Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer VCMap
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione
go back to main search page
Accession:GO:0019243 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step.
Synonyms:exact_synonym: D-lactate biosynthesis from methylglyoxal;   D-lactate biosynthetic process from methylglyoxal;   methylglyoxal breakdown to D-lactate;   methylglyoxal catabolism to D-lactate via S-lactoyl-glutathione;   methylglyoxal degradation to D-lactate
 related_synonym: glyoxalase system;   methylglyoxal detoxification
 xref: MetaCyc:PWY-5386


show annotations for term's descendants           Sort by:
 
methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gatd1 glutamine amidotransferase class 1 domain containing 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:196,504,533...196,512,561
Ensembl chr 1:196,504,833...196,512,551 		JBrowse link
G Hagh hydroxyacyl glutathione hydrolase involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:13,874,883...13,889,527
Ensembl chr10:13,875,241...13,889,504 		JBrowse link
G Haghl hydroxyacylglutathione hydrolase-like involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:14,804,957...14,809,495
Ensembl chr10:14,804,997...14,807,665 		JBrowse link
G Pnkd PNKD metallo-beta-lactamase domain containing involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:75,868,620...75,937,126
Ensembl chr 9:75,867,468...75,937,124 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20099
    metabolic process 12353
      organic substance metabolic process 11873
        organic hydroxy compound metabolic process 577
          lactate metabolic process 24
            methylglyoxal catabolic process to lactate 5
              methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione 4
Path 2
Term Annotations click to browse term
  biological_process 20099
    metabolic process 12353
      cellular metabolic process 10470
        organic acid metabolic process 1058
          oxoacid metabolic process 1044
            carboxylic acid metabolic process 1030
              monocarboxylic acid metabolic process 703
                lactate metabolic process 24
                  methylglyoxal catabolic process to lactate 5
                    methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione 4
paths to the root