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ONTOLOGY REPORT - ANNOTATIONS


Term:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione
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Accession:GO:0019243 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step.
Synonyms:exact_synonym: D-lactate biosynthesis from methylglyoxal;   D-lactate biosynthetic process from methylglyoxal;   methylglyoxal breakdown to D-lactate;   methylglyoxal catabolism to D-lactate via S-lactoyl-glutathione;   methylglyoxal degradation to D-lactate
 related_synonym: glyoxalase system;   methylglyoxal detoxification
 xref: MetaCyc:PWY-5386


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methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hagh hydroxyacyl glutathione hydrolase JBrowse link 10 14,215,913 14,230,506 RGD:1600115
G Haghl hydroxyacylglutathione hydrolase-like JBrowse link 10 15,152,736 15,157,221 RGD:1600115
G Pnkd PNKD metallo-beta-lactamase domain containing JBrowse link 9 81,566,074 81,634,531 RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19678
    metabolic process 11953
      organic substance metabolic process 11358
        organic hydroxy compound metabolic process 529
          lactate metabolic process 20
            methylglyoxal catabolic process to lactate 4
              methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione 3
Path 2
Term Annotations click to browse term
  biological_process 19678
    metabolic process 11953
      cellular metabolic process 10781
        organic acid metabolic process 1068
          oxoacid metabolic process 1041
            carboxylic acid metabolic process 993
              monocarboxylic acid metabolic process 652
                lactate metabolic process 20
                  methylglyoxal catabolic process to lactate 4
                    methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.