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ONTOLOGY REPORT - ANNOTATIONS

Term:NAD metabolic process
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Accession:GO:0019674 term browser browse the term
Definition:The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.
Synonyms:exact_synonym: NAD metabolism;   nicotinamide adenine dinucleotide metabolic process;   nicotinamide adenine dinucleotide metabolism;   oxidized NAD metabolic process;   oxidized NAD metabolism;   oxidized nicotinamide adenine dinucleotide metabolic process;   oxidized nicotinamide adenine dinucleotide metabolism
 narrow_synonym: NAD phosphorylation and dephosphorylation


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NAD metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpd1l1 glycerol-3-phosphate dehydrogenase 1 like 1 involved_in ISO (PMID:19745168) RGD PMID:19745168 NCBI chr 8:114,591,103...114,620,771
Ensembl chr 8:114,588,487...114,620,723 		JBrowse link
G Kmo kynurenine 3-monooxygenase involved_in IDA
ISO		 PMID:1332540
(PMID:23575632), (PMID:29429898)		 RGD PMID:23575632 PMID:29429898 PMID:1332540 RGD:8554522 NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881 		JBrowse link
G Ldha lactate dehydrogenase A IDA RGD PMID:17447164 RGD:1624966 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Ldhb lactate dehydrogenase B IDA RGD PMID:17447164 RGD:1624966 NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403 		JBrowse link
G Mdh1 malate dehydrogenase 1 IDA RGD PMID:17447164 RGD:1624966 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925 		JBrowse link
G Nadk NAD kinase involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:166,145,708...166,176,328
Ensembl chr 5:166,145,481...166,176,322 		JBrowse link
G Nadk2 NAD kinase 2, mitochondrial involved_in ISO
IBA
ISS
IEA		 (PMID:23212377)
PMID:21873635
GO_REF:0000024
GO_REF:0000104		 RGD
UniProt		 PMID:23212377 PMID:21873635 GO_REF:0000024 GO_REF:0000104, RGD:13792537 NCBI chr 2:58,117,674...58,159,815
Ensembl chr 2:58,117,674...58,159,808 		JBrowse link
'de novo' NAD biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nadsyn1 NAD synthetase 1 involved_in ISO
IEA
ISS		 (PMID:31883644)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:31883644 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:198,981,559...199,009,806
Ensembl chr 1:198,981,604...199,009,869 		JBrowse link
'de novo' NAD biosynthetic process from tryptophan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afmid arylformamidase involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr10:103,046,129...103,061,718
Ensembl chr10:103,046,180...103,061,718 		JBrowse link
G Haao 3-hydroxyanthranilate 3,4-dioxygenase involved_in IEA
IBA		 GO_REF:0000104
PMID:21873635		 UniProt PMID:21873635 GO_REF:0000104, RGD:13792537 NCBI chr 6:10,845,235...10,864,863
Ensembl chr 6:10,845,771...10,864,877 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:67,430,684...67,442,459
Ensembl chr16:67,430,578...67,442,730 		JBrowse link
G Ido2 indoleamine 2,3-dioxygenase 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:67,459,158...67,498,052
Ensembl chr16:67,459,190...67,496,324 		JBrowse link
G Kmo kynurenine 3-monooxygenase involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881 		JBrowse link
G Kynu kynureninase involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488 		JBrowse link
NAD biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aspdh aspartate dehydrogenase domain containing involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:94,956,327...94,960,722
Ensembl chr 1:94,958,316...94,960,722 		JBrowse link
G Haao 3-hydroxyanthranilate 3,4-dioxygenase involved_in ISO (PMID:28792876) RGD PMID:28792876 NCBI chr 6:10,845,235...10,864,863
Ensembl chr 6:10,845,771...10,864,877 		JBrowse link
G Kynu kynureninase involved_in ISS
ISO		 GO_REF:0000024
(PMID:28792876)		 UniProt
RGD		 PMID:28792876 GO_REF:0000024 NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488 		JBrowse link
G Nadsyn1 NAD synthetase 1 involved_in IEA
IBA		 GO_REF:0000041
PMID:21873635		 UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 1:198,981,559...199,009,806
Ensembl chr 1:198,981,604...199,009,869 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO		 GO_REF:0000041
PMID:21873635
(MGI:3522067|PMID:15381699)		 UniProt
RGD		 PMID:15381699 PMID:21873635 GO_REF:0000041 MGI:3522067, RGD:13792537 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100 		JBrowse link
G Naprt nicotinate phosphoribosyltransferase involved_in IDA
IEA		 GO_REF:0000041 UniProt
RGD		 PMID:8694849 GO_REF:0000041, RGD:2289495 NCBI chr 7:107,576,645...107,580,102
Ensembl chr 7:107,576,627...107,580,102 		JBrowse link
G Nmnat1 nicotinamide nucleotide adenylyltransferase 1 involved_in
acts_upstream_of_or_within		 ISO
IEA
IBA		 (MGI:6206974|PMID:27735788)
GO_REF:0000041
PMID:21873635
(MGI:3522067|PMID:15381699), (MGI:3654729|PMID:16914673)		 RGD
UniProt		 PMID:15381699 PMID:16914673 PMID:27735788 PMID:21873635 GO_REF:0000041 MGI:3522067 MGI:3654729 MGI:6206974, RGD:13792537 NCBI chr 5:159,910,242...159,928,201
Ensembl chr 5:159,910,242...159,928,180 		JBrowse link
G Nmnat2 nicotinamide nucleotide adenylyltransferase 2 involved_in IMP
IEA
IBA		 GO_REF:0000041
PMID:21873635		 UniProt
RGD		 PMID:22449973 PMID:21873635 GO_REF:0000041, RGD:13782043, RGD:13792537 NCBI chr13:65,105,950...65,277,350
Ensembl chr13:65,105,950...65,278,484 		JBrowse link
G Nmnat3 nicotinamide nucleotide adenylyltransferase 3 involved_in
acts_upstream_of_or_within		 IBA
ISO
IEA		 PMID:21873635
(MGI:3654729|PMID:16914673)
GO_REF:0000041		 RGD
UniProt		 PMID:16914673 PMID:21873635 GO_REF:0000041 MGI:3654729, RGD:13792537 NCBI chr 8:98,892,168...99,003,912
Ensembl chr 8:98,873,398...99,020,645 		JBrowse link
G Nmrk1 nicotinamide riboside kinase 1 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 1:216,049,350...216,076,792
Ensembl chr 1:216,049,437...216,076,791 		JBrowse link
G Qprt quinolinate phosphoribosyltransferase involved_in IDA
IBA
IEA		 PMID:21873635
GO_REF:0000041		 UniProt
RGD		 PMID:8694849 PMID:21873635 GO_REF:0000041, RGD:2289495, RGD:13792537 NCBI chr 1:181,718,189...181,733,486
Ensembl chr 1:181,718,190...181,733,486 		JBrowse link
NAD catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Art2b ADP-ribosyltransferase 2b involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 1:155,956,601...155,974,252
Ensembl chr 1:155,956,603...155,974,253 		JBrowse link
G Nudt12 nudix hydrolase 12 involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
(PMID:12790796)		 RGD PMID:12790796 PMID:21873635 RGD:13792537 NCBI chr 9:98,741,627...98,755,039
Ensembl chr 9:98,742,360...98,755,039 		JBrowse link
G Nudt17 nudix hydrolase 17 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:184,241,468...184,243,960
Ensembl chr 2:184,241,468...184,243,960 		JBrowse link
G Sarm1 sterile alpha and TIR motif containing 1 involved_in ISO
IEA		 (PMID:25908823), (PMID:27671644), (PMID:28334607), (PMID:31128467), (PMID:31439792), (PMID:31439793), (PMID:32049506), (PMID:32828421), (PMID:33053563)
GO_REF:0000117
(MGI:6114587|PMID:28334607), (MGI:6206974|PMID:27735788), (MGI:6508517|PMID:32312889)		 RGD
UniProt		 PMID:25908823 PMID:27671644 PMID:27735788 PMID:28334607 PMID:31128467 More... GO_REF:0000117 MGI:6114587 MGI:6206974 MGI:6508517 NCBI chr10:63,369,456...63,393,016
Ensembl chr10:63,369,456...63,392,822 		JBrowse link
NAD salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Naprt nicotinate phosphoribosyltransferase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:107,576,645...107,580,102
Ensembl chr 7:107,576,627...107,580,102 		JBrowse link
NADH metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dlst dihydrolipoamide S-succinyltransferase IDA RGD PMID:9405249 RGD:1359804 NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296 		JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 IDA RGD PMID:12351438 RGD:2303499 NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529 		JBrowse link
G Gpd1l1 glycerol-3-phosphate dehydrogenase 1 like 1 acts_upstream_of_or_within ISO (MGI:4943631|PMID:19745168) RGD PMID:19745168 MGI:4943631 NCBI chr 8:114,591,103...114,620,771
Ensembl chr 8:114,588,487...114,620,723 		JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 IDA RGD PMID:12351438 RGD:2303499 NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901 		JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha IDA RGD PMID:938457 RGD:2306828 NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084 		JBrowse link
G Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta IDA RGD PMID:938457 RGD:2306828 NCBI chr 3:117,481,845...117,486,909
Ensembl chr 3:117,481,845...117,486,982 		JBrowse link
G Idh3g isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma IDA RGD PMID:938457 RGD:2306828 NCBI chr  X:151,515,244...151,524,175
Ensembl chr  X:151,515,247...151,524,171 		JBrowse link
G Mdh1 malate dehydrogenase 1 involved_in IDA
IEA
IBA
ISO		 GO_REF:0000107
PMID:21873635
(PMID:34547241)		 Ensembl
RGD		 PMID:34547241 PMID:12351438 PMID:21873635 GO_REF:0000107, RGD:2303499, RGD:13792537 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925 		JBrowse link
G Mdh1b malate dehydrogenase 1B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:65,120,370...65,168,008
Ensembl chr 9:65,119,029...65,167,933 		JBrowse link
G Mdh2 malate dehydrogenase 2 IDA RGD PMID:12351438 RGD:2303499 NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271 		JBrowse link
G Me1 malic enzyme 1 involved_in ISO
IEA		 (PMID:34547241)
GO_REF:0000107		 RGD
Ensembl		 PMID:34547241 GO_REF:0000107 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304 		JBrowse link
G Nudt12 nudix hydrolase 12 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:98,741,627...98,755,039
Ensembl chr 9:98,742,360...98,755,039 		JBrowse link
G Nudt13 nudix hydrolase 13 involved_in ISO (MGI:6368098|PMID:28755312) RGD PMID:28755312 MGI:6368098 NCBI chr15:4,001,787...4,022,404
Ensembl chr15:4,001,794...4,022,293 		JBrowse link
G Nudt17 nudix hydrolase 17 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:184,241,468...184,243,960
Ensembl chr 2:184,241,468...184,243,960 		JBrowse link
G Ogdh oxoglutarate dehydrogenase IDA RGD PMID:9712727 RGD:2306877 NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479 		JBrowse link
G Pc pyruvate carboxylase involved_in ISO
IEA		 (PMID:34547241)
GO_REF:0000107		 RGD
Ensembl		 PMID:34547241 GO_REF:0000107 NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380 		JBrowse link
G Vcp valosin-containing protein involved_in ISO (PMID:23498975) RGD PMID:23498975 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571 		JBrowse link
regulation of NAD metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Macroh2a1 macroH2A.1 histone involved_in ISS
ISO		 GO_REF:0000024
(MGI:6863428|PMID:28991266)		 UniProt
RGD		 PMID:28991266 GO_REF:0000024 MGI:6863428 NCBI chr17:8,479,331...8,542,071
Ensembl chr17:8,479,372...8,542,072 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19818
    metabolic process 12096
      cellular metabolic process 7496
        cellular aromatic compound metabolic process 3078
          purine-containing compound metabolic process 468
            purine nucleotide metabolic process 433
              NAD metabolic process 39
                NAD biosynthetic process + 15
                NAD catabolic process 4
                NADH metabolic process 17
                negative regulation of NAD metabolic process + 0
                positive regulation of NAD metabolic process + 0
                regulation of NAD metabolic process + 1
Path 2
Term Annotations click to browse term
  biological_process 19818
    metabolic process 12096
      organic substance metabolic process 11623
        organic cyclic compound metabolic process 3374
          nucleobase-containing compound metabolic process 2826
            nucleobase-containing small molecule metabolic process 573
              nucleoside phosphate metabolic process 500
                nucleotide metabolic process 489
                  pyridine nucleotide metabolic process 80
                    nicotinamide nucleotide metabolic process 80
                      NAD metabolic process 39
                        NAD biosynthetic process + 15
                        NAD catabolic process 4
                        NADH metabolic process 17
                        negative regulation of NAD metabolic process + 0
                        positive regulation of NAD metabolic process + 0
                        regulation of NAD metabolic process + 1
paths to the root