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ONTOLOGY REPORT - ANNOTATIONS


Term:isopentenyl diphosphate biosynthetic process, mevalonate pathway
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Accession:GO:0019287 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates.
Synonyms:exact_synonym: Ac-MVA pathway;   acetate-mevalonate pathway;   isopentenyl diphosphate anabolism, mevalonate pathway;   isopentenyl diphosphate biosynthetic process via mevalonate;   isopentenyl diphosphate formation, mevalonate pathway;   isopentenyl diphosphate synthesis, mevalonate pathway


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isopentenyl diphosphate biosynthetic process, mevalonate pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mvd mevalonate diphosphate decarboxylase ISO RGD PMID:197206 RGD:2316852 NCBI chrNW_004955541:2,578,584...2,581,823
Ensembl chrNW_004955541:2,579,074...2,581,821
JBrowse link
G Mvk mevalonate kinase ISO RGD PMID:197206 RGD:2316852 NCBI chrNW_004955455:8,933,250...8,953,883
Ensembl chrNW_004955455:8,930,125...8,953,894
JBrowse link
G Pmvk phosphomevalonate kinase ISO RGD PMID:197206 RGD:2316852 NCBI chrNW_004955545:1,421,562...1,440,038
Ensembl chrNW_004955545:1,421,562...1,440,038
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11892
    metabolic process 7610
      organic substance metabolic process 7321
        thioester metabolic process 61
          acyl-CoA metabolic process 61
            acetyl-CoA metabolic process 30
              isopentenyl diphosphate biosynthetic process, mevalonate pathway 3
                isopentenyl diphosphate biosynthetic process, mevalonate pathway involved in terpenoid biosynthetic process 0
                negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway 0
                positive regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway 0
                regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway + 0
Path 2
Term Annotations click to browse term
  biological_process 11892
    metabolic process 7610
      cellular metabolic process 7025
        cellular aromatic compound metabolic process 3735
          nucleobase-containing compound metabolic process 3563
            nucleobase-containing small molecule metabolic process 356
              nucleoside phosphate metabolic process 311
                nucleotide metabolic process 301
                  purine nucleotide metabolic process 253
                    purine ribonucleotide metabolic process 236
                      acyl-CoA metabolic process 61
                        acetyl-CoA metabolic process 30
                          isopentenyl diphosphate biosynthetic process, mevalonate pathway 3
                            isopentenyl diphosphate biosynthetic process, mevalonate pathway involved in terpenoid biosynthetic process 0
                            negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway 0
                            positive regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway 0
                            regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.