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ONTOLOGY REPORT - ANNOTATIONS


Term:deNEDDylase activity
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Accession:GO:0019784 term browser browse the term
Definition:An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated.
Synonyms:exact_synonym: NEDD8-specific protease activity
 xref: reactome:R-HSA-5690808 "UCHL3, SENP8 cleave NEDD8";   reactome:R-HSA-8863723 "COP9 and TOR1 deneddylate STON2";   reactome:R-HSA-8956040 "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes";   reactome:R-HSA-8956045 "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex"



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deNEDDylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cops5 COP9 signalosome subunit 5 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:9,192,233...9,210,498
Ensembl chr 5:9,192,100...9,210,731
JBrowse link
G Otub1 OTU deubiquitinase, ubiquitin aldehyde binding 1 enables ISO
ISS
(PMID:18954305)
GO_REF:0000024
RGD
UniProt
PMID:18954305 GO_REF:0000024 NCBI chr 1:204,387,215...204,395,495
Ensembl chr 1:204,387,215...204,395,483
JBrowse link
G Senp8 SUMO peptidase family member, NEDD8 specific enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:60,135,446...60,148,836
Ensembl chr 8:60,121,714...60,148,928
JBrowse link
G Usp21 ubiquitin specific peptidase 21 enables ISO
ISS
IEA
(PMID:10799498)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:10799498 GO_REF:0000024 GO_REF:0000107 NCBI chr13:83,702,672...83,709,215
Ensembl chr13:83,702,631...83,708,717
JBrowse link

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Term Annotations click to browse term
  molecular_function 20893
    catalytic activity 6119
      catalytic activity, acting on a protein 2497
        peptidase activity 702
          ubiquitin-like protein peptidase activity 130
            deNEDDylase activity 4
              cysteine-type deNEDDylase activity 0
              metal-dependent deNEDDylase activity 0
paths to the root