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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of vasoconstriction
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Accession:GO:0019229 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels.



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regulation of vasoconstriction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr15:45,005,648...45,111,416 JBrowse link
G Adra1b adrenoceptor alpha 1B involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:28,255,025...28,373,418 JBrowse link
G Adra2a adrenoceptor alpha 2A involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:263,066,780...263,069,580 JBrowse link
G Agtr1a angiotensin II receptor, type 1a involved_in ISO (PMID:15117835) RGD PMID:15117835 NCBI chr17:34,383,397...34,435,523 JBrowse link
G Agtr1b angiotensin II receptor, type 1b involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:104,774,005...104,849,262 JBrowse link
G Asic2 acid sensing ion channel subunit 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2180111 (PMID:18296560)
Ensembl
RGD
PMID:18296560 GO_REF:0000107 NCBI chr10:65,870,592...66,940,577 JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 acts_upstream_of_or_within ISO MGI:2451291|MGI:98496 (PMID:14627611) RGD PMID:14627611 NCBI chr13:84,729,597...84,754,544 JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C acts_upstream_of_or_within ISO MGI:2389040|MGI:2674119 (PMID:14609949) RGD PMID:14609949 NCBI chr 4:151,764,138...152,379,454 JBrowse link
G Drd1 dopamine receptor D1 IMP RGD PMID:15778266 RGD:7175070 NCBI chr17:10,545,488...10,550,029 JBrowse link
G Edn1 endothelin 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr17:22,660,799...22,666,687 JBrowse link
G Edn2 endothelin 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:133,751,316...133,756,814 JBrowse link
G Edn3 endothelin 3 involved_in TAS
IEA
GO_REF:0000002 InterPro
RGD
PMID:12184995 GO_REF:0000002, RGD:1299957 NCBI chr 3:163,562,307...163,586,636 JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:38,427,169...38,431,733 JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 acts_upstream_of_or_within ISO MGI:2384510 (PMID:11481235) RGD PMID:11481235 NCBI chr 4:161,040,853...161,044,311 JBrowse link
G P2rx1 purinergic receptor P2X 1 acts_upstream_of_or_within ISO MGI:2181608 (PMID:14679185) RGD PMID:14679185 NCBI chr10:57,618,586...57,633,648 JBrowse link
G Per2 period circadian regulator 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:17404161)
UniProt
RGD
PMID:17404161 GO_REF:0000024 NCBI chr 9:99,454,828...99,497,069 JBrowse link
G Prkcq protein kinase C, theta IEP RGD PMID:16951045 RGD:1625607 NCBI chr17:72,156,215...72,288,508 JBrowse link
G Tbxa2r thromboxane A2 receptor acts_upstream_of_or_within ISO MGI:88106 (PMID:14627611) RGD PMID:14627611 NCBI chr 7:9,034,077...9,041,489 JBrowse link
negative regulation of vascular associated smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgap42 Rho GTPase activating protein 42 acts_upstream_of_or_within ISO MGI:3871380 (PMID:24335996) RGD PMID:24335996 NCBI chr 8:6,154,759...6,384,497 JBrowse link
G Dock4 dedicator of cytokinesis 4 involved_in ISO (PMID:22158624) RGD PMID:22158624 NCBI chr 6:63,240,050...63,629,772 JBrowse link
G Dock5 dedicator of cytokinesis 5 involved_in ISO (PMID:22158624) RGD PMID:22158624 NCBI chr15:41,979,728...42,158,733 JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 involved_in IMP PMID:19237536 UniProt PMID:19237536 RGD:401901238 NCBI chr10:14,850,765...14,853,046 JBrowse link
negative regulation of vasoconstriction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin involved_in ISO (PMID:11410113) RGD PMID:11410113 NCBI chr 1:174,164,178...174,182,372 JBrowse link
G Ahr aryl hydrocarbon receptor involved_in ISO (PMID:14644620) RGD PMID:14644620 NCBI chr 6:57,961,423...57,998,901 JBrowse link
G Apln apelin IMP RGD PMID:17318790 RGD:1626185 NCBI chr  X:132,058,739...132,091,518 JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 involved_in ISO (PMID:18552156) RGD PMID:18552156 NCBI chr 9:68,685,942...68,801,353 JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 IDA RGD PMID:19201996 RGD:4891967 NCBI chr19:10,233,326...10,244,856 JBrowse link
G Dusp5 dual specificity phosphatase 5 IMP RGD PMID:25397684 RGD:13446412 NCBI chr 1:262,543,774...262,557,201 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha IMP RGD PMID:21106323 RGD:5147878 NCBI chr 6:98,357,788...98,405,068 JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B IMP regulates cerebral vasospasm following subarachnoid hemorrhage RGD PMID:15381648 RGD:1626660 NCBI chr20:3,859,756...3,863,800 JBrowse link
G Itga4 integrin subunit alpha 4 involved_in ISO (PMID:35802072) RGD PMID:35802072 NCBI chr 3:84,569,487...84,646,276 JBrowse link
G Itga9 integrin subunit alpha 9 involved_in ISO (PMID:35802072) RGD PMID:35802072 NCBI chr 8:118,307,424...118,615,527 JBrowse link
G Itgb1 integrin subunit beta 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:35802072)
UniProt
RGD
PMID:35802072 GO_REF:0000024 NCBI chr19:73,602,277...73,650,271 JBrowse link
G Lep leptin IDA RGD PMID:20978518 RGD:5128573 NCBI chr 4:58,626,529...58,640,663 JBrowse link
G Mmp2 matrix metallopeptidase 2 IDA RGD PMID:19482300 RGD:2325737 NCBI chr19:30,327,643...30,355,856 JBrowse link
G Mtnr1b melatonin receptor 1B IMP RGD PMID:10199853 RGD:9588661 NCBI chr 8:12,638,219...12,652,737 JBrowse link
G Nos1 nitric oxide synthase 1 IMP RGD PMID:23640592 RGD:7257607 NCBI chr12:44,276,011...44,456,371 JBrowse link
G Svep1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:35802072)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:35802072 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:72,811,200...72,988,185 JBrowse link
positive regulation of vascular associated smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm3 cholinergic receptor, muscarinic 3 IMP RGD PMID:8428203 RGD:2303387 NCBI chr17:64,696,549...65,158,622 JBrowse link
G Mir21 microRNA 21 involved_in ISO (PMID:22158624) RGD PMID:22158624 NCBI chr10:71,902,600...71,902,691 JBrowse link
G Rhoa ras homolog family member A acts_upstream_of_or_within ISO (PMID:24335996) RGD PMID:24335996 NCBI chr 8:117,870,548...117,904,303 JBrowse link
positive regulation of vasoconstriction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase IMP RGD PMID:17615370 RGD:8693596 NCBI chr 3:35,377,587...35,480,843 JBrowse link
G Ace angiotensin I converting enzyme IMP RGD PMID:17161436 RGD:12879819 NCBI chr10:91,410,129...91,430,246 JBrowse link
G Add3 adducin 3 IMP RGD PMID:27927653 RGD:13446409 NCBI chr 1:262,152,722...262,260,504 JBrowse link
G Adra1a adrenoceptor alpha 1A involved_in IDA
IMP
PMID:19011682 RGD
BHF-UCL
PMID:15877108 PMID:22040923 PMID:19011682 RGD:1625777, RGD:5688308, RGD:5688340 NCBI chr15:45,005,648...45,111,416 JBrowse link
G Adra1d adrenoceptor alpha 1D involved_in IMP
IBA
GO_REF:0000033 GO_Central
RGD
PMID:17199872 GO_REF:0000033, RGD:5688350 NCBI chr 3:118,793,356...118,809,354 JBrowse link
G Adra2c adrenoceptor alpha 2C IMP RGD PMID:20862454 RGD:6893567 NCBI chr14:75,470,884...75,472,846 JBrowse link
G Akt1 AKT serine/threonine kinase 1 IMP RGD PMID:21532183 RGD:5509096 NCBI chr 6:137,534,810...137,555,131 JBrowse link
G Alox5 arachidonate 5-lipoxygenase IMP RGD PMID:16331105 RGD:1626151 NCBI chr 4:151,203,948...151,251,126 JBrowse link
G Avp arginine vasopressin IMP RGD PMID:18483147 RGD:2301932 NCBI chr 3:138,246,544...138,248,522 JBrowse link
G Avpr1a arginine vasopressin receptor 1A involved_in IMP
IBA
GO_REF:0000033 GO_Central
RGD
PMID:17428891 GO_REF:0000033, RGD:2300345 NCBI chr 7:59,999,743...60,003,667 JBrowse link
G Avpr1b arginine vasopressin receptor 1B involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:43,046,531...43,059,046 JBrowse link
G Avpr2 arginine vasopressin receptor 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:156,785,009...156,787,477 JBrowse link
G Casr calcium-sensing receptor IMP RGD PMID:22098336 RGD:7205678 NCBI chr11:77,738,398...77,813,639 JBrowse link
G Cav1 caveolin 1 acts_upstream_of_or_within
involved_in
IMP
ISO
IEA
MGI:2180364 (PMID:11884617)
GO_REF:0000107
RGD
Ensembl
PMID:11884617 PMID:21098487 GO_REF:0000107, RGD:6849297 NCBI chr 4:46,606,538...46,639,616 JBrowse link
G Cd38 CD38 molecule IMP RGD PMID:18524860 RGD:2307237 NCBI chr14:71,384,532...71,424,794 JBrowse link
G Chga chromogranin A IDA RGD PMID:15544843 RGD:6907046 NCBI chr 6:121,696,051...121,707,399 JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 IMP RGD PMID:9316844 RGD:2303391 NCBI chr17:64,696,549...65,158,622 JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 IMP RGD PMID:16445567 PMID:16331105 RGD:2316238, RGD:1626151 NCBI chr  X:75,734,281...75,762,873 JBrowse link
G Dbh dopamine beta-hydroxylase involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857556 (PMID:9139828)
Ensembl
RGD
PMID:9139828 GO_REF:0000107 NCBI chr 3:30,886,313...30,903,313 JBrowse link
G Egfr epidermal growth factor receptor IMP RGD PMID:22966991 RGD:7204494 NCBI chr14:95,378,626...95,551,358 JBrowse link
G F2r coagulation factor II (thrombin) receptor involved_in IDA
ISO
IEA
(PMID:21859963)
GO_REF:0000107
RGD
Ensembl
PMID:21859963 PMID:12644441 GO_REF:0000107, RGD:1582293 NCBI chr 2:26,869,343...26,885,856 JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO (PMID:24506284) RGD PMID:24506284 NCBI chr 2:28,507,003...28,519,954 JBrowse link
G Faah fatty acid amide hydrolase IMP RGD PMID:17245358 RGD:1625725 NCBI chr 5:134,716,545...134,735,396 JBrowse link
G Fga fibrinogen alpha chain involved_in ISO (PMID:15739255) RGD PMID:15739255 NCBI chr 2:170,672,169...170,679,572 JBrowse link
G Fgb fibrinogen beta chain involved_in ISO (PMID:15739255) RGD PMID:15739255 NCBI chr 2:168,394,901...168,402,863 JBrowse link
G Fgg fibrinogen gamma chain involved_in ISO (PMID:15739255) RGD PMID:15739255 NCBI chr 2:168,354,880...168,362,325 JBrowse link
G Gja1 gap junction protein, alpha 1 IMP RGD PMID:21414209 RGD:7207411 NCBI chr20:36,302,490...36,315,010 JBrowse link
G Gja5 gap junction protein, alpha 5 IMP RGD PMID:21414209 RGD:7207411 NCBI chr 2:187,291,227...187,310,770 JBrowse link
G Grk2 G protein-coupled receptor kinase 2 IMP RGD PMID:28882814 RGD:13506839 NCBI chr 1:211,010,259...211,031,013 JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase IMP RGD PMID:19221211 RGD:2316498 NCBI chr 2:29,732,163...29,754,276 JBrowse link
G Hrh1 histamine receptor H 1 involved_in IMP
IEA
GO_REF:0000002 InterPro
RGD
PMID:17169617 GO_REF:0000002, RGD:1642309 NCBI chr 4:149,120,511...149,204,267 JBrowse link
G Hrh2 histamine receptor H 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr17:10,366,004...10,407,791 JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A IMP RGD PMID:16527989 PMID:18358471 RGD:1582161, RGD:401938603 NCBI chr15:56,360,647...56,428,703 JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C IMP RGD PMID:15118345 RGD:1625008 NCBI chr  X:115,453,190...115,682,325 JBrowse link
G Icam1 intercellular adhesion molecule 1 IMP RGD PMID:12296653 RGD:4145431 NCBI chr 8:27,829,688...27,841,618 JBrowse link
G Klk1c9 kallikrein 1-related peptidase C9 IDA RGD PMID:1900513 RGD:1302426 NCBI chr 1:94,597,359...94,601,245 JBrowse link
G Mgll monoglyceride lipase IMP RGD PMID:17245358 RGD:1625725 NCBI chr 4:122,749,436...122,851,440 JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I involved_in ISO (PMID:24506284) RGD PMID:24506284
G Mt-co2 mitochondrially encoded cytochrome c oxidase II involved_in ISO (PMID:24506284) RGD PMID:24506284
G Npy1r neuropeptide Y receptor Y1 IMP RGD PMID:9802404 RGD:1642323 NCBI chr16:27,804,416...27,814,070 JBrowse link
G Oxtr oxytocin receptor involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:147,154,374...147,171,723 JBrowse link
G Pde5a phosphodiesterase 5A IMP RGD PMID:19542492 RGD:2314461 NCBI chr 2:210,858,515...211,003,480 JBrowse link
G Ptger3 prostaglandin E receptor 3 IMP RGD PMID:10747002 RGD:10043337 NCBI chr 2:246,606,131...246,750,970 JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 IMP RGD PMID:17245358 PMID:18456673 RGD:1625725, RGD:2300248 NCBI chr 3:39,981,419...40,002,993 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IMP RGD PMID:17245358 PMID:18456673 RGD:1625725, RGD:2300248 NCBI chr13:64,714,063...64,722,320 JBrowse link
G Rbfox2 RNA binding fox-1 homolog 2 IMP RGD PMID:28993448 RGD:329848961 NCBI chr 7:108,810,627...109,054,420 JBrowse link
G Rhoa ras homolog family member A IEP RGD PMID:17468135 RGD:1642958 NCBI chr 8:117,870,548...117,904,303 JBrowse link
G Shc1 SHC adaptor protein 1 IMP RGD PMID:16242150 RGD:1643184 NCBI chr 2:177,135,649...177,147,257 JBrowse link
G Smtnl1 smoothelin-like 1 acts_upstream_of_or_within
involved_in
ISO MGI:3796616 (PMID:18310078)
(PMID:20634291)
RGD PMID:18310078 PMID:20634291 NCBI chr 3:69,889,010...69,901,096 JBrowse link
G Tacr1 tachykinin receptor 1 IMP RGD PMID:18602450 RGD:2304265 NCBI chr 4:116,478,617...116,647,492 JBrowse link
G Tbxa2r thromboxane A2 receptor involved_in IMP
IBA
GO_REF:0000033 GO_Central
RGD
PMID:16905600 PMID:10513923 GO_REF:0000033, RGD:1601433, RGD:11059603 NCBI chr 7:9,034,077...9,041,489 JBrowse link
G Tbxas1 thromboxane A synthase 1 IMP RGD PMID:9370383 RGD:1601472 NCBI chr 4:67,664,963...67,837,096 JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 IMP RGD PMID:20610768 PMID:15472118 RGD:9999443, RGD:10003027 NCBI chr 1:95,781,805...95,812,095 JBrowse link
G Uts2r urotensin 2 receptor IMP RGD PMID:15554454 RGD:2306845 NCBI chr10:106,438,092...106,439,252 JBrowse link
G Wdr35 WD repeat domain 35 IDA RGD PMID:18671723 RGD:11553926 NCBI chr 6:31,771,315...31,831,450 JBrowse link
regulation of vascular associated smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2b adrenoceptor alpha 2B IMP RGD PMID:18054907 RGD:2313547 NCBI chr 3:114,585,174...114,589,220 JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:24805951)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:24805951 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:35,622,267...35,731,904 JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 IMP inhibition decreases both calcium-stimulated and unstimulated myogenic tone in middle cerebral arteries (p<0.001) RGD PMID:10198244 RGD:2293329 NCBI chr 8:73,578,747...73,650,184 JBrowse link
G P2rx1 purinergic receptor P2X 1 acts_upstream_of_or_within ISO MGI:2181608 (PMID:16920810) RGD PMID:16920810 NCBI chr10:57,618,586...57,633,648 JBrowse link
G Zdhhc21 zinc finger DHHC-type palmitoyltransferase 21 involved_in ISO (PMID:26715683) RGD PMID:26715683 NCBI chr 5:97,227,621...97,286,866 JBrowse link
regulation of vasoconstriction by circulating norepinephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snta1 syntrophin, alpha 1 acts_upstream_of_or_within ISO MGI:2179769 (PMID:12600881) RGD PMID:12600881 NCBI chr 3:163,336,509...163,366,954 JBrowse link
regulation of vein smooth muscle contraction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 enables IDA salbutamol, isoproterenol, clenbuterol, norepinephrine RGD PMID:6289140 RGD:2301944 NCBI chr18:57,912,760...57,914,802 JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 IMP RGD PMID:31125290 RGD:14696717 NCBI chr 1:243,049,064...243,173,636 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20534
    multicellular organismal process 8969
      regulation of multicellular organismal process 3340
        regulation of system process 683
          regulation of blood circulation 290
            regulation of vasoconstriction 99
              negative regulation of vasoconstriction + 20
              positive regulation of vasoconstriction + 56
              regulation of vascular associated smooth muscle contraction + 14
              regulation of vasoconstriction by epinephrine + 0
              regulation of vasoconstriction by norepinephrine + 1
Path 2
Term Annotations click to browse term
  biological_process 20534
    biological regulation 13821
      regulation of biological quality 3448
        regulation of anatomical structure size 617
          regulation of tube size 213
            regulation of tube diameter 212
              blood vessel diameter maintenance 212
                vasoconstriction 126
                  regulation of vasoconstriction 99
                    negative regulation of vasoconstriction + 20
                    positive regulation of vasoconstriction + 56
                    regulation of vascular associated smooth muscle contraction + 14
                    regulation of vasoconstriction by epinephrine + 0
                    regulation of vasoconstriction by norepinephrine + 1
paths to the root