Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:reductive tricarboxylic acid cycle
go back to main search page
Accession:GO:0019643 term browser browse the term
Definition:A pathway leading to the fixation of two molecules of CO2 and the production of one molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes that allow the cycle to run in reverse: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and fumarate reductase. 2-oxoglutarate:ferredoxin oxidoreductase catalyzes the carboxylation of succinyl-CoA to 2-oxoglutarate, ATP citrate lyase the ATP-dependent cleavage of citrate to acetyl-CoA and oxaloacetate, and fumarate reductase the reduction of fumarate forming succinate.
Synonyms:exact_synonym: reductive Kreb's cycle;   reductive TCA cycle;   reductive carboxylate cycle;   reductive carboxylic acid cycle;   reductive citric acid pathway
 alt_id: GO:0019644
 xref: MetaCyc:P23-PWY;   MetaCyc:REDCITCYC


show annotations for term's descendants           Sort by:
 

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18677
    metabolic process 12128
      primary metabolic process 10875
        tricarboxylic acid cycle 36
          reductive tricarboxylic acid cycle 0
Path 2
Term Annotations click to browse term
  biological_process 18677
    metabolic process 12128
      cellular metabolic process 11176
        generation of precursor metabolites and energy 573
          energy derivation by oxidation of organic compounds 308
            cellular respiration 204
              aerobic respiration 91
                tricarboxylic acid cycle 36
                  reductive tricarboxylic acid cycle 0
paths to the root