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ONTOLOGY REPORT - ANNOTATIONS


Term:leukotriene biosynthetic process
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Accession:GO:0019370 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.
Synonyms:exact_synonym: leukotriene anabolism;   leukotriene biosynthesis;   leukotriene formation;   leukotriene synthesis
 xref: Wikipedia:Leukotriene#Leukotriene_synthesis


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leukotriene biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase involved_in TAS
ISS
ISO
GO_REF:0000024
(PMID:21233389), (PMID:24893149)
MGI:1933120 (MGI:1933116|PMID:7809134), (MGI:3821938|PMID:19075240), (MGI:86611|PMID:9091580)
UniProt
RGD
PMID:7809134 PMID:9091580 PMID:19075240 PMID:21233389 PMID:24893149, PMID:3417684 GO_REF:0000024 MGI:1933116 MGI:3821938 MGI:86611, RGD:632194 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein involved_in IDA
ISO
IBA
(PMID:2300173)
PMID:21873635
MGI:2156546 (MGI:3821938|PMID:19075240), (MGI:86611|PMID:9091580)
RGD PMID:2300173 PMID:9091580 PMID:19075240, PMID:2300173, PMID:21873635, PMID:19075240 MGI:3821938 MGI:86611, RGD:69749, RGD:13792537, RGD:2313889 NCBI chr12:6,854,930...6,879,112
Ensembl chr12:6,854,920...6,879,154
JBrowse link
G Fcer1a Fc fragment of IgE receptor Ia ISO (MGI:85068|PMID:9000133) RGD PMID:9000133 MGI:85068 NCBI chr13:91,727,253...91,737,106
Ensembl chr13:91,730,925...91,737,053
JBrowse link
G Lta4h leukotriene A4 hydrolase involved_in ISS
ISO
IBA
GO_REF:0000024
(PMID:11675384), (PMID:15078870), (PMID:9774412)
PMID:21873635
UniProt
RGD
PMID:9774412 PMID:11675384 PMID:15078870, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 7:34,288,333...34,320,243
Ensembl chr 7:34,288,365...34,320,235
JBrowse link
G Ltc4s leukotriene C4 synthase involved_in TAS
IBA
IDA
PMID:21873635 RGD
GO_Central
PMID:12767051, PMID:21873635, PMID:21873635, PMID:14637132 RGD:724432, RGD:13792537, RGD:13792537, RGD:2302289 NCBI chr10:35,736,486...35,743,088
Ensembl chr10:35,737,664...35,739,625
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 involved_in ISO
IBA
(PMID:23409838), (PMID:8703034), (PMID:9092565)
PMID:21873635
RGD PMID:8703034 PMID:9092565 PMID:23409838, PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 2:140,708,396...140,727,381
Ensembl chr 2:140,708,397...140,727,281
JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 involved_in ISO (PMID:9278457) RGD PMID:9278457 NCBI chr13:85,601,499...85,622,392
Ensembl chr13:85,601,499...85,622,314
JBrowse link
G Pla2g1b phospholipase A2 group IB involved_in ISO (PMID:16005851) RGD PMID:16005851 NCBI chr12:46,879,346...46,890,234
Ensembl chr12:46,879,343...46,889,082
JBrowse link
G Pla2g4a phospholipase A2 group IVA involved_in ISO
IEA
(PMID:18451993)
GO_REF:0000107
(MGI:1100763|PMID:9403693)
RGD
Ensembl
PMID:9403693 PMID:18451993 GO_REF:0000107 MGI:1100763 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Pla2g5 phospholipase A2, group V involved_in IDA
ISO
(PMID:20432503) RGD PMID:20432503, PMID:11106649 RGD:2303037 NCBI chr 5:157,247,601...157,268,968
Ensembl chr 5:157,247,781...157,268,903
JBrowse link
G Prg3 proteoglycan 3, pro eosinophil major basic protein 2 involved_in ISO (PMID:10318872) RGD PMID:10318872 NCBI chr 3:72,395,194...72,401,254
Ensembl chr 3:72,395,218...72,401,318
JBrowse link
G Syk spleen associated tyrosine kinase involved_in IEA
ISO
GO_REF:0000107
MGI:2384078 (MGI:85068|PMID:9000133)
Ensembl
RGD
PMID:9000133 GO_REF:0000107 MGI:85068 NCBI chr17:12,614,311...12,669,568
Ensembl chr17:12,614,311...12,669,573
JBrowse link
leukotriene A4 biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase involved_in ISO
ISS
IEA
(PMID:24282679), (PMID:31664810)
GO_REF:0000024
GO_REF:0000107
(MGI:6392995|PMID:31642348)
RGD
UniProt
Ensembl
PMID:24282679 PMID:31642348 PMID:31664810 GO_REF:0000024 GO_REF:0000107 MGI:6392995 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
leukotriene D4 biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07044631.2 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 Ensembl chr20:13,988,442...14,001,269 JBrowse link
G Ggt1 gamma-glutamyltransferase 1 involved_in ISO (PMID:14754911), (PMID:21447318) RGD PMID:14754911 PMID:21447318 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
G Ggt5 gamma-glutamyltransferase 5 involved_in ISO
IBA
ISS
(PMID:1676842), (PMID:21447318)
PMID:21873635
GO_REF:0000024
MGI:2182354 (MGI:1306746|PMID:9774450), (MGI:2384601|PMID:12163373)
RGD
UniProt
PMID:1676842 PMID:9774450 PMID:12163373 PMID:21447318, PMID:21873635, PMID:21873635 GO_REF:0000024 MGI:1306746 MGI:2384601, RGD:13792537, RGD:13792537 NCBI chr20:13,988,444...14,001,296 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20078
    metabolic process 12140
      small molecule metabolic process 1820
        organic acid metabolic process 1016
          organic acid biosynthetic process 297
            carboxylic acid biosynthetic process 289
              icosanoid biosynthetic process 55
                leukotriene biosynthetic process 15
                  leukotriene A4 biosynthetic process 1
                  leukotriene B4 biosynthetic process 0
                  leukotriene D4 biosynthetic process 3
Path 2
Term Annotations click to browse term
  biological_process 20078
    metabolic process 12140
      cellular metabolic process 11076
        organic acid metabolic process 1016
          oxoacid metabolic process 978
            carboxylic acid metabolic process 959
              icosanoid metabolic process 138
                leukotriene metabolic process 30
                  leukotriene biosynthetic process 15
                    leukotriene A4 biosynthetic process 1
                    leukotriene B4 biosynthetic process 0
                    leukotriene D4 biosynthetic process 3
paths to the root