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ONTOLOGY REPORT - ANNOTATIONS


Term:NAD metabolic process
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Accession:GO:0019674 term browser browse the term
Definition:The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.
Synonyms:exact_synonym: NAD metabolism;   nicotinamide adenine dinucleotide metabolic process;   nicotinamide adenine dinucleotide metabolism;   oxidized NAD metabolic process;   oxidized NAD metabolism;   oxidized nicotinamide adenine dinucleotide metabolic process;   oxidized nicotinamide adenine dinucleotide metabolism
 narrow_synonym: NAD phosphorylation and dephosphorylation


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NAD metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpd1l glycerol-3-phosphate dehydrogenase 1-like ISO (PMID:19745168) RGD PMID:19745168 NCBI chr 8:122,957,570...122,987,236
Ensembl chr 8:122,954,948...122,987,191
JBrowse link
G Kmo kynurenine 3-monooxygenase IDA
IBA
ISO
PMID:1332540
PMID:21873635
(PMID:23575632), (PMID:29429898)
RGD PMID:23575632, PMID:29429898, PMID:1332540, PMID:21873635 RGD:8554522, RGD:13792537 NCBI chr13:93,684,324...93,715,378
Ensembl chr13:93,684,437...93,716,227
JBrowse link
G Ldha lactate dehydrogenase A IDA RGD PMID:17447164 RGD:1624966 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
G Ldhb lactate dehydrogenase B IDA RGD PMID:17447164 RGD:1624966 NCBI chr 4:176,701,980...176,719,999
Ensembl chr 4:176,701,983...176,720,012
JBrowse link
G Mdh1 malate dehydrogenase 1 IDA RGD PMID:17447164 RGD:1624966 NCBI chr14:106,378,349...106,393,642
Ensembl chr14:106,378,942...106,393,670
JBrowse link
G Nadk NAD kinase IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:172,984,930...173,015,505
Ensembl chr 5:172,986,291...173,015,494
JBrowse link
G Nadk2 NAD kinase 2, mitochondrial ISO
IBA
IEA
ISS
(PMID:23212377)
PMID:21873635
GO_REF:0000104
GO_REF:0000024
RGD
UniProt
PMID:23212377, PMID:21873635 GO_REF:0000024, GO_REF:0000104, RGD:13792537 NCBI chr 2:58,462,588...58,504,735
Ensembl chr 2:58,462,588...58,504,728
JBrowse link
canonical glycolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eno1 enolase 1 IDA
ISO
PMID:15041191
(PMID:29775581), (PMID:3529090)
RGD PMID:3529090, PMID:29775581, PMID:15041191 RGD:2302788 NCBI chr 5:167,288,223...167,299,610
Ensembl chr 5:167,288,223...167,299,609
JBrowse link
G Eno2 enolase 2 IDA PMID:15041191 CAFA PMID:15041191 RGD:2302788 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047
JBrowse link
G Foxk1 forkhead box K1 ISO (PMID:30700909) RGD PMID:30700909 NCBI chr12:14,183,436...14,244,634
Ensembl chr12:14,180,029...14,244,316
JBrowse link
G Foxk2 forkhead box K2 ISO (MGI:MGI:6281052|PMID:30700909) RGD PMID:30700909 MGI:MGI:6281052 NCBI chr10:110,468,905...110,518,854
Ensembl chr10:110,469,290...110,518,848
JBrowse link
G LOC100911625 gamma-enolase-like IDA PMID:15041191 CAFA PMID:15041191 RGD:2302788 NCBI chr 9:20,251,564...20,260,465
Ensembl chr 9:20,251,521...20,260,505
JBrowse link
G Pfkl phosphofructokinase, liver type IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:11,393,860...11,415,889
Ensembl chr20:11,393,877...11,415,882
JBrowse link
G Pfkm phosphofructokinase, muscle ISO
IBA
IEA
MGI:MGI:4356541 (MGI:MGI:4356361|PMID:19696889)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:19696889, PMID:21873635 GO_REF:0000107, MGI:MGI:4356361, RGD:13792537 NCBI chr 7:139,702,066...139,722,132
Ensembl chr 7:139,685,573...139,722,132
JBrowse link
G Pfkp phosphofructokinase, platelet IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:68,510,765...68,574,387
Ensembl chr17:68,511,064...68,559,471
JBrowse link
glucose catabolic process to lactate via pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ldha lactate dehydrogenase A ISO MGI:MGI:2384559 (MGI:MGI:62497|PMID:8224816) RGD PMID:8224816 MGI:MGI:62497 NCBI chr 1:102,900,288...102,909,713
Ensembl chr 1:102,900,286...102,909,707
JBrowse link
glycerophosphate shuttle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpd1 glycerol-3-phosphate dehydrogenase 1 ISO MGI:MGI:3692960 (MGI:MGI:1927687|PMID:11147825) RGD PMID:11147825 MGI:MGI:1927687 NCBI chr 7:141,368,928...141,377,931
Ensembl chr 7:141,370,491...141,377,928
JBrowse link
NADH oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldob aldolase, fructose-bisphosphate B ISO
IEA
(PMID:17576770)
GO_REF:0000107
RGD
Ensembl
PMID:17576770 GO_REF:0000107 NCBI chr 5:64,805,772...64,818,813
Ensembl chr 5:64,805,773...64,818,824
JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 IDA
IBA
ISO
PMID:21873635
MGI:MGI:3692960 (MGI:MGI:1927687|PMID:11147825)
RGD PMID:11147825, PMID:9550546, PMID:21873635 MGI:MGI:1927687, RGD:1641824, RGD:13792537 NCBI chr 7:141,368,928...141,377,931
Ensembl chr 7:141,370,491...141,377,928
JBrowse link
G Gpd1l glycerol-3-phosphate dehydrogenase 1-like NOT IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:122,957,570...122,987,236
Ensembl chr 8:122,954,948...122,987,191
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 IDA RGD PMID:29389585 RGD:25823193 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) IDA
IMP
RGD PMID:19635791, PMID:19635791 RGD:7242950, RGD:7242950 NCBI chr15:34,216,735...34,224,357
Ensembl chr15:34,216,833...34,224,193
JBrowse link
negative regulation of glucose catabolic process to lactate via pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc25a12 solute carrier family 25 member 12 IMP RGD PMID:19764902 RGD:13628741 NCBI chr 3:57,881,951...57,998,214
Ensembl chr 3:57,882,370...57,957,346
JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase ISO (MGI:MGI:4867601|PMID:20935145) RGD PMID:20935145 MGI:MGI:4867601 NCBI chr 4:159,635,145...159,654,108
Ensembl chr 4:159,635,153...159,654,063
JBrowse link
G Tp53 tumor protein p53 ISO (MGI:MGI:4867601|PMID:20935145) RGD PMID:20935145 MGI:MGI:4867601 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
positive regulation of glucose catabolic process to lactate via pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn3 actinin alpha 3 ISO (MGI:MGI:3759354|PMID:17828264) RGD PMID:17828264 MGI:MGI:3759354 NCBI chr 1:220,120,532...220,136,460
Ensembl chr 1:220,120,533...220,136,470
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      NAD metabolic process 23
        NADH oxidation + 5
        NADH regeneration + 8
        glucose catabolic process to lactate via pyruvate + 5
        negative regulation of NAD metabolic process + 3
        positive regulation of NAD metabolic process + 1
        regulation of NAD metabolic process + 4
        sulphoglycolysis 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.