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ONTOLOGY REPORT - ANNOTATIONS


Term:leukotriene biosynthetic process
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Accession:GO:0019370 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
Synonyms:exact_synonym: leukotriene anabolism;   leukotriene biosynthesis;   leukotriene formation;   leukotriene synthesis
 xref: Wikipedia:Leukotriene#Leukotriene_synthesis



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leukotriene biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase acts_upstream_of_or_within
involved_in
TAS
ISO
ISS
(PMID:19075240)
(MGI:1933116|PMID:7809134)
GO_REF:0000024
(PMID:21233389), (PMID:24893149)
RGD
UniProt
PMID:7809134 PMID:19075240 PMID:21233389 PMID:24893149 PMID:3417684 GO_REF:0000024 MGI:1933116, RGD:632194 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
MGI:2156546 (PMID:19075240), (PMID:9091580)
GO_REF:0000033
(PMID:2300173)
RGD
GO_Central
PMID:2300173 PMID:9091580 PMID:19075240 PMID:2300173 PMID:19075240 GO_REF:0000033, RGD:69749, RGD:2313889 NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986
JBrowse link
G Fcer1a Fc epsilon receptor Ia acts_upstream_of_or_within ISO (PMID:9000133) RGD PMID:9000133 NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351
JBrowse link
G Lta4h leukotriene A4 hydrolase involved_in ISO
IBA
ISS
(PMID:11675384), (PMID:15078870), (PMID:9774412)
GO_REF:0000033
GO_REF:0000024
RGD
GO_Central
UniProt
PMID:9774412 PMID:11675384 PMID:15078870 GO_REF:0000024 GO_REF:0000033 NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600
JBrowse link
G Ltc4s leukotriene C4 synthase involved_in TAS
IEA
IBA
IDA
GO_REF:0000104
GO_REF:0000033
UniProt
GO_Central
RGD
PMID:12767051 PMID:14637132 GO_REF:0000033 GO_REF:0000104, RGD:724432, RGD:2302289 NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 involved_in ISO
IBA
(PMID:23409838), (PMID:8703034), (PMID:9092565)
GO_REF:0000033
RGD
GO_Central
PMID:8703034 PMID:9092565 PMID:23409838 GO_REF:0000033 NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828
JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 involved_in ISO (PMID:9278457) RGD PMID:9278457 NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411
JBrowse link
G Pla2g1b phospholipase A2 group IB involved_in ISO (PMID:16005851) RGD PMID:16005851 NCBI chr12:41,142,193...41,151,967
Ensembl chr12:41,142,200...41,153,226
JBrowse link
G Pla2g4a phospholipase A2 group 4A involved_in ISO
IEA
(PMID:18451993)
GO_REF:0000043
GO_REF:0000107
(MGI:1100763|PMID:9403693)
RGD
UniProt
Ensembl
PMID:9403693 PMID:18451993 GO_REF:0000043 GO_REF:0000107 MGI:1100763 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Pla2g5 phospholipase A2, group V involved_in IDA
IEA
ISO
GO_REF:0000107
(PMID:20432503)
Ensembl
RGD
PMID:20432503 PMID:11106649 GO_REF:0000107, RGD:2303037 NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658
JBrowse link
G Prg3 proteoglycan 3, pro eosinophil major basic protein 2 involved_in ISO (PMID:10318872) RGD PMID:10318872 NCBI chr 3:70,071,970...70,078,103
Ensembl chr 3:70,072,497...70,078,102
JBrowse link
G Syk spleen associated tyrosine kinase involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2384078 (PMID:9000133)
Ensembl
RGD
PMID:9000133 GO_REF:0000107 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410
JBrowse link
leukotriene A4 biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:24282679), (PMID:31664810)
(MGI:6392995|PMID:31642348)
UniProt
Ensembl
RGD
PMID:24282679 PMID:31642348 PMID:31664810 GO_REF:0000024 GO_REF:0000107 MGI:6392995 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
leukotriene D4 biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ggt1 gamma-glutamyltransferase 1 involved_in ISO (PMID:14754911), (PMID:21447318) RGD PMID:14754911 PMID:21447318 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Ggt5 gamma-glutamyltransferase 5 involved_in
acts_upstream_of_or_within
ISO
IBA
IEA
ISS
(PMID:1676842), (PMID:21447318)
MGI:2182354 (PMID:12163373), (PMID:9774450)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024
RGD
GO_Central
Ensembl
UniProt
PMID:1676842 PMID:9774450 PMID:12163373 PMID:21447318 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr20:13,043,255...13,071,523
Ensembl chr20:13,043,257...13,071,450
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19872
    cellular process 18312
      cellular metabolic process 9669
        organic acid metabolic process 1025
          organic acid biosynthetic process 326
            carboxylic acid biosynthetic process 322
              icosanoid biosynthetic process 59
                leukotriene biosynthetic process 14
                  leukotriene A4 biosynthetic process 1
                  leukotriene B4 biosynthetic process 0
                  leukotriene D4 biosynthetic process 2
Path 2
Term Annotations click to browse term
  biological_process 19872
    metabolic process 11602
      cellular metabolic process 9669
        organic acid metabolic process 1025
          oxoacid metabolic process 1014
            carboxylic acid metabolic process 999
              icosanoid metabolic process 143
                leukotriene metabolic process 30
                  leukotriene biosynthetic process 14
                    leukotriene A4 biosynthetic process 1
                    leukotriene B4 biosynthetic process 0
                    leukotriene D4 biosynthetic process 2
paths to the root