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ONTOLOGY REPORT - ANNOTATIONS


Term:reductive tricarboxylic acid cycle
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Accession:GO:0019643 term browser browse the term
Definition:A pathway leading to the fixation of two molecules of CO2 and the production of one molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes that allow the cycle to run in reverse: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and fumarate reductase. 2-oxoglutarate:ferredoxin oxidoreductase catalyzes the carboxylation of succinyl-CoA to 2-oxoglutarate, ATP citrate lyase the ATP-dependent cleavage of citrate to acetyl-CoA and oxaloacetate, and fumarate reductase the reduction of fumarate forming succinate.
Synonyms:exact_synonym: reductive Kreb's cycle;   reductive TCA cycle;   reductive carboxylate cycle;   reductive carboxylic acid cycle;   reductive citric acid pathway
 alt_id: GO:0019644
 xref: MetaCyc:P23-PWY;   MetaCyc:REDCITCYC


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  biological_process 12029
    metabolic process 7594
      primary metabolic process 6705
        tricarboxylic acid cycle 13
          reductive tricarboxylic acid cycle 0
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Term Annotations click to browse term
  biological_process 12029
    metabolic process 7594
      cellular metabolic process 6989
        generation of precursor metabolites and energy 308
          energy derivation by oxidation of organic compounds 185
            cellular respiration 106
              aerobic respiration 36
                tricarboxylic acid cycle 13
                  reductive tricarboxylic acid cycle 0
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