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ONTOLOGY REPORT - ANNOTATIONS


Term:4-hydroxyproline metabolic process
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Accession:GO:0019471 term browser browse the term
Definition:The chemical reactions and pathways involving 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. The presence of hydroxyproline is essential to produce stable triple helical tropocollagen, hence the problems caused by ascorbate deficiency in scurvy. This unusual amino acid is also present in considerable amounts in the major glycoprotein of primary plant cell walls.
Synonyms:exact_synonym: 4-hydroxyproline metabolism


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4-hydroxyproline catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hoga1 4-hydroxy-2-oxoglutarate aldolase 1 ISO (PMID:21998747) RGD PMID:21998747 NCBI chr 1:261,291,742...261,319,743
Ensembl chr 1:261,291,870...261,318,984
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  biological_process 20027
    metabolic process 12278
      cellular metabolic process 11085
        cellular modified amino acid metabolic process 194
          4-hydroxyproline metabolic process 1
            4-hydroxyproline biosynthetic process 0
            4-hydroxyproline catabolic process 1
Path 2
Term Annotations click to browse term
  biological_process 20027
    cellular process 18798
      cellular metabolic process 11085
        organic acid metabolic process 1095
          oxoacid metabolic process 1066
            carboxylic acid metabolic process 1009
              cellular amino acid metabolic process 276
                alpha-amino acid metabolic process 201
                  4-hydroxyproline metabolic process 1
                    4-hydroxyproline biosynthetic process 0
                    4-hydroxyproline catabolic process 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.