ISO RGD PMID:10510314 PMID:15030183 RGD:10402562 RGD:6784522 NCBI chrNW_004936531:7,702,186...7,716,428 JBrowse link
G Itgav integrin subunit alpha V contributes_to ISO (PMID:18441324) UniProtKB PMID:18441324 NCBI chrNW_004936506:10,750,116...10,839,018 JBrowse link
G Itgb3 integrin subunit beta 3 contributes_to ISO (PMID:18441324) UniProtKB PMID:18441324 NCBI chrNW_004936541:2,822,789...2,871,069 JBrowse link
G Kl klotho enables ISO (MGI:3696596|PMID:17086194)
(PMID:18829467)		 UniProt PMID:17086194 PMID:18829467 MGI:3696596 NCBI chrNW_004936472:27,604,681...27,649,613 JBrowse link
G Klb klotho beta enables ISO (PMID:18829467)
(PMID:19117008)		 UniProt PMID:18829467 PMID:19117008 NCBI chrNW_004936482:7,026,871...7,060,495 JBrowse link
G LOC101976958 fibroblast growth factor-binding protein 1 ISO (MGI:4949582|PMID:20851768)
(MGI:3589509|PMID:15806171)		 UniProt
MGI		 PMID:15806171 PMID:20851768 MGI:3589509 MGI:4949582 NCBI chrNW_004936477:12,030,140...12,032,626 JBrowse link
G Ptprz1 protein tyrosine phosphatase receptor type Z1 ISO RGD PMID:9705269 RGD:9589122 NCBI chrNW_004936605:3,195,893...3,368,102 JBrowse link
G Rps19 ribosomal protein S19 enables ISO (PMID:11716516) BHF-UCL PMID:11716516 NCBI chrNW_004936706:568,443...575,973 JBrowse link
G Rps2 ribosomal protein S2 enables ISO (PMID:16263090) UniProt PMID:16263090 NCBI chrNW_004936694:2,071,295...2,073,409 JBrowse link
G S100a13 S100 calcium binding protein A13 enables ISO (PMID:11432880) UniProt PMID:11432880 NCBI chrNW_004936580:3,420,016...3,429,009 JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 enables ISO (PMID:12401812) RGD
BHF-UCL		 PMID:12401812 RGD:6484231 NCBI chrNW_004936473:27,883,526...27,963,994 JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 ISO RGD PMID:1556106 RGD:1579950 NCBI chrNW_004936537:7,154,125...7,340,218 JBrowse link
G Thbs1 thrombospondin 1 enables ISO (PMID:17996481) BHF-UCL PMID:17996481 NCBI chrNW_004936471:3,064,466...3,081,125 JBrowse link
hepatocyte growth factor binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Srpx2 sushi repeat containing protein X-linked 2 enables ISO (PMID:22242148) UniProt PMID:22242148 NCBI chrNW_004936584:5,855,818...5,879,478 JBrowse link
insulin-like growth factor binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Igf1r insulin like growth factor 1 receptor enables ISO (MGI:2679358|PMID:14566968)
(PMID:1846292), (PMID:7679099)		 MGI
UniProt		 PMID:1846292 PMID:7679099 PMID:14566968 MGI:2679358 NCBI chrNW_004936483:4,563,995...4,860,231 JBrowse link
G Igf2r insulin like growth factor 2 receptor ISO (MGI:2679358|PMID:14566968) MGI PMID:14566968 MGI:2679358 NCBI chrNW_004936489:11,447,043...11,523,695 JBrowse link
G Igfals insulin like growth factor binding protein acid labile subunit ISO RGD PMID:12446576 RGD:1299153 NCBI chrNW_004936694:2,205,294...2,207,343 JBrowse link
G Igfbp1 insulin like growth factor binding protein 1 ISO (MGI:52244|PMID:7679139) MGI PMID:7679139 MGI:52244 NCBI chrNW_004936478:20,494,190...20,499,001 JBrowse link
G Igfbp2 insulin like growth factor binding protein 2 ISO (MGI:52244|PMID:7679139) MGI PMID:7679139 MGI:52244 NCBI chrNW_004936586:671,760...696,783 JBrowse link
G Igfbp3 insulin like growth factor binding protein 3 ISO (MGI:52244|PMID:7679139) MGI PMID:7679139 MGI:52244 NCBI chrNW_004936478:20,511,490...20,518,251 JBrowse link
G Igfbp4 insulin like growth factor binding protein 4 ISO (MGI:52244|PMID:7679139) MGI PMID:7679139 MGI:52244 NCBI chrNW_004936490:15,482,483...15,494,402 JBrowse link
G Igfbp5 insulin like growth factor binding protein 5 ISO (MGI:2679358|PMID:14566968) RGD
MGI		 PMID:1709938 PMID:14566968 MGI:2679358 RGD:69857 NCBI chrNW_004936586:647,553...666,595 JBrowse link
insulin-like growth factor I binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Igf1r insulin like growth factor 1 receptor enables ISO (PMID:19578119)
(PMID:8452530)		 UniProt
BHF-UCL		 PMID:8452530 PMID:19578119 NCBI chrNW_004936483:4,563,995...4,860,231 JBrowse link
G Igfbp1 insulin like growth factor binding protein 1 enables ISO (PMID:21550830) UniProt PMID:21550830 NCBI chrNW_004936478:20,494,190...20,499,001 JBrowse link
G Igfbp2 insulin like growth factor binding protein 2 enables ISO PMID:2538475
(PMID:19081843)		 UniProt PMID:2538475 PMID:19081843 RGD:729148 NCBI chrNW_004936586:671,760...696,783 JBrowse link
G Igfbp3 insulin like growth factor binding protein 3 enables ISO (PMID:10766744) BHF-UCL PMID:10766744 NCBI chrNW_004936478:20,511,490...20,518,251 JBrowse link
G Igfbp5 insulin like growth factor binding protein 5 enables ISO (PMID:10766744) BHF-UCL PMID:10766744 NCBI chrNW_004936586:647,553...666,595 JBrowse link
G Igfbp6 insulin like growth factor binding protein 6 ISO binds with low affinity RGD PMID:7689963 RGD:2301726 NCBI chrNW_004936512:10,415,004...10,419,698 JBrowse link
G Insr insulin receptor enables ISO (PMID:8452530) BHF-UCL PMID:8452530 NCBI chrNW_004936588:4,345,306...4,453,380 JBrowse link
G Itga6 integrin subunit alpha 6 enables ISO (PMID:22351760) UniProt PMID:22351760 NCBI chrNW_004936509:2,508,446...2,587,643 JBrowse link
G Itgav integrin subunit alpha V contributes_to ISO (PMID:19578119) BHF-UCL PMID:19578119 NCBI chrNW_004936506:10,750,116...10,839,018 JBrowse link
G Itgb3 integrin subunit beta 3 contributes_to ISO (PMID:19578119) UniProtKB PMID:19578119 NCBI chrNW_004936541:2,822,789...2,871,069 JBrowse link
G Itgb4 integrin subunit beta 4 contributes_to ISO (PMID:22351760) UniProtKB PMID:22351760 NCBI chrNW_004936594:912,302...944,819 JBrowse link
G Lrp2 LDL receptor related protein 2 enables ISO PMID:16306401 ARUK-UCL PMID:16306401 RGD:14697713 NCBI chrNW_004936469:10,245,001...10,438,933 JBrowse link
insulin-like growth factor II binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Igf2r insulin like growth factor 2 receptor ISO RGD PMID:16407557 RGD:1624326 NCBI chrNW_004936489:11,447,043...11,523,695 JBrowse link
G Igfbp1 insulin like growth factor binding protein 1 enables ISO (PMID:21550830) UniProt PMID:21550830 NCBI chrNW_004936478:20,494,190...20,499,001 JBrowse link
G Igfbp2 insulin like growth factor binding protein 2 enables ISO PMID:2538475
PMID:2974285		 RGD
UniProt		 PMID:1709938 PMID:2538475 PMID:2974285 RGD:69857 RGD:729148 RGD:8553840 NCBI chrNW_004936586:671,760...696,783 JBrowse link
G Igfbp3 insulin like growth factor binding protein 3 ISO RGD PMID:9346943 RGD:1626111 NCBI chrNW_004936478:20,511,490...20,518,251 JBrowse link
G Igfbp6 insulin like growth factor binding protein 6 enables ISO binds with high affinity
(PMID:15308688)		 RGD
CAFA		 PMID:7689963 PMID:15308688 RGD:2301726 NCBI chrNW_004936512:10,415,004...10,419,698 JBrowse link
G Insr insulin receptor enables ISO (PMID:12138094) BHF-UCL PMID:12138094 NCBI chrNW_004936588:4,345,306...4,453,380 JBrowse link
interleukin-1 binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin enables ISO (PMID:9714181) UniProt PMID:9714181 NCBI chrNW_004936870:424,832...468,303 JBrowse link
G Hax1 HCLS1 associated protein X-1 enables ISO (PMID:11554782) UniProt PMID:11554782 NCBI chrNW_004936580:3,961,433...3,964,322 JBrowse link
G Il1r1 interleukin 1 receptor type 1 ISO (MGI:5468848|PMID:23395675) MGI PMID:23395675 MGI:5468848 NCBI chrNW_004936713:808,761...881,070 JBrowse link
G Il1r2 interleukin 1 receptor type 2 ISO (MGI:5468848|PMID:23395675) MGI PMID:23395675 MGI:5468848 NCBI chrNW_004936713:679,680...716,801 JBrowse link
G LOC101956766 interleukin-1 receptor accessory protein-like 1 NOT|enables ISO (PMID:12783849) UniProt PMID:12783849 NCBI chrNW_004936553:6,055,190...6,099,427 JBrowse link
G Trim16 tripartite motif containing 16 enables ISO (PMID:16575408) UniProt PMID:16575408 NCBI chrNW_004936724:2,101,942...2,122,747 JBrowse link
interleukin-1 receptor antagonist activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1rn interleukin 1 receptor antagonist enables ISO (PMID:2137200), (PMID:2139180) BHF-UCL PMID:2137200 PMID:2139180 NCBI chrNW_004936783:1,447,158...1,466,331 JBrowse link
interleukin-1 type I receptor antagonist activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1rn interleukin 1 receptor antagonist enables ISO (PMID:1828071) BHF-UCL PMID:1828071 NCBI chrNW_004936783:1,447,158...1,466,331 JBrowse link
interleukin-1 type II receptor antagonist activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1rn interleukin 1 receptor antagonist enables ISO (PMID:1830582) BHF-UCL PMID:1830582 NCBI chrNW_004936783:1,447,158...1,466,331 JBrowse link
interleukin-10 binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10ra interleukin 10 receptor subunit alpha ISO RGD PMID:12405978 PMID:19428551 RGD:2311043 RGD:729323 NCBI chrNW_004936542:3,099,484...3,113,159 JBrowse link
interleukin-11 binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il11ra interleukin 11 receptor subunit alpha ISO (MGI:69257|PMID:7957045) MGI PMID:7957045 MGI:69257 NCBI chrNW_004936524:2,732,477...2,743,044 JBrowse link
G Il6st interleukin 6 cytokine family signal transducer contributes_to ISO (MGI:69257|PMID:7957045) MGI PMID:7957045 MGI:69257 NCBI chrNW_004936480:11,867,573...11,913,563 JBrowse link
interleukin-2 binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il2ra interleukin 2 receptor subunit alpha ISO (MGI:64265|PMID:8262055) MGI PMID:8262055 MGI:64265 NCBI chrNW_004936484:8,514,333...8,555,392 JBrowse link
G Il2rb interleukin 2 receptor subunit beta enables ISO (PMID:2467293), (PMID:31040184), (PMID:31040185)
(MGI:64265|PMID:8262055)		 RGD
UniProt
MGI		 PMID:1469024 PMID:2467293 PMID:8262055 PMID:31040184 PMID:31040185 MGI:64265 RGD:2303496 NCBI chrNW_004936492:3,795,940...3,805,822 JBrowse link
G Il2rg interleukin 2 receptor subunit gamma ISO (MGI:64265|PMID:8262055) MGI PMID:8262055 MGI:64265 NCBI chrNW_004936762:487,414...491,028 JBrowse link
interleukin-6 binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6r interleukin 6 receptor enables ISO (MGI:50330|PMID:1312474)
(PMID:12829785)		 MGI
BHF-UCL		 PMID:1312474 PMID:12829785 MGI:50330 NCBI chrNW_004936580:4,055,438...4,081,876 JBrowse link
G Il6st interleukin 6 cytokine family signal transducer contributes_to ISO (PMID:12829785) BHF-UCL PMID:12829785 NCBI chrNW_004936480:11,867,573...11,913,563 JBrowse link
interleukin-9 binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il9r interleukin 9 receptor ISO RGD PMID:7966560 RGD:633086 NCBI chrNW_004936501:829,236...840,130 JBrowse link
nerve growth factor binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin ISO RGD PMID:11813239 RGD:10046023 NCBI chrNW_004936870:424,832...468,303 JBrowse link
G Furin furin, paired basic amino acid cleaving enzyme enables ISO (PMID:8615794) BHF-UCL PMID:8615794 NCBI chrNW_004936483:16,136,099...16,147,945 JBrowse link
G Ngfr nerve growth factor receptor ISO (MGI:1098517|PMID:1317267) RGD
MGI		 PMID:1317267 PMID:3027580 MGI:1098517 RGD:728964 NCBI chrNW_004936490:12,038,500...12,057,257 JBrowse link
G Ntf3 neurotrophin 3 ISO RGD PMID:2164684 RGD:729140 NCBI chrNW_004936709:2,163,510...2,223,429 JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 enables
NOT|enables		 ISO (PMID:1281417), (PMID:15488758), (PMID:17196528)
(PMID:15488758)		 RGD
UniProt		 PMID:1281417 PMID:9753156 PMID:15488758 PMID:17196528 RGD:5508802 NCBI chrNW_004936580:6,002,168...6,021,690 JBrowse link
G Pcsk6 proprotein convertase subtilisin/kexin type 6 enables ISO (PMID:8615794) BHF-UCL PMID:8615794 NCBI chrNW_004936483:2,374,357...2,561,322 JBrowse link
G Sort1 sortilin 1 enables ISO (PMID:14985763) BHF-UCL PMID:14985763 NCBI chrNW_004936704:832,651...901,658 JBrowse link
neuregulin binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Erbb3 erb-b2 receptor tyrosine kinase 3 enables ISO (PMID:20682778) RGD
UniProt		 PMID:14711829 PMID:20682778 RGD:2289958 NCBI chrNW_004936646:497,783...515,247 JBrowse link
G Itga6 integrin subunit alpha 6 enables ISO (PMID:20682778) UniProt PMID:20682778 NCBI chrNW_004936509:2,508,446...2,587,643 JBrowse link
G Itgav integrin subunit alpha V contributes_to ISO (PMID:20682778) UniProtKB PMID:20682778 NCBI chrNW_004936506:10,750,116...10,839,018 JBrowse link
G Itgb3 integrin subunit beta 3 contributes_to ISO (PMID:20682778) UniProtKB PMID:20682778 NCBI chrNW_004936541:2,822,789...2,871,069 JBrowse link
G Itgb4 integrin subunit beta 4 contributes_to ISO (PMID:20682778) UniProtKB PMID:20682778 NCBI chrNW_004936594:912,302...944,819 JBrowse link
neurotrophin binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ngfr nerve growth factor receptor ISO RGD PMID:18596692 RGD:5508745 NCBI chrNW_004936490:12,038,500...12,057,257 JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 enables ISO PMID:1645620
(PMID:11738045)
(MGI:893826|PMID:1645620)		 UniProt PMID:1645620 PMID:11738045 MGI:893826 RGD:8554777 NCBI chrNW_004936680:267,850...621,467 JBrowse link
platelet-derived growth factor binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col1a1 collagen type I alpha 1 chain enables ISO (PMID:8900172) MGI PMID:8900172 NCBI chrNW_004936490:11,448,552...11,465,836 JBrowse link
G Col1a2 collagen type I alpha 2 chain enables ISO (PMID:8900172) MGI PMID:8900172 NCBI chrNW_004936585:5,650,322...5,686,393 JBrowse link
G Col2a1 collagen type II alpha 1 chain enables ISO (PMID:8900172) MGI PMID:8900172 NCBI chrNW_004936512:5,861,933...5,894,898 JBrowse link
G Col3a1 collagen type III alpha 1 chain enables ISO (PMID:8900172) MGI PMID:8900172 NCBI chrNW_004936506:8,886,494...8,923,921 JBrowse link
G Col4a1 collagen type IV alpha 1 chain enables ISO (PMID:8900172) MGI PMID:8900172 NCBI chrNW_004936472:2,416,043...2,543,561 JBrowse link
G Col5a1 collagen type V alpha 1 chain enables ISO (PMID:8900172) MGI PMID:8900172 NCBI chrNW_004936669:2,474,381...2,613,541 JBrowse link
G Col6a1 collagen type VI alpha 1 chain enables ISO (PMID:8900172) MGI PMID:8900172 NCBI chrNW_004936778:515,600...530,828 JBrowse link
G Pdgfa platelet derived growth factor subunit A enables ISO (PMID:7073684) BHF-UCL PMID:7073684 NCBI chrNW_004936754:808,894...828,554 JBrowse link
G Pdgfb platelet derived growth factor subunit B enables ISO (PMID:7073684) BHF-UCL PMID:7073684 NCBI chrNW_004936492:2,353,840...2,368,573 JBrowse link
G Pdgfra platelet derived growth factor receptor alpha enables ISO (MGI:3056973|PMID:15372073), (MGI:5294530|PMID:20110689)
(PMID:2536956)
(PMID:2554309), (PMID:8188664)
(PMID:10806482)		 UniProt
BHF-UCL		 PMID:2536956 PMID:2554309 PMID:8188664 PMID:10806482 PMID:15372073 PMID:20110689 MGI:3056973 MGI:5294530 NCBI chrNW_004936482:16,804,129...16,853,539 JBrowse link
G Pdgfrb platelet derived growth factor receptor beta enables ISO (PMID:2536956)
(PMID:2554309), (PMID:2850496)		 BHF-UCL
UniProt		 PMID:2536956 PMID:2554309 PMID:2850496 NCBI chrNW_004936504:4,762,251...4,799,789 JBrowse link
transforming growth factor beta binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 enables ISO (MGI:2181509|PMID:12054694)
(PMID:8242742)		 MGI
UniProt		 PMID:8242742 PMID:12054694 MGI:2181509 NCBI chrNW_004936469:20,743,195...20,811,567 JBrowse link
G Acvr2b activin A receptor type 2B NOT ISO (MGI:51043|PMID:1326537) MGI PMID:1326537 MGI:51043 NCBI chrNW_004936473:27,816,366...27,822,555 JBrowse link
G Acvrl1 activin A receptor like type 1 enables ISO (PMID:8242742) UniProt PMID:8242742 NCBI chrNW_004936512:9,364,551...9,379,131 JBrowse link
G Agrn agrin ISO RGD PMID:20505824 RGD:8549766 NCBI chrNW_004936737:2,010,647...2,041,401 JBrowse link
G Cd109 CD109 molecule enables ISO (PMID:16754747) UniProt PMID:16754747 NCBI chrNW_004936859:467,958...595,337 JBrowse link
G Cd36 CD36 molecule enables ISO PMID:10487979 BHF-UCL PMID:10487979 RGD:2317966 NCBI chrNW_004936810:791,823...838,303 JBrowse link
G Eng endoglin contributes_to
enables		 ISO (PMID:9872992)
(PMID:1326540), (PMID:8370410)
(MGI:66318|PMID:8194490)		 BHF-UCL PMID:1326540 PMID:8194490 PMID:8370410 PMID:9872992 MGI:66318 NCBI chrNW_004936487:15,467,165...15,499,180 JBrowse link
G Hyal2 hyaluronidase 2 ISO (MGI:3851310|PMID:19366691) BHF-UCL PMID:19366691 MGI:3851310 NCBI chrNW_004936529:1,845,445...1,851,106 JBrowse link
G Lrrc32 leucine rich repeat containing 32 enables ISO (MGI:5920420|PMID:28912269)
(PMID:19651619)
(PMID:22278742)		 UniProt PMID:19651619 PMID:22278742 PMID:28912269 MGI:5920420 NCBI chrNW_004936498:5,305,680...5,315,580 JBrowse link
G Ltbp1 latent transforming growth factor beta binding protein 1 enables ISO (PMID:10930463), (PMID:2022183), (PMID:8617200)
(PMID:10930463), (PMID:18672106), (PMID:2022183), (PMID:8617200)		 UniProt PMID:2022183 PMID:8617200 PMID:10930463 PMID:18672106 NCBI chrNW_004936493:253,390...640,140 JBrowse link
G Ltbp3 latent transforming growth factor beta binding protein 3 enables ISO (PMID:10930463)
(PMID:10930463), (PMID:18672106)		 UniProt PMID:10930463 PMID:18672106 NCBI chrNW_004936599:3,902,903...3,918,471 JBrowse link
G Ltbp4 latent transforming growth factor beta binding protein 4 enables ISO (PMID:9660815)
(PMID:10930463)		 UniProt PMID:9660815 PMID:10930463 NCBI chrNW_004936661:2,919,444...2,945,847 JBrowse link
G Nrros negative regulator of reactive oxygen species enables ISO (MGI:6192878|PMID:29909984)
(PMID:29909984)		 UniProt PMID:29909984 MGI:6192878 NCBI chrNW_004936784:1,222,381...1,250,501 JBrowse link
G Tgfb3 transforming growth factor beta 3 enables ISO (PMID:18243111) BHF-UCL PMID:18243111 NCBI chrNW_004936488:4,986,712...5,008,728 JBrowse link
G Tgfbr1 transforming growth factor beta receptor 1 contributes_to
enables		 ISO (PMID:1333888)
(PMID:14633705)
(PMID:1326540)
(MGI:3766844|PMID:17878231)
(PMID:11157754)		 BHF-UCL
HGNC-UCL
MGI
RGD		 PMID:1326540 PMID:1333888 PMID:8272871 PMID:11157754 PMID:14633705 PMID:17878231 MGI:3766844 RGD:737663 NCBI chrNW_004936524:7,656,523...7,680,043 JBrowse link
G Tgfbr2 transforming growth factor beta receptor 2 contributes_to
enables		 ISO (PMID:11157754), (PMID:7852346)
(PMID:1333888)
(PMID:11157754), (PMID:18243111), (PMID:18453574), (PMID:7852346)
(PMID:1326540), (PMID:1333888)
(MGI:3766844|PMID:17878231)		 BHF-UCL
MGI		 PMID:1326540 PMID:1333888 PMID:7852346 PMID:11157754 PMID:17878231 PMID:18243111 PMID:18453574 MGI:3766844 NCBI chrNW_004936473:21,324,669...21,409,430 JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 enables
contributes_to		 ISO PMID:8106553
(PMID:11157754), (PMID:12958365)
(MGI:3699491|PMID:17295310)
PMID:7852346		 BHF-UCL
RGD		 PMID:1657407 PMID:1744125 PMID:7852346 PMID:8106553 PMID:11157754 PMID:12958365 PMID:17295310 MGI:3699491 RGD:1579949 RGD:2302518 RGD:729942 RGD:8553463 NCBI chrNW_004936537:7,154,125...7,340,218 JBrowse link
G Thbs1 thrombospondin 1 ISO RGD PMID:10487979 RGD:2317966 NCBI chrNW_004936471:3,064,466...3,081,125 JBrowse link
G Tsku tsukushi, small leucine rich proteoglycan ISO (MGI:5449316|PMID:22995554) UniProt PMID:22995554 MGI:5449316 NCBI chrNW_004936498:5,434,912...5,487,354 JBrowse link
G Twsg1 twisted gastrulation BMP signaling modulator 1 enables ISO (PMID:17164348) BHF-UCL PMID:17164348 NCBI chrNW_004936626:1,901,686...1,946,554 JBrowse link
G Vasn vasorin enables ISO (PMID:15247411) UniProt PMID:15247411 NCBI chrNW_004936694:128,398...138,954 JBrowse link
G Wfikkn1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 enables ISO (PMID:21054789) UniProt PMID:21054789 NCBI chrNW_004936501:371,328...375,271 JBrowse link
G Wfikkn2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 enables ISO (PMID:21054789)
(PMID:12595574)		 UniProt PMID:12595574 PMID:21054789 NCBI chrNW_004936490:10,897,390...10,903,605 JBrowse link
vascular endothelial growth factor binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdr kinase insert domain receptor enables ISO (PMID:20660291), (PMID:25825981) BHF-UCL PMID:20660291 PMID:25825981 NCBI chrNW_004936482:17,537,697...17,581,320 JBrowse link
G Nrp1 neuropilin 1 enables ISO (MGI:5562961|PMID:24401374)
(PMID:24401374)		 BHF-UCL PMID:24401374 MGI:5562961 NCBI chrNW_004936574:1,694,433...1,834,720 JBrowse link
G Pdgfra platelet derived growth factor receptor alpha enables ISO (PMID:17470632) BHF-UCL PMID:17470632 NCBI chrNW_004936482:16,804,129...16,853,539 JBrowse link
G Pdgfrb platelet derived growth factor receptor beta enables ISO (PMID:17470632) BHF-UCL PMID:17470632 NCBI chrNW_004936504:4,762,251...4,799,789 JBrowse link
G Ptn pleiotrophin ISO RGD PMID:17881084 RGD:2292001 NCBI chrNW_004936592:1,706,979...1,806,345 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 14118
    binding 13377
      protein binding 12971
        growth factor binding 121
          epidermal growth factor binding 3
          fibroblast growth factor binding 25
          hepatocyte growth factor binding 1
          insulin-like growth factor binding + 15
          interleukin-1 binding + 7
          interleukin-10 binding 1
          interleukin-11 binding 2
          interleukin-2 binding 3
          interleukin-3 binding 0
          interleukin-4 binding 0
          interleukin-5 binding 0
          interleukin-6 binding 2
          interleukin-7 binding 0
          interleukin-9 binding 1
          neuregulin binding 5
          neurotrophin binding + 10
          platelet-derived growth factor binding 11
          transforming growth factor beta binding 23
          vascular endothelial growth factor binding 5
paths to the root