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ONTOLOGY REPORT - ANNOTATIONS

Term:ammonia assimilation cycle
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Accession:GO:0019676 term browser browse the term
Definition:The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen.
Synonyms:exact_synonym: glutamate metabolic process via glutamine and ammonia;   glutamate metabolism via glutamine and ammonia

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ammonia assimilation cycle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asl argininosuccinate lyase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004624740:8,414,664...8,423,797
Ensembl chrNW_004624740:8,414,733...8,423,777 		JBrowse link
G Glul glutamate-ammonia ligase ISO RGD PMID:28323 RGD:2301547 NCBI chrNW_004624771:2,608,779...2,618,130 JBrowse link
positive regulation of ammonia assimilation cycle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1h4 nuclear receptor subfamily 1 group H member 4 involved_in ISO (PMID:21757002) BHF-UCL PMID:21757002 NCBI chrNW_004624750:7,222,306...7,303,809
Ensembl chrNW_004624750:7,219,251...7,303,834 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17647
    response to stimulus 8948
      response to nutrient levels 757
        nitrogen utilization 5
          ammonia assimilation cycle 3
            negative regulation of ammonia assimilation cycle 0
            positive regulation of ammonia assimilation cycle 1
            regulation of ammonia assimilation cycle + 1
Path 2
Term Annotations click to browse term
  biological_process 17647
    cellular process 17219
      metabolic process 10996
        small molecule metabolic process 1630
          organic acid metabolic process 860
            oxoacid metabolic process 849
              carboxylic acid metabolic process 837
                alpha-amino acid metabolic process 206
                  L-amino acid metabolic process 172
                    glutamine family amino acid metabolic process 67
                      glutamine metabolic process 19
                        ammonia assimilation cycle 3
                          negative regulation of ammonia assimilation cycle 0
                          positive regulation of ammonia assimilation cycle 1
                          regulation of ammonia assimilation cycle + 1
paths to the root