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ONTOLOGY REPORT - ANNOTATIONS

Term:ISG15-specific peptidase activity
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Accession:GO:0019785 term browser browse the term
Definition:A thiol-dependent isopeptidase activity that cleaves ISG15 from a target protein to which it is conjugated.
Synonyms:exact_synonym: ISG15-specific protease activity
 xref: Reactome:R-HSA-9729725 "SARS-CoV-2 nsp3 deISGylates ISGylated IRF3";   Reactome:R-HSA-9755244 "SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1";   reactome:R-HSA-1678841 "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18";   reactome:R-HSA-5653786 "USP43 deISGylates ISG:K164,ISG:K168-PCNA"


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ISG15-specific peptidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Usp18 ubiquitin specific peptidase 18 enables ISO
IMP		 (PMID:16139798), (PMID:16382139) MGI PMID:16139798 PMID:16382139 GO_REF:0000119 MGI:4834177 NCBI chr 6:121,222,865...121,247,876
Ensembl chr 6:121,222,865...121,247,876 		JBrowse link
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  molecular_function 28831
    catalytic activity 5714
      hydrolase activity 2454
        peptidase activity 656
          cysteine-type peptidase activity 177
            ISG15-specific peptidase activity 1
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