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ONTOLOGY REPORT - ANNOTATIONS

Term:leukotriene biosynthetic process
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Accession:GO:0019370 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
Synonyms:exact_synonym: leukotriene anabolism;   leukotriene biosynthesis;   leukotriene formation;   leukotriene synthesis
 xref: Wikipedia:Leukotriene#Leukotriene_synthesis


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leukotriene biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase acts_upstream_of_or_within
involved_in		 TAS
ISO
ISS		 (PMID:19075240)
(MGI:1933116|PMID:7809134)
GO_REF:0000024
(PMID:21233389), (PMID:24893149)		 RGD
UniProt		 PMID:7809134 PMID:19075240 PMID:21233389 PMID:24893149 PMID:3417684 GO_REF:0000024 MGI:1933116, RGD:632194 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein acts_upstream_of_or_within
involved_in		 IDA
ISO
IBA		 MGI:2156546 (PMID:19075240), (PMID:9091580)
GO_REF:0000033
(PMID:2300173)		 RGD
GO_Central		 PMID:2300173 PMID:9091580 PMID:19075240 PMID:2300173 PMID:19075240 GO_REF:0000033, RGD:69749, RGD:2313889 NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986 		JBrowse link
G Fcer1a Fc epsilon receptor Ia acts_upstream_of_or_within ISO (PMID:9000133) RGD PMID:9000133 NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351 		JBrowse link
G Lta4h leukotriene A4 hydrolase involved_in ISO
IBA
ISS		 (PMID:11675384), (PMID:15078870), (PMID:9774412)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:9774412 PMID:11675384 PMID:15078870 GO_REF:0000024 GO_REF:0000033 NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600 		JBrowse link
G Ltc4s leukotriene C4 synthase involved_in TAS
IEA
IBA
IDA		 GO_REF:0000104
GO_REF:0000033
GO_REF:0000043		 UniProt
GO_Central
RGD		 PMID:12767051 PMID:14637132 GO_REF:0000033 GO_REF:0000043 GO_REF:0000104, RGD:724432, RGD:2302289 NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651 		JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 involved_in ISO
IBA		 (PMID:23409838), (PMID:8703034), (PMID:9092565)
GO_REF:0000033		 RGD
GO_Central		 PMID:8703034 PMID:9092565 PMID:23409838 GO_REF:0000033 NCBI chr 2:135,679,524...135,715,828
Ensembl chr 2:135,693,557...135,715,828 		JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 involved_in ISO (PMID:9278457) RGD PMID:9278457 NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411 		JBrowse link
G Pla2g1b phospholipase A2 group IB involved_in ISO (PMID:16005851) RGD PMID:16005851 NCBI chr12:41,142,193...41,151,967
Ensembl chr12:41,142,200...41,153,226 		JBrowse link
G Pla2g4a phospholipase A2 group IVA involved_in ISO
IEA		 (PMID:18451993)
GO_REF:0000043
GO_REF:0000107
(MGI:1100763|PMID:9403693)		 RGD
UniProt
Ensembl		 PMID:9403693 PMID:18451993 GO_REF:0000043 GO_REF:0000107 MGI:1100763 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Pla2g5 phospholipase A2, group V involved_in IDA
IEA
ISO		 GO_REF:0000107
(PMID:20432503)		 Ensembl
RGD		 PMID:20432503 PMID:11106649 GO_REF:0000107, RGD:2303037 NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658 		JBrowse link
G Prg3 proteoglycan 3, pro eosinophil major basic protein 2 involved_in ISO (PMID:10318872) RGD PMID:10318872 NCBI chr 3:70,071,970...70,078,103
Ensembl chr 3:70,072,497...70,078,102 		JBrowse link
G Syk spleen associated tyrosine kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2384078 (PMID:9000133)		 Ensembl
RGD		 PMID:9000133 GO_REF:0000107 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410 		JBrowse link
leukotriene A4 biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:24282679), (PMID:31664810)
(MGI:6392995|PMID:31642348)		 UniProt
Ensembl
RGD		 PMID:24282679 PMID:31642348 PMID:31664810 GO_REF:0000024 GO_REF:0000107 MGI:6392995 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
leukotriene D4 biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ggt1 gamma-glutamyltransferase 1 involved_in ISO (PMID:14754911), (PMID:21447318) RGD PMID:14754911 PMID:21447318 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Ggt5 gamma-glutamyltransferase 5 involved_in
acts_upstream_of_or_within		 ISO
IBA
IEA
ISS		 (PMID:1676842), (PMID:21447318)
MGI:2182354 (PMID:12163373), (PMID:9774450)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024		 RGD
GO_Central
Ensembl
UniProt		 PMID:1676842 PMID:9774450 PMID:12163373 PMID:21447318 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr20:13,043,255...13,071,523
Ensembl chr20:13,043,257...13,071,450 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    metabolic process 11835
      small molecule metabolic process 1952
        organic acid metabolic process 1077
          organic acid biosynthetic process 335
            carboxylic acid biosynthetic process 331
              icosanoid biosynthetic process 59
                leukotriene biosynthetic process 14
                  leukotriene A4 biosynthetic process 1
                  leukotriene B4 biosynthetic process 0
                  leukotriene D4 biosynthetic process 2
Path 2
Term Annotations click to browse term
  biological_process 20413
    metabolic process 11835
      cellular metabolic process 9901
        organic acid metabolic process 1077
          oxoacid metabolic process 1059
            carboxylic acid metabolic process 1040
              icosanoid metabolic process 145
                leukotriene metabolic process 31
                  leukotriene biosynthetic process 14
                    leukotriene A4 biosynthetic process 1
                    leukotriene B4 biosynthetic process 0
                    leukotriene D4 biosynthetic process 2
paths to the root