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Term:SCF ubiquitin ligase complex
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Accession:GO:0019005 term browser browse the term
Definition:A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
Synonyms:exact_synonym: CDL1 complex;   CRL1 complex;   Cul1-RING ubiquitin ligase complex;   SCF complex;   Skp1/Cul1/F-box protein complex;   cullin-RING ligase 1
 narrow_synonym: SCF complex substrate recognition subunit
 xref: Wikipedia:SCF_complex


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SCF ubiquitin ligase complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07002848.1 RGD:13792537
G AABR07049223.1 RGD:13792537
G AC112018.1 RGD:13792537
G Amn1 antagonist of mitotic exit network 1 homolog JBrowse link 4 183,670,589 183,697,531 RGD:13792537
G Arih1 ariadne RBR E3 ubiquitin protein ligase 1 JBrowse link 8 64,166,359 64,268,555 RGD:1624291
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase JBrowse link 1 265,100,094 265,270,263 RGD:1624291
G Cacybp calcyclin binding protein JBrowse link 13 77,948,771 77,959,089 RGD:1624291
G Ccnf cyclin F JBrowse link 10 13,594,687 13,619,935 RGD:1624291
RGD:1600115
G Cks1b CDC28 protein kinase regulatory subunit 1B JBrowse link 2 188,740,564 188,745,144 RGD:13792537
G Cks1l CDC28 protein kinase regulatory subunit 1-like JBrowse link 5 110,831,843 110,832,242 RGD:13792537
G Cks2 CDC28 protein kinase regulatory subunit 2 JBrowse link 17 13,587,664 13,593,423 RGD:13792537
G Cul1 cullin 1 JBrowse link 4 77,211,814 77,283,369 RGD:1624291
RGD:13792537
G Cul2 cullin 2 JBrowse link 17 56,952,480 56,992,716 RGD:13792537
G Cul4a cullin 4A JBrowse link 16 81,718,784 81,756,653 RGD:13792537
G Cul4b cullin 4B JBrowse link X 124,831,391 124,870,329 RGD:13792537
G Cul5 cullin 5 JBrowse link 8 58,199,992 58,255,149 RGD:13792537
G Dmac2 distal membrane arm assembly complex 2 JBrowse link 1 82,413,171 82,419,157 RGD:13792537
G Fbh1 F-box DNA helicase 1 JBrowse link 17 70,399,093 70,437,151 RGD:1624291
G Fbxl12 F-box and leucine-rich repeat protein 12 JBrowse link 8 21,656,636 21,662,755 RGD:13792537
G Fbxl13 F-box and leucine-rich repeat protein 13 JBrowse link 4 10,020,349 10,170,012 RGD:13792537
G Fbxl15 F-box and leucine-rich repeat protein 15 JBrowse link 1 266,075,782 266,078,023 RGD:1624291
RGD:13792537
RGD:1600115
G Fbxl16 F-box and leucine-rich repeat protein 16 JBrowse link 10 15,176,489 15,188,729 RGD:13792537
G Fbxl17 F-box and leucine-rich repeat protein 17 JBrowse link 9 110,515,558 110,936,631 RGD:1624291
G Fbxl18 F-box and leucine-rich repeat protein 18 JBrowse link 12 13,728,155 13,751,781 RGD:13792537
G Fbxl19 F-box and leucine-rich repeat protein 19 JBrowse link 1 199,196,126 199,217,147 RGD:1624291
G Fbxl2 F-box and leucine-rich repeat protein 2 JBrowse link 8 122,240,393 122,290,439 RGD:1624291
RGD:13792537
G Fbxl20 F-box and leucine-rich repeat protein 20 JBrowse link 10 86,036,745 86,099,699 RGD:13792537
G Fbxl21 F-box and leucine-rich repeat protein 21 JBrowse link 17 8,505,771 8,520,208 RGD:1624291
RGD:13792537
G Fbxl22 F-box and leucine-rich repeat protein 22 JBrowse link 8 72,198,043 72,204,730 RGD:10400868
RGD:13792537
G Fbxl3 F-box and leucine-rich repeat protein 3 JBrowse link 15 93,647,307 93,667,395 RGD:1624291
RGD:13792537
G Fbxl4 F-box and leucine-rich repeat protein 4 JBrowse link 5 36,555,061 36,628,920 RGD:13792537
G Fbxl5 F-box and leucine-rich repeat protein 5 JBrowse link 14 71,852,649 71,891,143 RGD:1624291
RGD:13792537
G Fbxl6 F-box and leucine-rich repeat protein 6 JBrowse link 7 117,602,056 117,604,954 RGD:13792537
G Fbxl7 F-box and leucine-rich repeat protein 7 JBrowse link 2 79,067,907 79,439,987 RGD:1624291
RGD:13792537
G Fbxl8 F-box and leucine-rich repeat protein 8 JBrowse link 19 37,216,696 37,225,701 RGD:13792537
G Fbxo15 F-box protein 15 JBrowse link 18 81,785,408 81,882,796 RGD:1624291
G Fbxo17 F-box protein 17 JBrowse link 1 86,903,762 86,919,238 RGD:1624291
RGD:13792537
RGD:1600115
G Fbxo2 F-box protein 2 JBrowse link 5 164,972,483 164,977,912 RGD:1624291
RGD:13792537
G Fbxo25 F-box protein 25 JBrowse link 16 80,770,788 80,806,661 RGD:1624291
RGD:1600115
G Fbxo27 F-box protein 27 JBrowse link 1 86,872,808 86,878,709 RGD:1624291
G Fbxo31 F-box protein 31 JBrowse link 19 53,487,610 53,625,673 RGD:1600115
RGD:13792537
RGD:1624291
G Fbxo32 F-box protein 32 JBrowse link 7 98,065,664 98,098,071 RGD:1600115
RGD:1624291
G Fbxo33 F-box protein 33 JBrowse link 6 80,302,291 80,334,536 RGD:1600115
G Fbxo39 F-box protein 39 JBrowse link 10 58,874,028 58,878,445 RGD:13792537
G Fbxo4 F-box protein 4 JBrowse link 2 53,797,954 53,811,134 RGD:1624291
G Fbxo44 F-box protein 44 JBrowse link 5 164,962,921 164,972,273 RGD:1624291
RGD:13792537
G Fbxo45 F-box protein 45 JBrowse link 11 71,795,977 71,811,858 RGD:1624291
RGD:13792537
G Fbxo48 F-box protein 48 JBrowse link 14 100,129,835 100,140,400 RGD:13792537
G Fbxo6 F-box protein 6 JBrowse link 5 164,956,285 164,962,075 RGD:1624291
RGD:13792537
RGD:1600115
G Fbxo7 F-box protein 7 JBrowse link 7 23,815,246 23,843,505 RGD:1624291
G Fbxo9 f-box protein 9 JBrowse link 8 85,388,331 85,413,896 RGD:1624291
RGD:1600115
G Fbxw11 F-box and WD repeat domain containing 11 JBrowse link 10 17,542,374 17,640,718 RGD:1624291
G Fbxw4 F-box and WD repeat domain containing 4 JBrowse link 1 265,318,526 265,420,503 RGD:13792537
G Fbxw5 F-box and WD repeat domain containing 5 JBrowse link 3 2,726,705 2,731,213 RGD:1624291
RGD:1600115
G Fbxw7 F-box and WD repeat domain containing 7 JBrowse link 2 184,230,191 184,309,805 RGD:1624291
G Fbxw8 F-box and WD repeat domain containing 8 JBrowse link 12 44,046,204 44,138,138 RGD:1624291
G LOC100911548 SPRY domain-containing SOCS box protein 2-like JBrowse link 9 20,217,278 20,219,677 RGD:13792537
G Lrrc29 leucine rich repeat containing 29 JBrowse link 19 37,266,782 37,282,076 RGD:13792537
G Nccrp1 NCCRP1, F-box associated domain containing JBrowse link 1
1
85,558,420
85,213,578
85,559,652
85,218,030
RGD:13792537
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:1624291
G Rbx1 ring-box 1 JBrowse link 7 122,700,849 122,710,907 RGD:1624291
G Siah1 siah E3 ubiquitin protein ligase 1 JBrowse link 19 21,372,163 21,395,773 RGD:1624291
G Skp1 S-phase kinase-associated protein 1 JBrowse link 10 37,594,578 37,609,498 RGD:1600115
RGD:1624291
G Skp2 S-phase kinase associated protein 2 JBrowse link 2 58,506,146 58,534,211 RGD:1624291
RGD:13792537
G Spsb1 splA/ryanodine receptor domain and SOCS box containing 1 JBrowse link 5 166,913,734 166,978,534 RGD:13792537
G Spsb2 splA/ryanodine receptor domain and SOCS box containing 2 JBrowse link 4 157,325,980 157,328,380 RGD:13792537
G Spsb3 splA/ryanodine receptor domain and SOCS box containing 3 JBrowse link 10 14,248,199 14,253,815 RGD:13792537
G Spsb4 splA/ryanodine receptor domain and SOCS box containing 4 JBrowse link 8 104,840,939 104,912,959 RGD:13792537
G Trim21 tripartite motif-containing 21 JBrowse link 1 167,686,148 167,708,735 RGD:1624291
G Usp47 ubiquitin specific peptidase 47 JBrowse link 1 176,854,589 176,937,763 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20300
    intracellular 14243
      ubiquitin ligase complex 309
        cullin-RING ubiquitin ligase complex 171
          SCF ubiquitin ligase complex 70
            SCF-Cdc4 ubiquitin ligase complex 0
            SCF-Ctf13 ubiquitin ligase complex 0
            SCF-Das1 ubiquitin ligase complex 0
            SCF-Dia2/Pof3 ubiquitin ligase complex 0
            SCF-Grr1/Pof2 ubiquitin ligase complex 0
            SCF-Hrt3/Pof7 ubiquitin ligase complex 0
            SCF-Mdm30 ubiquitin ligase complex 0
            SCF-Met30/Pof1 ubiquitin ligase complex 0
            SCF-Pof5 ubiquitin ligase complex 0
            SCF-Rcy1/Pof6 ubiquitin ligase complex 0
            SCF-Saf1/Pof9 ubiquitin ligase complex 0
            SCF-Skp2 ubiquitin ligase complex 0
            SCF-Ucc1 ubiquitin ligase complex 0
            SCF-Ufo1/Pof10 ubiquitin ligase complex 0
            SCF-YDR131C ubiquitin ligase complex 0
            SCF-YLR352W ubiquitin ligase complex 0
            cytoplasmic SCF ubiquitin ligase complex 0
            nuclear SCF ubiquitin ligase complex 0
Path 2
Term Annotations click to browse term
  cellular_component 20300
    protein-containing complex 6095
      catalytic complex 1479
        transferase complex 823
          ubiquitin ligase complex 309
            cullin-RING ubiquitin ligase complex 171
              SCF ubiquitin ligase complex 70
                SCF-Cdc4 ubiquitin ligase complex 0
                SCF-Ctf13 ubiquitin ligase complex 0
                SCF-Das1 ubiquitin ligase complex 0
                SCF-Dia2/Pof3 ubiquitin ligase complex 0
                SCF-Grr1/Pof2 ubiquitin ligase complex 0
                SCF-Hrt3/Pof7 ubiquitin ligase complex 0
                SCF-Mdm30 ubiquitin ligase complex 0
                SCF-Met30/Pof1 ubiquitin ligase complex 0
                SCF-Pof5 ubiquitin ligase complex 0
                SCF-Rcy1/Pof6 ubiquitin ligase complex 0
                SCF-Saf1/Pof9 ubiquitin ligase complex 0
                SCF-Skp2 ubiquitin ligase complex 0
                SCF-Ucc1 ubiquitin ligase complex 0
                SCF-Ufo1/Pof10 ubiquitin ligase complex 0
                SCF-YDR131C ubiquitin ligase complex 0
                SCF-YLR352W ubiquitin ligase complex 0
                cytoplasmic SCF ubiquitin ligase complex 0
                nuclear SCF ubiquitin ligase complex 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.