deoxyhypusine monooxygenase activity - Ontology Report

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Term:	deoxyhypusine monooxygenase activity	go back to main search page
Accession:	GO:0019135	browse the term
Definition:	Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O.
Synonyms:	exact_synonym:	deoxyhypusine hydroxylase activity
	related_synonym:	DOHH activity; deoxyhypusine dioxygenase activity; deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)
	xref:	EC:1.14.99.29; MetaCyc:DEOXYHYPUSINE-MONOOXYGENASE-RXN; RHEA:14101; reactome:R-HSA-204662 "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A"

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Genes (1)

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Dohh

deoxyhypusine hydroxylase

enables

(PMID:16371467), (PMID:16533814), (PMID:19706422)
GO_REF:0000024
GO_REF:0000104
(PMID:24832488)
GO_REF:0000033

GO_REF:0000024 GO_REF:0000033 GO_REF:0000104

NCBI chr 7:8,321,466...8,326,305
Ensembl chr 7:8,321,466...8,326,289

Term paths to the root

Path 1
Term	Annotations
molecular_function	20634
catalytic activity	6032
catalytic activity, acting on a protein	2509
deoxyhypusine monooxygenase activity	1
Path 2
Term	Annotations
molecular_function	20634
catalytic activity	6032
oxidoreductase activity	854
monooxygenase activity	159
deoxyhypusine monooxygenase activity	1

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