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ONTOLOGY REPORT - ANNOTATIONS


Term:nonribosomal peptide biosynthetic process
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Accession:GO:0019184 term browser browse the term
Definition:The biosynthetic process in which peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione.
Synonyms:exact_synonym: non-ribosomal peptide biosynthesis;   non-ribosomal peptide biosynthetic process;   non-ribosomal peptide formation;   non-ribosomal peptide synthesis;   nonribosomal peptide anabolism;   nonribosomal peptide biosynthesis;   nonribosomal peptide formation;   nonribosomal peptide synthesis
 related_synonym: nonribosomal peptide synthetase


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amino acid activation for nonribosomal peptide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aasdh aminoadipate-semialdehyde dehydrogenase acts_upstream_of_or_within ISO (MGI:5630050|PMID:24467666) MGI PMID:24467666 MGI:5630050 NCBI chrNW_004936482:18,558,789...18,591,709 JBrowse link
glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclc glutamate-cysteine ligase catalytic subunit acts_upstream_of_or_within
involved_in
ISO (MGI:3607629|PMID:16081425)
(MGI:1858542|PMID:10805773)
(PMID:10395918), (PMID:8104187), (PMID:9675072)
(PMID:12663448)
RGD
MGI
UniProt
PMID:8104187 PMID:9675072 PMID:10395918 PMID:10805773 PMID:12663448 More... MGI:1858542 MGI:3607629 RGD:1582661 NCBI chrNW_004936476:7,371,270...7,418,756 JBrowse link
G Ggt1 gamma-glutamyltransferase 1 involved_in ISO (MGI:5294309|PMID:12468440) UniProt PMID:12468440 MGI:5294309 NCBI chrNW_004936619:762,278...791,610 JBrowse link
G Gss glutathione synthetase ISO RGD PMID:10964706 RGD:1599340 NCBI chrNW_004936561:5,765,637...5,793,951 JBrowse link
G Hagh hydroxyacylglutathione hydrolase involved_in ISO (PMID:8550579) UniProt PMID:8550579 NCBI chrNW_004936694:2,181,475...2,200,469 JBrowse link
G LOC101977655 glutamate--cysteine ligase regulatory subunit acts_upstream_of_or_within
involved_in
ISO (MGI:3607629|PMID:16081425)
(PMID:12081989)
(PMID:10395918), (PMID:9675072)
RGD
MGI
UniProt
PMID:9675072 PMID:10395918 PMID:12081989 PMID:16081425 PMID:16183645 MGI:3607629 RGD:1582661 NCBI chrNW_004936537:5,356,914...5,378,998 JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 involved_in ISO (PMID:8703034) UniProt PMID:8703034 NCBI chrNW_004936535:7,995,185...8,015,463 JBrowse link
G Slc1a1 solute carrier family 1 member 1 involved_in ISO (MGI:6478075|PMID:12614333) MGI PMID:12614333 MGI:6478075 NCBI chrNW_004936503:613,250...690,555 JBrowse link
G Slc1a2 solute carrier family 1 member 2 involved_in ISO (MGI:6478075|PMID:12614333) MGI PMID:12614333 MGI:6478075 NCBI chrNW_004936533:2,779,650...2,918,640 JBrowse link
positive regulation of glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (MGI:5616326|PMID:14978030) ParkinsonsUK-UCL PMID:14978030 MGI:5616326 NCBI chrNW_004936712:413,602...454,443 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 involved_in ISO (MGI:5616326|PMID:14978030) ParkinsonsUK-UCL PMID:14978030 MGI:5616326 NCBI chrNW_004936509:6,589,967...6,621,171 JBrowse link
regulation of glutathione biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc7a11 solute carrier family 7 member 11 acts_upstream_of_or_within ISO (MGI:3588610|PMID:16037214) MGI PMID:16037214 MGI:3588610 NCBI chrNW_004936535:9,177,305...9,242,743 JBrowse link
siderophore biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdh2 3-hydroxybutyrate dehydrogenase 2 involved_in ISO (MGI:4820913|PMID:20550936) UniProt PMID:20550936 MGI:4820913 NCBI chrNW_004936520:278,467...304,525 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12173
    metabolic process 7652
      biosynthetic process 3941
        organic substance biosynthetic process 3861
          organonitrogen compound biosynthetic process 1060
            peptide biosynthetic process 403
              nonribosomal peptide biosynthetic process 13
                amino acid activation for nonribosomal peptide biosynthetic process + 1
                glutathione biosynthetic process + 11
                siderophore biosynthetic process + 1
                vancomycin biosynthetic process 0
Path 2
Term Annotations click to browse term
  biological_process 12173
    metabolic process 7652
      nitrogen compound metabolic process 6404
        cellular nitrogen compound metabolic process 4138
          cellular amide metabolic process 707
            peptide metabolic process 507
              peptide biosynthetic process 403
                nonribosomal peptide biosynthetic process 13
                  amino acid activation for nonribosomal peptide biosynthetic process + 1
                  glutathione biosynthetic process + 11
                  siderophore biosynthetic process + 1
                  vancomycin biosynthetic process 0
paths to the root