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ONTOLOGY REPORT - ANNOTATIONS

Term:ammonia assimilation cycle
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Accession:GO:0019676 term browser browse the term
Definition:The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen.
Synonyms:exact_synonym: glutamate metabolic process via glutamine and ammonia;   glutamate metabolism via glutamine and ammonia

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ammonia assimilation cycle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASL argininosuccinate lyase acts_upstream_of_or_within ISO (PMID:12559843) MGI PMID:12559843 NCBI chr28:1,782,434...1,800,581
Ensembl chr28:1,782,553...1,802,517 		JBrowse link
G GLUL glutamate-ammonia ligase ISO RGD PMID:28323 RGD:2301547 NCBI chr25:46,988,853...46,998,112
Ensembl chr25:46,989,205...47,000,555 		JBrowse link
positive regulation of ammonia assimilation cycle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1H4 nuclear receptor subfamily 1 group H member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:95,792,428...95,877,989
Ensembl chr11:95,792,996...95,878,293 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19826
    response to stimulus 8888
      response to nutrient levels 801
        nitrogen utilization 6
          ammonia assimilation cycle 3
            negative regulation of ammonia assimilation cycle 0
            positive regulation of ammonia assimilation cycle 1
            regulation of ammonia assimilation cycle + 1
Path 2
Term Annotations click to browse term
  biological_process 19826
    cellular process 19340
      metabolic process 13108
        small molecule metabolic process 1741
          organic acid metabolic process 928
            oxoacid metabolic process 919
              carboxylic acid metabolic process 901
                alpha-amino acid metabolic process 221
                  L-amino acid metabolic process 185
                    glutamine family amino acid metabolic process 74
                      glutamine metabolic process 22
                        ammonia assimilation cycle 3
                          negative regulation of ammonia assimilation cycle 0
                          positive regulation of ammonia assimilation cycle 1
                          regulation of ammonia assimilation cycle + 1
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