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ONTOLOGY REPORT - ANNOTATIONS


Term:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione
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Accession:GO:0019243 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step.
Synonyms:exact_synonym: D-lactate biosynthesis from methylglyoxal;   D-lactate biosynthetic process from methylglyoxal;   methylglyoxal breakdown to D-lactate;   methylglyoxal catabolism to D-lactate via S-lactoyl-glutathione;   methylglyoxal degradation to D-lactate
 related_synonym: glyoxalase system;   methylglyoxal detoxification
 xref: MetaCyc:PWY-5386



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methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gatd1 glutamine amidotransferase class 1 domain containing 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:196,504,533...196,512,561
Ensembl chr 1:196,504,833...196,512,551
JBrowse link
G Hagh hydroxyacyl glutathione hydrolase involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:13,874,883...13,889,527
Ensembl chr10:13,875,241...13,889,504
JBrowse link
G Haghl hydroxyacylglutathione hydrolase-like involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:14,804,957...14,809,495
Ensembl chr10:14,804,997...14,807,665
JBrowse link
G Pnkd PNKD metallo-beta-lactamase domain containing involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:75,868,620...75,937,126
Ensembl chr 9:75,867,468...75,937,124
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20094
    metabolic process 12347
      organic substance metabolic process 11867
        organic hydroxy compound metabolic process 577
          lactate metabolic process 24
            methylglyoxal catabolic process to lactate 5
              methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione 4
Path 2
Term Annotations click to browse term
  biological_process 20094
    metabolic process 12347
      cellular metabolic process 10465
        organic acid metabolic process 1058
          oxoacid metabolic process 1044
            carboxylic acid metabolic process 1030
              monocarboxylic acid metabolic process 703
                lactate metabolic process 24
                  methylglyoxal catabolic process to lactate 5
                    methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione 4
paths to the root