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ONTOLOGY REPORT - ANNOTATIONS

Term:NAD metabolic process
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Accession:GO:0019674 term browser browse the term
Definition:The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.
Synonyms:exact_synonym: NAD metabolism;   nicotinamide adenine dinucleotide metabolic process;   nicotinamide adenine dinucleotide metabolism;   oxidized NAD metabolic process;   oxidized NAD metabolism;   oxidized nicotinamide adenine dinucleotide metabolic process;   oxidized nicotinamide adenine dinucleotide metabolism
 narrow_synonym: NAD phosphorylation and dephosphorylation


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NAD metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpd1l glycerol-3-phosphate dehydrogenase 1-like involved_in ISO (PMID:19745168) RGD PMID:19745168 NCBI chr 8:114,591,103...114,620,771
Ensembl chr 8:114,588,487...114,620,723 		JBrowse link
G Kmo kynurenine 3-monooxygenase involved_in IDA
IBA
ISO		 PMID:1332540
PMID:21873635
(PMID:23575632), (PMID:29429898)		 RGD PMID:23575632 PMID:29429898 PMID:1332540 PMID:21873635 RGD:8554522, RGD:13792537 NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881 		JBrowse link
G Ldha lactate dehydrogenase A IDA RGD PMID:17447164 RGD:1624966 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Ldhb lactate dehydrogenase B IDA RGD PMID:17447164 RGD:1624966 NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403 		JBrowse link
G Mdh1 malate dehydrogenase 1 IDA RGD PMID:17447164 RGD:1624966 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925 		JBrowse link
G Nadk NAD kinase involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:166,145,708...166,176,328
Ensembl chr 5:166,145,481...166,176,322 		JBrowse link
G Nadk2 NAD kinase 2, mitochondrial involved_in ISO
IBA
ISS
IEA		 (PMID:23212377)
PMID:21873635
GO_REF:0000024
GO_REF:0000104		 RGD
UniProt		 PMID:23212377 PMID:21873635 GO_REF:0000024 GO_REF:0000104, RGD:13792537 NCBI chr 2:58,117,674...58,159,815
Ensembl chr 2:58,117,674...58,159,808 		JBrowse link
canonical glycolysis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldoa aldolase, fructose-bisphosphate A involved_in ISO (MGI:5819300|PMID:28049690) RGD PMID:28049690 MGI:5819300 NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182 		JBrowse link
G Eno1 enolase 1 involved_in ISO
IDA		 (PMID:29775581), (PMID:3529090)
PMID:15041191		 RGD PMID:3529090 PMID:29775581 PMID:15041191 RGD:2302788 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 		JBrowse link
G Eno2 enolase 2 involved_in IDA PMID:15041191 CAFA PMID:15041191 RGD:2302788 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980 		JBrowse link
G Eno3 enolase 3 involved_in ISO MGI:1196256 (MGI:5892183|PMID:27760309) RGD PMID:27760309 MGI:5892183 NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921 		JBrowse link
G Foxk1 forkhead box K1 acts_upstream_of ISO (PMID:30700909) RGD PMID:30700909 NCBI chr12:12,110,119...12,175,089
Ensembl chr12:12,115,950...12,175,089 		JBrowse link
G Foxk2 forkhead box K2 acts_upstream_of ISO (MGI:6281052|PMID:30700909) RGD PMID:30700909 MGI:6281052 NCBI chr10:106,542,643...106,592,569
Ensembl chr10:106,542,566...106,592,563 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase involved_in ISO (MGI:2651735|PMID:12581789)
(MGI:2651735|PMID:12581789), (MGI:6106926|PMID:28918937), (MGI:6861792|PMID:10777777)
(MGI:2651735|PMID:12581789), (MGI:6861792|PMID:10777777)		 RGD PMID:10777777 PMID:12581789 PMID:28918937 MGI:2651735 MGI:6106926 MGI:6861792 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Hk1 hexokinase 1 involved_in ISO (MGI:6861806|PMID:4275392) RGD PMID:4275392 MGI:6861806 NCBI chr20:30,230,488...30,332,161
Ensembl chr20:30,230,486...30,332,131 		JBrowse link
G Pfkl phosphofructokinase, liver type involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:10,664,285...10,686,324
Ensembl chr20:10,664,272...10,686,315 		JBrowse link
G Pfkm phosphofructokinase, muscle involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
MGI:1196256 (MGI:5819300|PMID:28049690), (MGI:5892183|PMID:27760309), (MGI:6861806|PMID:4275392)
MGI:4356541 (MGI:4356361|PMID:19696889)
PMID:21873635		 Ensembl
RGD		 PMID:4275392 PMID:19696889 PMID:27760309 PMID:28049690 PMID:21873635 GO_REF:0000107 MGI:4356361 MGI:5819300 MGI:5892183 MGI:6861806, RGD:13792537 NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192 		JBrowse link
G Pfkp phosphofructokinase, platelet involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:63,729,743...63,794,021
Ensembl chr17:63,729,780...63,794,018 		JBrowse link
G Pgam2 phosphoglycerate mutase 2 involved_in ISO (MGI:5543738|PMID:23951293) RGD PMID:23951293 MGI:5543738 NCBI chr14:80,681,796...80,683,907
Ensembl chr14:80,681,776...80,683,940 		JBrowse link
G Pgk1 phosphoglycerate kinase 1 involved_in ISO MGI:3780541 (MGI:6857632|PMID:30174313) RGD PMID:30174313 MGI:6857632 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418 		JBrowse link
G Pkm pyruvate kinase M1/2 involved_in ISO (MGI:5908042|PMID:28630053) RGD PMID:28630053 MGI:5908042 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Tpi1 triosephosphate isomerase 1 involved_in ISO MGI:3780541 (MGI:6857632|PMID:30174313) RGD PMID:30174313 MGI:6857632 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541 		JBrowse link
glucose catabolic process to lactate via pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ldha lactate dehydrogenase A acts_upstream_of_or_within ISO MGI:2384559 (MGI:62497|PMID:8224816) RGD PMID:8224816 MGI:62497 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase acts_upstream_of ISO (MGI:4867601|PMID:20935145) RGD PMID:20935145 MGI:4867601 NCBI chr 4:159,927,138...159,946,094
Ensembl chr 4:159,927,139...159,946,029 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of ISO (MGI:4867601|PMID:20935145) RGD PMID:20935145 MGI:4867601 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
glycerophosphate shuttle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpd1 glycerol-3-phosphate dehydrogenase 1 acts_upstream_of_or_within ISO MGI:3692960 (MGI:1927687|PMID:11147825) RGD PMID:11147825 MGI:1927687 NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529 		JBrowse link
NADH oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldob aldolase, fructose-bisphosphate B involved_in ISO
IEA		 (PMID:17576770)
GO_REF:0000107		 RGD
Ensembl		 PMID:17576770 GO_REF:0000107 NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116 		JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 acts_upstream_of_or_within
involved_in		 IDA
ISO
IBA		 MGI:3692960 (MGI:1927687|PMID:11147825)
PMID:21873635		 RGD PMID:11147825 PMID:9550546 PMID:21873635 MGI:1927687, RGD:1641824, RGD:13792537 NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529 		JBrowse link
G Gpd1l glycerol-3-phosphate dehydrogenase 1-like NOT|involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:114,591,103...114,620,771
Ensembl chr 8:114,588,487...114,620,723 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 IDA RGD PMID:29389585 RGD:25823193 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) IDA
IMP		 RGD PMID:19635791 PMID:19635791 RGD:7242950, RGD:7242950 NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283 		JBrowse link
negative regulation of glucose catabolic process to lactate via pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc25a12 solute carrier family 25 member 12 IMP RGD PMID:19764902 RGD:13628741 NCBI chr 3:56,098,080...56,192,188
Ensembl chr 3:56,097,269...56,192,100 		JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase acts_upstream_of_or_within ISO (MGI:4867601|PMID:20935145) RGD PMID:20935145 MGI:4867601 NCBI chr 4:159,927,138...159,946,094
Ensembl chr 4:159,927,139...159,946,029 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within ISO (MGI:4867601|PMID:20935145) RGD PMID:20935145 MGI:4867601 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
positive regulation of glucose catabolic process to lactate via pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn3 actinin alpha 3 involved_in ISO (MGI:3759354|PMID:17828264) RGD PMID:17828264 MGI:3759354 NCBI chr 1:202,159,081...202,175,012
Ensembl chr 1:202,159,082...202,175,012 		JBrowse link
G Mir210 microRNA 210 involved_in ISO (PMID:20436681) RGD PMID:20436681 NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18734
    metabolic process 11458
      NAD metabolic process 31
        NADH oxidation + 5
        NADH regeneration + 15
        glucose catabolic process to lactate via pyruvate + 6
        negative regulation of NAD metabolic process + 3
        positive regulation of NAD metabolic process + 2
        regulation of NAD metabolic process + 5
        sulphoglycolysis 0
paths to the root