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ONTOLOGY REPORT - ANNOTATIONS


Term:SCF ubiquitin ligase complex
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Accession:GO:0019005 term browser browse the term
Definition:A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
Synonyms:exact_synonym: CDL1 complex;   CRL1 complex;   Cul1-RING ubiquitin ligase complex;   SCF complex;   Skp1/Cul1/F-box protein complex;   cullin-RING ligase 1
 narrow_synonym: SCF complex substrate recognition subunit
 xref: Wikipedia:SCF_complex


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Path 1
Term Annotations click to browse term
  cellular_component 0
    intracellular 0
      ubiquitin ligase complex 0
        cullin-RING ubiquitin ligase complex 0
          SCF ubiquitin ligase complex 0
            SCF-Cdc4 ubiquitin ligase complex 0
            SCF-Ctf13 ubiquitin ligase complex 0
            SCF-Das1 ubiquitin ligase complex 0
            SCF-Dia2/Pof3 ubiquitin ligase complex 0
            SCF-Grr1/Pof2 ubiquitin ligase complex 0
            SCF-Hrt3/Pof7 ubiquitin ligase complex 0
            SCF-Mdm30 ubiquitin ligase complex 0
            SCF-Met30/Pof1 ubiquitin ligase complex 0
            SCF-Pof5 ubiquitin ligase complex 0
            SCF-Rcy1/Pof6 ubiquitin ligase complex 0
            SCF-Saf1/Pof9 ubiquitin ligase complex 0
            SCF-Skp2 ubiquitin ligase complex 0
            SCF-Ucc1 ubiquitin ligase complex 0
            SCF-Ufo1/Pof10 ubiquitin ligase complex 0
            SCF-YDR131C ubiquitin ligase complex 0
            SCF-YLR352W ubiquitin ligase complex 0
            cytoplasmic SCF ubiquitin ligase complex 0
            nuclear SCF ubiquitin ligase complex 0
Path 2
Term Annotations click to browse term
  cellular_component 0
    protein-containing complex 0
      catalytic complex 0
        transferase complex 0
          ubiquitin ligase complex 0
            cullin-RING ubiquitin ligase complex 0
              SCF ubiquitin ligase complex 0
                SCF-Cdc4 ubiquitin ligase complex 0
                SCF-Ctf13 ubiquitin ligase complex 0
                SCF-Das1 ubiquitin ligase complex 0
                SCF-Dia2/Pof3 ubiquitin ligase complex 0
                SCF-Grr1/Pof2 ubiquitin ligase complex 0
                SCF-Hrt3/Pof7 ubiquitin ligase complex 0
                SCF-Mdm30 ubiquitin ligase complex 0
                SCF-Met30/Pof1 ubiquitin ligase complex 0
                SCF-Pof5 ubiquitin ligase complex 0
                SCF-Rcy1/Pof6 ubiquitin ligase complex 0
                SCF-Saf1/Pof9 ubiquitin ligase complex 0
                SCF-Skp2 ubiquitin ligase complex 0
                SCF-Ucc1 ubiquitin ligase complex 0
                SCF-Ufo1/Pof10 ubiquitin ligase complex 0
                SCF-YDR131C ubiquitin ligase complex 0
                SCF-YLR352W ubiquitin ligase complex 0
                cytoplasmic SCF ubiquitin ligase complex 0
                nuclear SCF ubiquitin ligase complex 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.