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ONTOLOGY REPORT - ANNOTATIONS

Term:ammonia assimilation cycle
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Accession:GO:0019676 term browser browse the term
Definition:The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen.
Synonyms:exact_synonym: glutamate metabolic process via glutamine and ammonia;   glutamate metabolism via glutamine and ammonia


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ammonia assimilation cycle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASL argininosuccinate lyase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 3:16,637,481...16,646,869
Ensembl chr 3:16,637,481...16,646,867 		JBrowse link
G GLUL glutamate-ammonia ligase ISO RGD PMID:28323 RGD:2301547 NCBI chr 9:123,751,551...123,762,575
Ensembl chr 9:123,748,380...123,762,545 		JBrowse link
positive regulation of ammonia assimilation cycle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1H4 nuclear receptor subfamily 1 group H member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:83,607,222...83,732,668
Ensembl chr 5:83,604,294...83,684,604 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18944
    response to stimulus 10146
      response to nutrient levels 801
        nitrogen utilization 6
          ammonia assimilation cycle 3
            negative regulation of ammonia assimilation cycle 0
            positive regulation of ammonia assimilation cycle 1
            regulation of ammonia assimilation cycle + 1
Path 2
Term Annotations click to browse term
  biological_process 18944
    cellular process 18486
      metabolic process 11686
        small molecule metabolic process 1716
          organic acid metabolic process 917
            oxoacid metabolic process 898
              carboxylic acid metabolic process 882
                alpha-amino acid metabolic process 210
                  L-amino acid metabolic process 178
                    glutamine family amino acid metabolic process 66
                      glutamine metabolic process 18
                        ammonia assimilation cycle 3
                          negative regulation of ammonia assimilation cycle 0
                          positive regulation of ammonia assimilation cycle 1
                          regulation of ammonia assimilation cycle + 1
paths to the root